Gut microbes play significant roles in colitis development. The current study was aimed to uncover the preventive effects of lycopene (LYC), a functional carotenoid component, on and accompanied behavior disorders. demonstrated that LYC treatment (50 mg/kg body weight/day) for 40 days prevented dextran sulfate sodium (DSS)-induced gut barrier damages inflammatory responses male mice. improved DSS-induced depression anxiety-like behavioral disorders by suppressing neuroinflammation synaptic...

Shenmai injection (SMI), as a patented traditional Chinese medicine, is extracted from Panax ginseng and Ophiopogon japonicus. It commonly used in the treatment of cardiovascular disease control cardiac toxicity induced by doxorubicin (DOX) treatment. However, its anti-cardiotoxicity mechanism remains unknown. The purpose this study was to investigate underlying mitochondrial protective mechanisms SMI on DOX-induced myocardial injury. cardioprotective effect against damage evaluated C57BL/6...

A new silver-catalyzed highly regio- and stereoselective difunctionalization reaction of simple terminal alkynes was reported in which the (Z)-beta-haloenol acetate derivatives were formed efficiently. The resulting products versatile intermediates organic synthesis.

S3•--mediated [1 + 2 2] and 3 1] cycloaddition reactions of aromatic alkynes to give tetraphenylthiophene 2-benzylidenetetrahydrothiophene derivatives via two C-S bond formations are developed. These protocols provide new, simple, straightforward strategies construct under transition-metal-free conditions. This study also expands the application S3•- in organic reactions.

Cascade cyclization reactions of S3˙-in situ generated from S2- with 1,3-enynes for the chemoselective synthesis 2,3,5-trisubstituted thiophenes and 3-thienyl disulfides controlled by sulfide salts are developed. These two protocols provide new, environment-friendly simple strategies to construct via formation six C-S bonds, respectively.

Introduction Pentatrichomonas hominis is a conditional pathogen that parasitizes the intestines of vertebrates and has been detected in various wild animals. However, its infection rate Tibetan antelopes not previously studied. Methods In this study, 503 fecal samples from were analyzed to determine prevalence molecular characteristics P. . Results showed 1.19% (6/503) tested positive, although was low, finding underscores importance monitoring animals population as hosts zoonotic pathogens....

Cryptosporidium is a significant zoonotic parasite with broad distribution in both humans and rodents. In this study, 510 fecal samples were collected from nine species of wild rodents across Guangxi, Yunnan, Hunan Provinces China. Nested PCR analysis targeting the SSU rRNA gene revealed an overall infection rate 1.8% (9/510) among these provinces. The highest positivity was observed Guangxi Province at 4.9% (5/103), followed by Yunnan (2.3%, 2/88), (0.6%, 2/319). Notably, Rattus losea...

Pentatrichomonas hominis is a zoonotic pathogen linked to gastrointestinal diseases in various animal species and humans. However, its prevalence of wild rodents remains unexplored. Therefore, investigating the molecular characteristics P. essential. M. Replace crossed out sentence above with following version:This study assessed by analyzing 510 fecal samples using nested PCR. Statistical analysis risk factors was performed SAS (v9.0) SPSS software. The infection rates were 18.18% (16/88)...

ABSTRACT Research has yielded conflicting quantitative conclusions regarding the relationship between plant diversity and carbon storage, leaving nature of this correlation at global scale unresolved. Here, study quantitatively evaluated strength ecological association through a synthetic analysis 285 diversity–carbon storage pair correlations from 115 studies published globally. Our findings demonstrate that although substantial heterogeneity exists among different categories, consistent...

Background: As a natural accelerator of highly pathogenic avian influenza in wild birds, the H9 subtype poses substantial threat to both humans and poultry industry. A comprehensive meta-analysis is necessary assess current status global outbreak. In this research, literature review are presented on surveillance studies birds worldwide up 2024. Methods: search strategy was employed, utilizing China Science Technology Journal Database, National Knowledge Infrastructure, PubMed, Google...

