A5100739601- Bone Metabolism and Diseases
- Sugarcane Cultivation and Processing
- MicroRNA in disease regulation
- Bone health and treatments
- Natural Products and Biological Research
- Circular RNAs in diseases
- Medicinal Plant Pharmacodynamics Research
- Cancer-related molecular mechanisms research
- Bone health and osteoporosis research
- Estrogen and related hormone effects
- TGF-β signaling in diseases
- Plant responses to water stress
- Neurological Disease Mechanisms and Treatments
- Trace Elements in Health
- Plant nutrient uptake and metabolism
- RNA Interference and Gene Delivery
- Biofuel production and bioconversion
- RNA Research and Splicing
- Extracellular vesicles in disease
- Neurogenesis and neuroplasticity mechanisms
- Natural product bioactivities and synthesis
- Heavy Metal Exposure and Toxicity
- Autophagy in Disease and Therapy
- Plant Gene Expression Analysis
- Alzheimer's disease research and treatments
Jinan University
2013-2025
Guangdong Provincial Hospital of Traditional Chinese Medicine
2022-2024
Guangxi Academy of Agricultural Science
2015-2023
Chinese Academy of Agricultural Sciences
2022-2023
Zhujiang Hospital
2022
Southern Medical University
2022
First Affiliated Hospital of Jinan University
2000-2021
Ministry of Agriculture and Rural Affairs
2020
Icariin (ICA), the main active flavonoid glucoside isolated from Herba Epimedii, has been shown to prevent postmenopausal bone loss in vitro. However, mechanisms by which ICA prevents vivo remain poorly understood. In present study, effect of an ovariectomized (OVX) rat model osteoporosis was evaluated. Sprague-Dawley rats were divided into sham‑operated and OVX groups. The randomly five groups: group (water only), Fosamax (positive) (5.04 mg/kg, weekly, administered orally), OVX‑ICA groups...
Alzheimer's disease (AD) is one of the most common types dementia that causes memory, thinking, and behavior problems. The important feature AD gradual irreversible loss cognitive ability through formation amyloid β (Aβ) plaques neurofibrillary tangles composed tau protein. metabolism Aβ proteins closely related to affected by autophagy. Current research speculates autophagy dysfunction leads an increase in harmful AD. β-Asarone main constituent Acorus tatarinowii Schott has effects on...
Brain-derived neurotrophic factor (BDNF)-tropomyosin-related kinase B (TrkB) plays a critical role in the pathogenesis of depression by modulating synaptic structural remodeling and functional transmission. Previously, we have demonstrated that ginsenoside Rb1 (Rb1) presents novel antidepressant-like effect via BDNF-TrkB signaling hippocampus chronic unpredictable mild stress (CUMS)-exposed mice. However, underlying mechanism through which counteracts stress-induced aberrant hippocampal...
The aim of the present study was to investigate effects quercetin on mitogen-activated protein kinase (MAPK) signaling pathway in osteogenic differentiation rat mesenchymal stem cells (MSCs). A 3-(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide assay and an alkaline phosphatase (ALP) were used determine (concentrations 0.1, 1 10 µmol/l) proliferation MSCs expression ALP, respectively. In addition, through introduction inhibitors p38 MAPK, extracellular signal‑regulated (ERK)1/2...
Sugarcane is an important sugar and energy crop that widely planted in the world. Among environmental stresses, water-deficit stress most limiting to plant productivity. Some groups have used PCR-based microarray technologies investigate gene expression changes of multiple sugarcane cultivars under water stress. Our knowledge about genes response deficit still poor. A wild type, Saccharum narenga, was selected treated with drought for 22 days. Leaves from (DTS) control (CK) plants were...
Abstract MicroRNAs (miRNAs) regulate activities in living organisms through various signaling pathways and play important roles the development progression of osteoporosis. The balance between osteogenic adipogenic differentiation rBMSCs is closely related to occurrence ERα regulates bone metabolism tissues. However, correlation among ERα, miRNAs, still unclear. In this study, we used lentivirus transfection into construct an ERα‐deficient model, analyzed differences expressed miRNAs control...
Resveratrol (RES) is a natural polyphenolic compound with broad range of physiological and pharmacological properties. Previous studies have shown that RES also plays an important role in protecting promoting early bone metabolism differentiation. The accumulation cadmium (Cd), one the world's most poisonous substances, can inhibit skeletal growth maturation, thus causing osteoporosis. However, whether prevent Cd-induced inhibition osteogenic differentiation remains unknown. In this study,...
