A5063866148- Ultrasound and Hyperthermia Applications
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Cervical Cancer and HPV Research
- Congenital Heart Disease Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Structural Load-Bearing Analysis
- Microfluidic and Capillary Electrophoresis Applications
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Genital Health and Disease
- Minerals Flotation and Separation Techniques
- Pregnancy and preeclampsia studies
- Ultrasound in Clinical Applications
- Parasites and Host Interactions
- Reproductive tract infections research
- Anatomy and Medical Technology
- Ultrasound and Cavitation Phenomena
- Structural Engineering and Vibration Analysis
- Safety and Risk Management
- MRI in cancer diagnosis
Southwest Hospital
2016-2025
Army Medical University
2016-2025
Tongji University
2024-2025
Shimadzu (China)
2022-2025
Nanchang Institute of Technology
2013-2024
Changzhi Medical College
2024
Shihezi University
2021-2024
Yuncheng University
2023-2024
Shanxi University
2024
Heilongjiang University of Chinese Medicine
2021-2024
Background Recent studies have demonstrated that transplantation of adipose-derived stem cell (ADSC) can improve cardiac function in animal models myocardial infarction (MI). However, the mechanisms underlying beneficial effect are not fully understood. In this study, we characterized paracrine transplanted ADSC and investigated its relative importance versus direct differentiation mediated repair. Methodology/Principal Findings MI was experimentally induced mice by ligation left anterior...
The purpose of this study was to investigate the safety sulfur hexafluoride microbubble contrast agent SonoVue (Bracco SpA, Milan, Italy) and implement precautions with intent further improving agent.A total 30,222 patients undergoing contrast-enhanced sonography abdominal superficial organs in our hospital from January 2005 December 2014 were retrospectively investigated. used as ultrasound agent. symptoms treatments adverse reactions occurring during sonographic examinations reviewed...
The elderly are prone to fragility fractures, especially those suffering from type 2 diabetes mellitus (T2DM) combined with osteoporosis. Although studies have confirmed the association between GNRI and prevalence of osteoporosis, relationship fracture risk individualized 10-year probability osteoporotic fractures estimated by FRAX remains unclear. This study aims delve into a hip (HF) major (MOF) evaluated in T2DM.
Abstract We report the availability of a digitized Chinese male and digitzed female typical population with no obvious abnormalities. The embalming milling procedures incorporate three technical improvements over earlier cadavers. Vascular perfusion coloured gelatin was performed to facilitate blood vessel identification. Embalmed cadavers were embedded in cryosectioned whole so as avoid section loss resulting from cutting body into smaller pieces. Milling at −25 °C prevented small...
Transplantation of stem cells into damaged hearts has had modest success as a treatment for ischemic heart disease. One the limitations is poor cell survival in diseased microenvironment. Prolyl hydroxylase domain protein 2 (PHD2) cellular oxygen sensor that regulates key transcription factors involved and inflammation: hypoxia-inducible factor nuclear factor-κB.We studied whether how PHD2 silencing human adipose-derived (ADSCs) enhances their cardioprotective effects after transplantation...
To facilitate prostate cancer imaging using targeted molecules, we constructed ultrasonic nanobubbles coupled with specific anti-PSMA (prostate membrane antigen) nanobodies, and evaluated their in vitro binding capacity vivo efficacy. The "targeted" nanobubbles, which were via a biotin-streptavidin system, had an average diameter of 487.60 ± 33.55 nm carried the nanobody as demonstrated by immunofluorescence. Microscopy revealed to PSMA-positive cells. Additionally, ultrasonography...
The important role of angiogenesis in cancer development has driven many researchers to investigate the prospects noninvasive diagnosis based on technology contrast-enhanced ultrasound (CEUS) imaging. This paper presents a deep learning framework detect prostate sequential CEUS images. proposed method uniformly extracts features from both spatial and temporal dimensions by performing three-dimensional convolution operations, which captures dynamic information perfusion process encoded...
Abstract: In this study, the lipid targeted nanobubble carrying A10-3.2 aptamer against prostate specific membrane antigen was fabricated, and its effect in ultrasound imaging of cancer investigated. Materials including 2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphatidic acid, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine, 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol, carboxyl-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine,...
To explore the relationship between red blood cell distribution width to albumin (RDW/ALB) ratio (RAR) and risk of rehospitalization all-cause mortality in middle-aged elderly survivors with sepsis based on an ambispective longitudinal cohort from Intensive Care Unit (ICU).
