A5087867198- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Asymmetric Hydrogenation and Catalysis
- Crystallization and Solubility Studies
- Organoboron and organosilicon chemistry
- X-ray Diffraction in Crystallography
- Fluorine in Organic Chemistry
- Nematode management and characterization studies
- Cyclopropane Reaction Mechanisms
- Chemical Reactions and Isotopes
- Insect Pheromone Research and Control
- Crystallography and molecular interactions
- Insect-Plant Interactions and Control
- Chemical Synthesis and Reactions
- Forest Insect Ecology and Management
- Entomopathogenic Microorganisms in Pest Control
- Microbial Metabolism and Applications
- Plant Parasitism and Resistance
- Plant Pathogenic Bacteria Studies
- Asymmetric Synthesis and Catalysis
- Lanthanide and Transition Metal Complexes
- Enzyme Structure and Function
Nanjing University
2016-2025
Nanjing Forestry University
2005-2025
Beijing Tsinghua Chang Gung Hospital
2025
Tsinghua University
2025
Nanjing University of Chinese Medicine
2020
Yangzhou University
2014-2016
Canadian Forest Service
2000
Abstract The first example of intermolecular olefination cyclobutanone oximes with alkenes via selective C−C bond cleavage leading to the synthesis nitriles in presence a cheap copper catalyst is reported. procedure distinguished by mild and safe reaction conditions that avoid ligand, oxidant, base, or toxic cyanide salt. A wide scope cyclobutanones olefin coupling components can be used without compromising efficiency scalability. alternative visible‐light‐driven photoredox process for this...
A series of in situ formed alkenyl diboronate complexes from Grignard reagents (commercially available or prepared bromides and Mg) with B2 Pin2 (bis(pinacolato)diboron) react diverse alkyl halides by a Ru photocatalyst to give various gem-bis(boryl)alkanes. Alkyl radicals add efficiently the complexes, adduct radical anions undergo radical-polar crossover, specifically, 1,2-boryl-anion shift boron α-carbon sp2 center. This transformation shows good functional-group compatibility can serve...
Abstract Transition metal-catalysed C–H hydroxylation is one of the most notable advances in synthetic chemistry during past few decades and it has been widely employed preparation alcohols phenols. The site-selective aromatic bonds under mild conditions, especially context substituted (hetero)arenes with diverse functional groups, remains a challenge. Here, we report general chelation-assisted mediated by boron species without use any transition metals. Diverse bearing amide directing...
The efficient palladium-catalyzed synthesis of esters from readily available arenes has been developed. These C–H bond esterifications were achieved relying on the regioselective thianthrenation to generate aryl-TT salts, which treated as reactive electrophilic substrates couple with phenol formate and N-hydroxysuccinimide (NHS) giving access NHS esters, respectively, in absence carbon monoxide. A wide range functional could be prepared high efficiency under this redox-neutral...
A novel rearrangement of cycloketoxime esters to cyano-containing benzoates beyond the traditional Beckmann and Neber process has been established in presence photocatalysis catalysis.
Abstract A novel structural reorganization of cycloketoxime esters beyond the traditional Beckmann rearrangement process has been established to build cyano‐containing ketones in presence photocatalyst. This transformation is remarkable with selective C—C bond cleavage and an oxidation enabled by DMSO used as solvent, oxidant, oxygen source avoiding acid, base toxic cyanide salts cyano source. Further applications late‐stage modification complex chiral molecules have also reported.
Abstract Three bacterial strains Njh, Njt and Njw, have been isolated with a high frequency from the xylem of wilted black pine ( Pinus thuntergii ) surface wood nematodes Bursaphelenchus xylophilus ). These bacteria identified as Pseudomonas fluorescens biotype I, P. II species genus Pantoea respectively. To determine pathogenicity, callus aseptic seedlings were inoculated follows: only (each B. mucronatus ); bacterium strain Njt, Njw) plus in combination each Njw). The results showed that...
A novel transformation for the construction of Csp<sup>3</sup>–Csp bonds was achieved <italic>via</italic> a photo-induced copper-catalysed C–C bond cleavage.
The first example of intramolecular ring-opening and reconstruction cyclobutanone oxime esters <italic>via</italic> selective C–C bond cleavage leading to the synthesis 3,4-dihydronaphthalene-2-carbonitriles in presence a cheap copper catalyst has been reported.