Cadmium is an environmental metal pollutant that has been a focus of research in recent years, which reported to cause bone disease; however, its skeletal toxicity and the mechanism involved are not yet fully known. Therefore, this study used MC3T3-E1 subclone 14 cells determine cadmium on bone. chloride (Cd) significantly reduced cell viability concentration-dependent manner. Exposure Cd inhibited osteoblast-related proteins (Runx2, Col-1, STC2) decreased alkaline phosphatase (ALP)...
Type 2C protein phosphatases (PP2Cs) represent a major group of in plants, some which have already been confirmed to play important roles diverse plant processes. In this study, analyses the phylogenetics, gene structure, domain, chromosome localization, and collinearity, as well an identification expression profile, protein-protein interaction, subcellular location, were carried out on PP2C family wild sugarcane (Saccharum spontaneum). The results showed that 145 proteins classified into 13...
Puerarin is an isoflavone extracted from Radix Puerariae, a traditional Chinese herb used to treat many diseases such as osteoporosis. In this study, puerarin was shown stimulate alkaline phosphatase (ALP) activity, type I collagen (Col I) secretion, and mineralized nodules formation of primary osteoblasts. Whereas the estrogen receptor (ER) antagonist ICI 182780 able reduce increase in ALP activity Col secretion induced by puerarin. Furthermore, elevate levels phospho-p38 mitogen-activated...
Internode elongation is one of the most important traits in sugarcane because its relation to crop productivity. Understanding microRNA (miRNA) and mRNA expression profiles related internode would help develop molecular improvement strategies but they are not yet well-investigated. To identify genes miRNAs involved elongation, cDNA small RNA libraries from pre-elongation stage (EI), early (EII) rapid (EIII) were sequenced their studied.Based on sequencing results, 499,495,518 reads 80,745...
Osteoporosis (OP) is a disease affecting the elderly and characterized by incremental fractures bone fragility. Small extracellular vesicles (sEVs) derived from mesenchymal stem cells have been demonstrated to possess potent regeneration potential. In this study, we evaluated osteogenesis effects of sEVs Epimedium-preconditioned (EPI-sEV) osteoblasts ovariectomized (OVX) rats. The underlying mechanism EPI-sEV-induced was explored RNA-sequencing verified transfection with corresponding mimic...
Fructus Ligustri Lucidi (FLL) has been preclinically and clinically used to treat musculoskeletal diseases. However, whether how FLL affect the canonical Wnt/β‐catenin signaling in management of osteoporosis remains largely unknown. To this end, ovariectomized (OVX) rats primary osteoblasts were administrated with aqueous extract medicated serum, respectively. Supplement OVX maintains bone quality by attenuating reduction mineral density, strength microstructure. The maintenance may be...
Sugarcane (Saccharum spp.) is an important cash crop, and drought factors limiting its yield. To study the resistance mechanism of sugarcane, transcriptomes two sugarcane varieties with different levels were compared under water shortage levels. The results showed that significantly different. differentially expressed genes enriched in starch sucrose metabolism, linoleic acid glycolysis/gluconeogenesis, glyoxylate dicarboxylate metabolic pathways. Unique trend variety strong (F172)...
Abstract Background: β-Asarone is the main constituent of Acorus tatarinowii Schott and exhibits important effects in diseases such as neurodegenerative neurovascular diseases. Icariin (ICA) a major active ingredient Epimedium that has attracted increasing attention because its unique pharmacological degenerative disease. In this paper, we primarily explored combination β-asarone ICA clearing noxious proteins reversing cognitive deficits. The accumulation damaged mitochondria mitophagy are...
Triple-negative breast cancer (TNBC) lacks a recognized therapeutic molecular target and has an unfavorable prognosis. (20S)-Protopanaxatriol (g-PPT, PPT) is active metabolite extracted from ginseng. Accumulating evidence suggests that it good anti-cancer activity in vivo vitro. In this study, we aimed to elucidate the anti-tumor effects of PPT TNBC cells tumor-bearing mice, as well relevant mechanisms autophagy apoptosis. vitro, have found capable inducing non-protective apoptosis, thus...