Government budget management serves as a critical enabler for the development of green economy and represents an essential pathway to promote sustainable urban development. The government delineates scope direction governmental activities, while advancement heavily relies on support budgetary funds. Adopting perspective capabilities, this study examines deviations across 288 prefecture-level cities in China from 2007 2021. By constructing double fixed-effects model, we assess whether can...

Aim: The aim of this study was to assess the efficacy snare traction technique in assisting endoscopic resection (ER) procedure gastric submucosal tumors (SMTs) ≥ 2 cm. Methods: Between January 2015 and December 2022, we retrospectively reviewed data from patients with SMTs cm who were treated by ER at first affiliated hospital Zhengzhou University. Then, propensity score matching (PSM) (1:3) between traction-assisted conventional procedures used overcome selection bias. success rate, en...

A chemoselective Co(<sc>ii</sc>)-catalyzed effective synthesis of sulfonylamidyl amide and 3-imine indole derivatives by using isocyanides sulfonyl azides has been developed.

University campuses are important components of cities, harboring the majority urban biodiversity. In this study, based on monthly bird survey data covering 12 university located either downtown or in newly developed areas Nanjing, China, 2019, we studied assembly processes each campus’s population and their main drivers by modeling a set ecological landscape determinants. Our results showed that (1) abundance species diversity were significantly higher than those downtown; (2) phylogeny...

Shenmai injection (SMI) has been used in the treatment of cardiovascular disease (CVD), such as heart failure, myocardial ischemia and coronary disease. It found to have efficacy on doxorubicin (DOX)-induced cardiomyopathy. The aims this study were explore underlying molecular mechanisms SMI CVD by using network pharmacology its protective effect DOX-induced cardiotoxicity vitro vivo experiment based prediction.Network method was reveal relationship between ingredient-target-disease...

Increasing evidence has indicated that opening of the mitochondrial permeability transition pore (mPTP) a vital role in myocardial ischemia/reperfusion (I/R) injury. Shenmai injection (SMI) plus Danshen (DSI) combination, termed Yiqi Yangyin Huoxue (YYH) therapy is used clinic to treat cardiovascular diseases, including I/R Previous studies by our group have demonstrated protective effect pretreatment with YYH against injury isolated rat hearts. The present study aimed examine...

Abstract: Chronic stable angina (CSA) is caused by coronary atherosclerosis. The gut microbiota (GM) and their metabolite trimethylamine-N-oxide (TMAO) levels are associated with Danlou tablet (DLT) combined Salvia miltiorrhiza ligustrazine (SML) injection has been used to treat CSA. This study aims investigate how DLT SML (DLT-SML) regulates serum lipids, inflammatory cytokines, GM community, microbial in patients In this study, 30 CSA were enrolled the DLT-SML group, 10 healthy volunteers...

Oxeiptosis is a recently discovered caspase-independent, non-inflammatory programmed cell death modality. Current studies suggest that oxeiptosis has crucial effects on biological processes in variety of diseases. However, the mechanism hepatocellular carcinoma (HCC) remains unclear and no relevant have been published. Therefore, this study intended to investigate prognostic role oxeiptosis-related genes HCC. We explored mechanisms molecular phenotypes underlying HCC through multi-omics...

Liver metastasis (LM) stands as a primary cause of mortality in metastatic colorectal cancer (mCRC), posing significant impediment to long-term survival benefits from targeted therapy and immunotherapy. However, there is currently lack comprehensive investigation into how senescent exhausted immune cells contribute LM.

Abstract Background Myasthenia gravis (MG) is an acquired autoimmune disease with high heterogeneity. The chronic, relapsing repeatedly and progressive acute exacerbation occasionally. Although the treatment of MG has developed, it still unsatisfactory some unexpected side effects. Traditional Chinese medicine (TCM) shown great potential in treatment, including relief muscle weakness syndrome, improvement patient’s quality life, reduction effects western medicine. purpose this study to...

This study aimed to determine the ideal pacing site in children by comparing postoperative ventricular synchrony with left bundle branch area and those right septal pacing.This retrospective included complete atrioventricular block who underwent permanent pacemaker implantation from March 2019 August 2021. Patients were grouped according their site, group group. Two-dimensional speckle tracking echocardiography was used evaluate synchrony.Forty-eight (median age, 2.7 years; interquartile...