A5100408500- Gene expression and cancer classification
- Catalytic C–H Functionalization Methods
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Probiotics and Fermented Foods
- Plant biochemistry and biosynthesis
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Catalytic Cross-Coupling Reactions
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Electrochemical Analysis and Applications
- Sulfur-Based Synthesis Techniques
- Bone Metabolism and Diseases
- Receptor Mechanisms and Signaling
- Pharmacogenetics and Drug Metabolism
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Asymmetric Hydrogenation and Catalysis
- MicroRNA in disease regulation
- Genetic Associations and Epidemiology
- Ginseng Biological Effects and Applications
- Synthesis and biological activity
- Alzheimer's disease research and treatments
Huanghuai University
2021-2024
Jinan University
2017-2024
Heilongjiang University of Chinese Medicine
2023-2024
Kunming University of Science and Technology
2024
Shanghai University of Traditional Chinese Medicine
2024
First Affiliated Hospital of Jinan University
2013-2024
Huazhong Agricultural University
2023
WuXi AppTec (China)
2022-2023
State Key Laboratory of Applied Organic Chemistry
2016-2022
Lanzhou University
2016-2022
Rhodium-catalyzed C7-selective decarbonylative arylation, olefination, and methylation of indoles with carboxylic acids or anhydrides by C-H C-C bond activation have been developed. Furthermore, C7-acylation products can also be generated selectively at a lower reaction temperature in the developed system. The key to high reactivity regioselectivity this transformation is appropriate choice an indole N-PtBu2 chelation-assisted group. This method has many advantages, including easy access...
Although Alzheimer's disease (AD) is a central nervous system and type 2 diabetes MELLITUS (T2DM) metabolic disorder, an increasing number of genetic epidemiological studies show clear link between AD T2DM. The current approach to uncovering the shared pathways T2DM involves association analysis; however such analyses lack power discover mechanisms diseases. As alternative, we developed novel causal inference methods for pipelines systematic multi-omic casual analysis infer multilevel omics...
Large-scale metabolomics is a powerful technique that has attracted widespread attention in biomedical studies focused on identifying biomarkers and interpreting the mechanisms of complex diseases. Despite rapid increase number large-scale metabolomic studies, analysis data remains key challenge. Specifically, diverse unwanted variations batch effects processing many samples have substantial impact true biological markers, it daunting challenge to annotate plethora peaks as metabolites...
An efficient and concise approach for the synthesis of polysubstituted pyridines has been achieved through copper-catalyzed oxidative sp3 C–H coupling oxime acetates with toluene derivatives. Besides, benzylamine p-toluenesulfonylhydrazone were also introduced to react enrich diversity this synthetic method. These transformations provide highly flexible facile preparation substituted thus are useful in practical synthesis.
Although recent decades have witnessed the synthesis of 1,3,4-thiadiazoles via phosphorus POCl3-promoted cyclization reaction, simultaneous access to 2-amino-1,3,4-thiadiazole and 2-amino-1,3,4-oxadiazole analogs remains unexpected elusive. Herein, a detailed regiocontrolled 2-amino-1,3,4-thiadiazoles in good high yields with regioselectivities from readily available thiosemicarbazides using POCl3 was disclosed. Meantime, establish comprehensive structure–activity relationship, derivatives...
The first example of intramolecular ring-opening and reconstruction cyclobutanone oxime esters <italic>via</italic> selective C–C bond cleavage leading to the synthesis 3,4-dihydronaphthalene-2-carbonitriles in presence a cheap copper catalyst has been reported.
A practical and mild method for the switchable synthesis of sulfoxides or sulfones via selective oxidation sulfides using cheap N-fluorobenzenesulfonimide (NFSI) as oxidant has been developed. These highly chemoselective transformations were simply achieved by varying NFSI loading with H2O green solvent oxygen source without any additives. The good functional group tolerance makes strategy valuable.
Depression severely impairs the health of people all over world. Cognitive dysfunction due to depression has resulted in a severe economic burden family and society induced by reduction social functioning patients. Norepinephrine-dopamine reuptake inhibitors (NDRIs) targeted with human norepinephrine transporter (hNET) distributed dopamine (hDAT) simultaneously treat improve cognitive function, they effectively prevent sexual other side effects. Because many patients continue poorly respond...
Abstract Rhodium‐catalyzed C7‐selective decarbonylative arylation, olefination, and methylation of indoles with carboxylic acids or anhydrides by C−H C−C bond activation have been developed. Furthermore, C7‐acylation products can also be generated selectively at a lower reaction temperature in the developed system. The key to high reactivity regioselectivity this transformation is appropriate choice an indole N ‐P t Bu 2 chelation‐assisted group. This method has many advantages, including...
During plant growth and development, the YABBY gene plays a crucial role in morphological structure, hormone signaling, stress resistance, crop breeding, agricultural production of lateral organs, leaves, flowers, fruits. Astragalus mongholicus is perennial herbaceous legume family, widely used worldwide due to its high medicinal edible value. However, there have been no reports family A. mongholicus. This study bioinformatics methods, combined with databases analysis websites,...
The Basic Leucine Zipper (bZIP) transcription factors (TFs) family is among of the largest and most diverse gene families found in plant species, members bZIP TFs perform important functions developmental processes stress response. To date, genes Platycodon grandiflorus have not been characterized. In this work, a number 47 PgbZIP were identified from genome P. , divided into 11 subfamilies. distribution these on chromosome replication events analyzed. motif, structure, cis -elements,...
Trollius chinensis Bunge (TCB) is a perennial plant of the Ranunculaceae family with medicinal and edible values. It widely distributed commonly used in various regions, including Asia, Europe, North America. The main chemical components TCB include alkaloids, flavonoids, phenolic acids, volatile oil compounds. renowned for its anti-inflammatory, heat-clearing, detoxifying, eyesight-improving properties. Its dried flowers are as traditional Chinese medicine indicated treatment upper...
A series of "drug-like" compounds based on quinoxaline scaffold with arylsulfonyl hydrazinyl, arylformyl hydrazinyl or groups at C-2 and aryloxy C-3, were synthesized in 4 5 steps involving cyclization, chlorination coupling reactions. Cellular anti-proliferative activities these derivatives vitro determined, which revealed that the inhibitory potency selectivity 6f was comparable to positive control.
Abstract Due to its promising capacity in improving drug efficacy, polypharmacology has emerged be a new theme the discovery of complex disease. In process novel multi-target drugs (MTDs) discovery, silico strategies come quite essential for advantage high throughput and low cost. However, current researchers mostly aim at typical closely related target pairs. Because intricate pathogenesis networks diseases, many distantly targets are found play crucial role synergistic treatment....