Abstract The United States Visible Human Project (VHP) created a digital image data set of complete human male (data acquisition finished in November 1994) and female December 1995) cadavers magnetic resonance imaging (MRI), computed tomography (CT), anatomical (anatomic serial section) modes. VHP aroused worldwide enthusiasm for Research (VHR), the is being used variety research educational domains. Korean (VKH) was produced March 2001. To accelerate VHR to promote virtual anatomy as...
Stimuli-responsive nanoprobes that integrate multi-modal imaging capacities are highly desirable for precise tumor visualization.
Ultrasound (US)-targeted microbubble destruction has been widely used as an effective drug-delivery system. However, nanobubbles (NBs) have better stability and stronger penetration than microbubbles, drug delivery assisted by US-targeted NB (UTND) still needs to be investigated. Our aim was investigate the effect of doxorubicin (DOX) on inhibition prostate cancer growth under UTND. Contrast-enhanced US imaging transplanted PC3 in mice showed that a combination 1 W/cm(2) power 100 Hz...
The poor immunogenicity of solid tumors limits the efficacy ofanti-programmed cell death protein 1 (anti-PD1)-based immune checkpoint blockade (ICB); thus, less than 30% patients with cancer exhibit a response. Currently, there is still lack effective strategies for improving tumor immunogenicity.The antitumor effect ultrasound-stimulated nanobubbles (USNBs) alone and in combination an anti-PD1 antibody was evaluated RM1 (prostate cancer), MC38 (colon cancer) B16 (melanoma) xenograft mouse...
Prostate-specific membrane antigen (PSMA) is a highly specific biological marker and treatment target for prostate cancer. So ultrasound molecular imaging using PSMA antibody-loaded targeted nanoscale microbubbles (MBs) may contribute to the early diagnosis of cancer.PSMA monoclonal MBs were prepared biotin-avidin technology. Antibody binding was evaluated with immunofluorescence. Using MKN45 gastric cancer cells as controls, targeting capability observed in (LNCaP C4-2) under optical...
MicroRNA-106b (miR-106b) was recently identified as an oncogene participating in cancer progression. Transforming growth factor β1(TGF-β1) is indispensable cytokine regulating the local microenvironment, thereby promoting cervical However, roles of miR-106b carcinoma progression and TGF-β1-involvement tumorigenesis remain unknown. The expression human specimens detected by real-time PCR analysis situ hybridization assay. effect on cell migration analyzed scratch transwell assays. TGF-β1 used...
<b>Purpose:</b> To investigate the factors that influence enhancement patterns of intrahepatic cholangiocarcinomas (ICC) on contrast-enhanced ultrasound (CEUS) and analyze correlations between CEUS pathological findings. <b>Materials Methods:</b> Ninety-six patients with 96 pathologically confirmed ICCs underwent CEUS. images were retrospectively evaluated for tumor in arterial, portal late phases. The arterial correlated clinicopathological factors. possible influencing pathologic...
Abstract Traditional imaging examinations have difficulty in identifying benign and malignant changes renal masses. This may be solved by ultrasound molecular based on targeted nanobubbles, which could specifically enhance the of cell carcinomas (RCC) so as to discriminate In this study, we aimed prepare anti-G250 nanobody-functionalized nanobubbles (anti-G250 NTNs) coupling nanobodies lipid verify their target specificity binding ability RCC cells that express G250 antigen capacity...
Nanobubbles as a type of ultrasound contrast agent have attracted much interest in recent years due to their many advantages, such strong penetrating power and high stability. However, there is still insufficient morphological evidence concerning gas-filled nanobubbles tumor tissue spaces angiogenesis. We used gastric cancer xenograft an example study this question. with particle size 435.2 ± 60.53 nm were prepared compared SonoVue® microbubbles vitro vivo, they exhibited superior imaging...
Objective The objective of this study was to investigate nanobubbles carrying androgen receptor (AR) siRNA and their in vitro vivo anti-tumor effects, when combined with ultrasonic irradiation, on androgen-independent prostate cancer (AIPC). Materials Methods Nanobubbles AR were prepared using poly-L-lysine electrostatic adsorption methods. Using C4-2 cell activity as a testing index, the optimal irradiation parameters (including nanobubble number/cell number ratio, mechanical index [MI],...
Targeted nanobubbles can penetrate the tumor vasculature and achieve ultrasound molecular imaging (USMI) of parenchymal cells. However, most targeted only USMI cells from one organ, their distribution, loading ability, binding ability in tumors are not clear. Therefore, loaded with carbonic anhydrase IX (CAIX) aptamer were fabricated for various tumors, morphological basis was investigated.The specificity CAIX at cellular level measured by immunofluorescence flow cytometry. prepared a...