A5100444865- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Radical Photochemical Reactions
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Sulfur-Based Synthesis Techniques
- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Cyclopropane Reaction Mechanisms
- Synthesis and Biological Evaluation
- Synthesis of Indole Derivatives
- Salmonella and Campylobacter epidemiology
- Molecular Sensors and Ion Detection
- Synthetic Organic Chemistry Methods
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Fluorine in Organic Chemistry
- Organoboron and organosilicon chemistry
- Luminescence and Fluorescent Materials
- Enzyme Catalysis and Immobilization
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Sulfur Compounds in Biology
Yangzhou University
2016-2025
Sichuan University
2017-2024
Chinese Academy of Fishery Sciences
2023
Ministry of Agriculture and Rural Affairs
2023
Dongguan People’s Hospital
2023
Guangdong Medical College
2023
Liaoning Shihua University
2022
Tongji University
2021
Shaanxi University of Science and Technology
2021
Louisiana State University
2021
A copper catalytic system was established for the stereoselective hydrodefluorination of gem-difluoroalkenes through C-F activation to synthesize various Z fluoroalkenes. H2 O is used as hydrogen source fluorine acceptor moiety. This mild shows good-functional group compatibility, accepting a range carbonyls precursors gem-difluoroalkenes, including aliphatic, aromatic, and α,β-unsaturated aldehydes even ketones. It serves powerful synthetic method late-stage modification complex compounds.
Abstract Potassium hydroxide (KOH) in dimethyl sulfoxide (DMSO) forms a superbasic medium that allows one to access cross‐coupling products from reactions between aryl halides with various sulfur‐, oxygen‐ and nitrogen‐based nucleophiles under transition metal‐free conditions.
Rhodium-catalyzed C7-selective decarbonylative arylation, olefination, and methylation of indoles with carboxylic acids or anhydrides by C-H C-C bond activation have been developed. Furthermore, C7-acylation products can also be generated selectively at a lower reaction temperature in the developed system. The key to high reactivity regioselectivity this transformation is appropriate choice an indole N-PtBu2 chelation-assisted group. This method has many advantages, including easy access...
By developing a new Ir(III)-catalyzed C-C cross-coupling, versatile method for direct arylation of sp(2) and sp(3) C-H bonds in ketoximes, nitrogen-containing heterocycles, various arenes, olefins has been established. The key to this depends on the appropriate choice catalyst use diaryliodonium triflate salts as coupling partners. This transformation good functional group compatibility can serve powerful synthetic tool late-stage complex compounds. Mechanistic studies by density theory...
A series of in situ formed alkenyl diboronate complexes from Grignard reagents (commercially available or prepared bromides and Mg) with B2 Pin2 (bis(pinacolato)diboron) react diverse alkyl halides by a Ru photocatalyst to give various gem-bis(boryl)alkanes. Alkyl radicals add efficiently the complexes, adduct radical anions undergo radical-polar crossover, specifically, 1,2-boryl-anion shift boron α-carbon sp2 center. This transformation shows good functional-group compatibility can serve...
Abstract Transition metal-catalysed C–H hydroxylation is one of the most notable advances in synthetic chemistry during past few decades and it has been widely employed preparation alcohols phenols. The site-selective aromatic bonds under mild conditions, especially context substituted (hetero)arenes with diverse functional groups, remains a challenge. Here, we report general chelation-assisted mediated by boron species without use any transition metals. Diverse bearing amide directing...
Abstract An efficient and clean method to construct CC bonds has been developed via the acylation reaction of acetanilides with benzylic alcohols using tert ‐butyl hydroperoxide (TBHP) as oxidant catalyzed by palladium acetate in presence triflic acid (TfOH). The reactions exhibit excellent reactivities, up 95% yield corresponding aryl ketone could be obtained under optimal conditions.
[reaction: see text] A highly efficient aza Diels-Alder reaction of Danishefsky's diene with imines was found to occur in methanol the absence any acids at room temperature give corresponding 2-substituted dihydro-4-pyridone derivatives high yields. This can be also carried out a three-component one-pot manner. The proceed through Mannich-type condensation mechanism.