A practical single-electron-transfer-induced selective C(sp3)–N coupling of cycloketoximes with anilines via C–C bond cleavage under copper-catalytic and synergetic photoredox/copper-catalytic reaction systems has been uncovered. These two powerful simple protocols demonstrated excellent selectivity good functional group compatibility without any base or ligand control. Preliminary mechanistic experiments indicated that a radical-mediated process was involved in these transformations.
A palladium-catalyzed deuterated formylation of aryl sulfonium salts is prepared conveniently from readily available arenes, which enables the expedient synthesis a series structurally diverse C-1 aldehydes with 96%-99% deuterium incorporation. The easy to handle and cost-effective DCOONa provides source, can be introduced onto formyl units excellent selectivity under palladium-catalytic redox neutral conditions. This catalytic route accomplish direct late-stage C-H functionalization...
In the past decade, transition-metal-catalyzed C-H activations have been very popular in research field of organometallic chemistry, and considered as efficient convenient strategies to afford complex natural products, functional advanced materials, fluorescent compounds, pharmaceutical compounds. this account, we begin with a brief introduction development activation, especially chelation-assisted activation. Then, more detailed discussion is directed towards our recent studies on oxidative...
Summary Interactions between the pine wood nematode (PWN), Bursaphelenchus xylophilus , and bacteria of genus Pseudomonas were examined by cultivating axenic PWN bacterial strains using callus Pinus thunbergii . Ten ( fluorescens putida cepacia spp.) 29 tested, significantly increased reproduction PWN. The rest (19 10 species) inhibited completely. growth 18 including promoting reproduction, was presence It indicated a mutualistic symbiotic relationship in Pseudomonas. symbionts are...
Abstract The first example of intermolecular olefination cyclobutanone oximes with alkenes via selective C−C bond cleavage leading to the synthesis nitriles in presence a cheap copper catalyst is reported. procedure distinguished by mild and safe reaction conditions that avoid ligand, oxidant, base, or toxic cyanide salt. A wide scope cyclobutanones olefin coupling components can be used without compromising efficiency scalability. alternative visible‐light‐driven photoredox process for this...
Abstract We describe an efficient catalyst‐ and metal‐free aminoboration of alkynes to 3‐borylated indoles using one the least expensive boron sources, BCl 3 . The major dichloro(indolyl)borane products can be used for in situ construction useful 3‐Bpin indoles. This simple mild method provides a novel approach synthesis various with high regioselectivity wide substrate scope. magnified image
A photoredox catalytic deoxygenative platform utilizing readily available alcohols was established, providing an operationally simple and practical route to divergent functionalizations assisted by N,O-heterocyclic carbenes.
The Nozaki-Hiyama-Kishi reaction offers effective and reliable strategies for the preparation of alcohols via carbon-carbon bond formation. Typical methods usually require stoichiometric amounts chromium salts, co-transition metals, auxiliary reagents, which limits their practical application in industrial chemistry. To mitigate these limitations, substantial efforts have been made to develop chromium-catalytic approaches. However, an excess metal reductants or expensive photocatalysts...
Abstract A series of in situ formed alkenyl diboronate complexes from Grignard reagents (commercially available or prepared bromides and Mg) with B 2 Pin (bis(pinacolato)diboron) react diverse alkyl halides by a Ru photocatalyst to give various gem‐bis(boryl)alkanes. Alkyl radicals add efficiently the complexes, adduct radical anions undergo radical‐polar crossover, specifically, 1,2‐boryl‐anion shift boron α‐carbon sp center. This transformation shows good functional‐group compatibility can...
A copper-catalysed three-component reaction utilizing readily available feedstocks was investigated, providing an operationally simple and practical route to trifluoromethyl allenes under mild environmentally friendly conditions.
Abstract A synthesis of pyrido[2,1‐ a ]isoindoles is reported by the rhodium‐catalyzed direct oxidative CH acylation 2‐aryl pyridines with terminal alkynes. The desired products were obtained in moderate to excellent yields. This an efficient and clean method construct CC/CN bonds one step. In addition, effective rhodium(III) catalyst was isolated characterized X‐ray crystallography. magnified image
A heterogeneous redox-neutral palladium-catalytic platform was reported for the preparation of deuterated (hetero) arenes from mediated by regioselective C(sp2)-H thianthrenation utilizing commercially available and recyclable Pd/C catalyst. wide range compounds could be obtained in high yields with excellent levels deuterium incorporation under these simple catalytic conditions requirement stable easily handled DCOONa as a source. The late-stage deuteration pharmaceuticals bioactive...