A5073209052- Bone Metabolism and Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Antioxidants, Aging, Portulaca oleracea
- Bone health and osteoporosis research
- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Natural Antidiabetic Agents Studies
- Ginseng Biological Effects and Applications
- Hydrogen's biological and therapeutic effects
- Pharmacological Effects of Medicinal Plants
- Regulation of Appetite and Obesity
- Acupuncture Treatment Research Studies
- Pain Mechanisms and Treatments
- Advanced Glycation End Products research
- Gut microbiota and health
- Vitamin D Research Studies
- Biochemical effects in animals
- Phytochemistry and Biological Activities
- Sirtuins and Resveratrol in Medicine
- Fatty Acid Research and Health
- Ziziphus Jujuba Studies and Applications
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
Beijing University of Chinese Medicine
2019-2024
Peking University
2002
Salvianolic acid B prevents body weight gain and improves insulin sensitivity in obese mice. The underlying mechanism behind these effects may be associated with the regulation of metabolic endotoxemia, gut microbiota homeostasis LPS/TLR4 pathway.
This study was aimed at examining the effects of lycopene on bone metabolism in high-fat diet (HFD)- induced obese mice and to identify potential underlying mechanisms. Mice were fed a HFD for 12 weeks then continue with or without intervention (15 mg/kg) additional 10 weeks. The blood glucose lipid metabolism, as well serum levels total antioxidant capacity (T-AOC), superoxide dismutase (SOD), malondialdehyde (MDA) determined by biochemical assays. Bone histomorphological features...
Fructus Ligustri Lucidi (FLL) has been preclinically and clinically used to treat musculoskeletal diseases. However, whether how FLL affect the canonical Wnt/β‐catenin signaling in management of osteoporosis remains largely unknown. To this end, ovariectomized (OVX) rats primary osteoblasts were administrated with aqueous extract medicated serum, respectively. Supplement OVX maintains bone quality by attenuating reduction mineral density, strength microstructure. The maintenance may be...
Secreted by white adipose tissue as a hormone, resistin was identified possible link between obesity and insulin resistance. High circulating levels were observed to correlate with obesity. Administration of lowered the glucose tolerance threshold impaired activity; whereas anti-resistin antibodies had opposite effects. However, contradictory data subsequently reported in regard correlation expression level or type 2 diabetes. Two additional proteins that share highly homologous C-terminus...
Recent interest in preventing the development of osteoporosis has focused on regulation redox homeostasis. However, action lycopene (LYC), a strong natural antioxidant compound, osteoporotic bone loss remains largely unknown. Here, we show that oral administration LYC to OVX rats for 12 weeks reduced body weight gain, improved lipid metabolism, and preserved quality. In addition, treatment inhibited ROS overgeneration serum marrow rats, BMSCs upon H2O2 stimulation, leading inhibiting...
Recent interest in preventing the development of osteoporosis has focused on regulation redox homeostasis. However, action lycopene (LYC), a strong natural antioxidant com-pound, osteoporotic bone loss remains largely unknown. Here, we show that administra-tion LYC to OVX rats reduces body weight gain, improves lipid metabolism and preserves quality. In addition, treatment inhibits ROS overgeneration serum marrow rats, BMSCs upon H2O2 stimulation, leading inhibiting adipogenesis pro-moting...
Rehmanniae Radix Preparata (RRP) has been used to management of osteoporotic pain in traditional Chinese medicine trials. However, how RRP exhibits the anti-nociceptive effect remains largely unknown. To this end, estrogen-deficient rats were orally gavaged with aqueous extracts for 12 weeks. The tail flick latency, Von-Frey and formalin assays employed evaluate sensitization. administration alleviates allodynia hyperalgesia rats. These alterations associated a decrease expression substance...