Kendomycin, also known as (-)-TAN 2162, is a novel polyketide-derived ansamycin isolated from Streptomyces sp., which exhibits potent antagonist and agonist activities at the endothelin calcitonin receptors, respectively. This bacterial metabolite possesses strong antibiotic activity against range of gram-positive -negative bacteria cytostatic effects on growth human cancer cell lines. When macroglycosidation reaction employed key step, first enantioselective total synthesis kendomycin has...
A novel rearrangement of cycloketoxime esters to cyano-containing benzoates beyond the traditional Beckmann and Neber process has been established in presence photocatalysis catalysis.
An intramolecular enantioselective C–H arylation of ferrocenyl aryl sulfides was performed with a palladium catalyst. Planar chiral thiophene compounds ferrocene skeleton were constructed in good enantioselectivities (up to 99% ee) and high yields, the utility obtained as ligands catalytic reactions has been demonstrated.
Directed by the strategy of C–H activation relay (CHAR), an efficient construction isatin skeleton was developed through catalytic oxidation glycine esters. The mechanistic study reveals that relatively active bonds initiated followed remote and inert bonds, intramolecular 1,6-hydrogen shift involved as a key step.
Ruthenium (Ru) single atoms were decorated on the surface of graphitic carbon nitride (g-C3N4) successfully in this work. By varieties characterization, existence Ru and defects (cyano groups) caused process synthesis have been confirmed. The catalyst by (Ru-CCN-0.05) had better absorption capacity a wider range light than with no loading (Ru-CCN-0). Without help hole-scavengers, rate photocatalytic nitrogen fixation Ru-CCN-0.05 ultra-pure water was 2.26 mg L−1 gcat −1 h−1, 1.5 times that...
Simply mixing the neat substrates and a small amount of chiral catalyst (0.1–0.01 mol %) under nearly solvent-free conditions makes enantioselective carbonyl-ene reaction glyoxylate ester with variety olefins proceed smoothly to afford corresponding α-hydroxy esters in high yields excellent enantioselectivities [Eq. (1)].
Abstract A copper catalytic system was established for the stereoselective hydrodefluorination of gem‐difluoroalkenes through C−F activation to synthesize various Z fluoroalkenes. H 2 O is used as hydrogen source fluorine acceptor moiety. This mild shows good‐functional group compatibility, accepting a range carbonyls precursors gem‐difluoroalkenes, including aliphatic, aromatic, and α,β‐unsaturated aldehydes even ketones. It serves powerful synthetic method late‐stage modification complex compounds.
A highly selective sp<sup>3</sup>C–N cleavage of tertiary anilines was achieved using the TBN/TEMPO catalyst system.
A tunable functionalization of saturated C–C and C–H bonds N,N′-diarylpiperazine derivatives was realized by tert-butyl nitrite (TBN) NaNO2 systems, respectively. When TBN employed as the oxidant, bond cleavage occurred smoothly, providing a series formamides in good yields. In presence NaNO2, oxidation achieved, resulting efficient synthesis nitroalkenes. The mechanistic study shows that mixed mechanism is involved these reactions, which generated enamine might be key intermediate.
A novel transformation for the construction of Csp<sup>3</sup>–Csp bonds was achieved <italic>via</italic> a photo-induced copper-catalysed C–C bond cleavage.
The first example of intramolecular ring-opening and reconstruction cyclobutanone oxime esters <italic>via</italic> selective C–C bond cleavage leading to the synthesis 3,4-dihydronaphthalene-2-carbonitriles in presence a cheap copper catalyst has been reported.
A tris(4-bromophenyl)aminium hexachloroantimonate-initiated oxidative Povarov-type reaction between glycines and methylenecyclopropanes was realized in the presence of dioxygen, which counterion, SbCl6–, served as a chlorine atom donor, enabling synthesis series chlorinated quinolines high yields. The mechanistic study showed that chlorination step might be related to antimony chloride via radical transfer.