A5100412838- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Traditional Chinese Medicine Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Lipoproteins and Cardiovascular Health
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ginseng Biological Effects and Applications
- Cardiovascular Health and Disease Prevention
- Medical Research and Treatments
- Thyroid Disorders and Treatments
- Pharmacological Effects of Natural Compounds
- Hormonal Regulation and Hypertension
- Neurogenesis and neuroplasticity mechanisms
- Inflammation biomarkers and pathways
- Flavonoids in Medical Research
- Barrier Structure and Function Studies
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Cardiovascular Function and Risk Factors
- Phytochemistry and Biological Activities
- Medicinal Plants and Bioactive Compounds
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
Tianjin University of Traditional Chinese Medicine
2011-2024
Capital Medical University
2008-2024
University of Macau
2024
Fujian University of Traditional Chinese Medicine
2024
Xuzhou Medical College
2022-2023
Cedars-Sinai Medical Center
2023
Affiliated Hospital of Nantong University
2023
Hunan University of Traditional Chinese Medicine
2023
Shanghai University
2023
Nantong University
2023
Type 2 diabetes mellitus (T2DM) is often accompanied by undiagnosed dyslipidemia. Research on the association of unconventional lipid markers with prediabetes (pre-DM) and T2DM simultaneously limited in coronary heart disease (CHD) patients.This study included 28,476 patients diagnosed CHD. Their levels, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C), were measured, non-traditional parameters calculated. The divided into three...
The modulation of microglial polarization from the pro-inflammatory M1 to anti-inflammatory M2 phenotype shows promise as a therapeutic strategy for ischemic stroke. Quercetin, natural flavonoid abundant in various plants, possesses anti-inflammatory, anti-apoptotic, and antioxidant properties. Nevertheless, its effect underlying mechanism on microglia/macrophages M1/M2 treatment cerebral ischemia/reperfusion injury (CI/RI) remain poorly explored. In current study, we observed that quercetin...
Baicalin (BA), a major polyphenol compound isolated from the extracts of Scutellaria radix, has been previously reported to ameliorate depressive-like behaviors in mice with chronic unpredictable mild stress (CUMS). However, its underlying antidepressant mechanisms remain unclear. This study was designed confirm antidepressant-like effects BA on CUMS induced behavioral abnormalities mice, and sought explore pharmacological vivo vitro. The procedure carried out induce depression mice....
Periodontitis is the sixth most prevalent diseases around globe, which closely related to many systemic and affects general health. As leading cause of tooth loss, periodontitis characterized by irreversible alveolar bone loss activated osteoclastogenic process, might be intracellular reactive oxygen species (ROS) in osteoclasts. Here, we demonstrated triggering receptor expressed on myeloid cells 2 (Trem2) as a key regulator osteoclastogenesis with regulation ROS signals periodontitis. In...
Shenmai injection (SMI), as a patented traditional Chinese medicine, is extracted from Panax ginseng and Ophiopogon japonicus. It commonly used in the treatment of cardiovascular disease control cardiac toxicity induced by doxorubicin (DOX) treatment. However, its anti-cardiotoxicity mechanism remains unknown. The purpose this study was to investigate underlying mitochondrial protective mechanisms SMI on DOX-induced myocardial injury. cardioprotective effect against damage evaluated C57BL/6...
Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of IIA, well-known Chinese medicine for treating cardiovascular disorders. Cardiomyocyte apoptosis plays major role in the development diseases. The present study was designed to investigate effects STS on cardiomyocyte induced by vivo acute myocardial infarction (MI) adult rats and vitro H2O2-treated neonatal rat ventricular myocytes. In MI rats, significantly reduced infarct sizes, blood lactate dehydrogenase (LDH) level,...
The intraventricular hemorrhage (IVH) secondary to intracerebral (ICH) was reported be relevant a higher incidence of hydrocephalus, which would result in poorer outcomes for patients with ICH. However, the mechanisms responsible this relationship remain poorly characterized. Thus, study designed further explore development and progression hydrocephalus after IVH.Autologous blood injection model induced mimic ICH ventricular extension (ICH/IVH) or primary IVH Sprague-Dawley rats. Magnetic...
Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) is one the new therapeutic strategies for treating ischemic stroke. However, relatively poor migratory capacity BMSCs toward infarcted regions limited potential this approach. Pharmacological preconditioning can increase expression CXC chemokine receptor 4 (CXCR4) in and enhance cell migration injury site. In present study, we investigated whether tetramethylpyrazine (TMP) could to brain improve functional recovery through...
Salvianolic acid B prevents body weight gain and improves insulin sensitivity in obese mice. The underlying mechanism behind these effects may be associated with the regulation of metabolic endotoxemia, gut microbiota homeostasis LPS/TLR4 pathway.
Background and aims: Xuanfei Baidu decoction (XFBD), a traditional Chinese medicine formulation, was designed successfully applied for COVID-19 disease treatment in China, while the mechanism is still not clear. Methods: To evaluate protective effect of XFBD on immunosuppression cyclophosphamide (CY)-treated mice, orally administrated, body weight measured, immune organ index calculated. HE staining performed to analyze pathological structures liver, spleen, thymus. The levels cytokines...
Since 1990, the incidence of stroke has been rising to become second leading cause death in world, posing a huge burden and challenge society families. Astragalus membranaceus Ligusticum chuanxiong (A&L) have used as traditional Chinese medicine (TCM) prescriptions treat prevent occurrence ischemic (IS), but their mechanism action on disease not fully elucidated. The main objective this study was reveal pharmacological A&L treatment IS perform preliminary validation. active...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes disease 2019 (COVID‐19), a illness that poses serious threat to global public health. In an essential step during infection, SARS‐CoV‐2 uses the receptor‐binding domain (RBD) of spike (S) protein engage with angiotensin‐converting enzyme (ACE2) in host cells. Chinese herbal medicines and their active components exhibit antiviral activity, luteolin being flavonoid can significantly inhibit SARS‐CoV infection....
Neuroinflammation and oxidative stress play a crucial role in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease. The triggering receptor expressed on myeloid cells 2 (TREM2), highly by microglia central nervous system (CNS), can modulate neuroinflammatory responses. Currently, there are no approved drugs specifically targeting TREM2 for CNS diseases. Aspidosperma alkaloids have shown potential as anti-inflammatory neuroprotective agents. This study aimed to...
Background & Aims: Somatic and germline CIDEB mutations are associated with protection from chronic liver diseases. The mechanistic basis whether suppression would be an effective therapy against fatty disease remain unclear. Methods: 21 somatic were introduced into cells to assess functionality. In vivo screening was used trace Cideb mutant clones in mice fed normal chow, western (WD), choline-deficient, L-amino acid-defined, high-fat (CDA-HFD) diets. Constitutive conditional knockout...
AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disease. Amyloid-β protein (Aβ), the hallmark of AD, invokes cascade mitochondrial dysfunction and eventually leads to neuronal death. l-3-n-Butylphthalide (l-NBP) has shown potent neuroprotective effects in stroke AD animal models. The present study evaluate effect l-NBP on Aβ25–35-induced injury possible mechanism human neuroblastoma SH-SY5Y cells. Our results showed that significantly attenuated cell death reduced...