A5081793520- Ultrasound and Hyperthermia Applications
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Minerals Flotation and Separation Techniques
- Renal and related cancers
- Renal cell carcinoma treatment
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Ultrasound Imaging and Elastography
- Thyroid and Parathyroid Surgery
- Nanoparticle-Based Drug Delivery
- Ultrasound and Cavitation Phenomena
Army Medical University
2016-2025
Southwest Hospital
2016-2025
Southwest General Health Center
2016-2020
Daping Hospital
2020
Chongqing Medical University
2020
Southwest University
2020
State Key Laboratory of Silkworm Genomic Biology
2020
Abstract: In this study, the lipid targeted nanobubble carrying A10-3.2 aptamer against prostate specific membrane antigen was fabricated, and its effect in ultrasound imaging of cancer investigated. Materials including 2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphatidic acid, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine, 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol, carboxyl-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine,...
Ultrasound (US)-targeted microbubble destruction has been widely used as an effective drug-delivery system. However, nanobubbles (NBs) have better stability and stronger penetration than microbubbles, drug delivery assisted by US-targeted NB (UTND) still needs to be investigated. Our aim was investigate the effect of doxorubicin (DOX) on inhibition prostate cancer growth under UTND. Contrast-enhanced US imaging transplanted PC3 in mice showed that a combination 1 W/cm(2) power 100 Hz...
Abstract Traditional imaging examinations have difficulty in identifying benign and malignant changes renal masses. This may be solved by ultrasound molecular based on targeted nanobubbles, which could specifically enhance the of cell carcinomas (RCC) so as to discriminate In this study, we aimed prepare anti-G250 nanobody-functionalized nanobubbles (anti-G250 NTNs) coupling nanobodies lipid verify their target specificity binding ability RCC cells that express G250 antigen capacity...
Targeted nanobubbles can penetrate the tumor vasculature and achieve ultrasound molecular imaging (USMI) of parenchymal cells. However, most targeted only USMI cells from one organ, their distribution, loading ability, binding ability in tumors are not clear. Therefore, loaded with carbonic anhydrase IX (CAIX) aptamer were fabricated for various tumors, morphological basis was investigated.The specificity CAIX at cellular level measured by immunofluorescence flow cytometry. prepared a...
To construct prostate-specific membrane antigen (PSMA)-targeting, indocyanine green (ICG)-loaded nanobubbles (NBs) for multimodal (ultrasound, photoacoustic and fluorescence) imaging of prostate cancer.The mechanical oscillation method was used to prepare ICG-loaded NBs (ICG NBs). Then, PSMA-binding peptides were connected the surface ICG using biotin-avidin make targeted NBs, namely, PSMAP/ICG NBs. Their particle sizes, zeta potentials, in vitro ultrasound, fluorescence examined. Confocal...
We intended to design G250 antigen-targeting temsirolimus-loaded nanobubbles (G250-TNBs) based on the targeted drug delivery system and combine G250-TNBs with ultrasound nanobubble destruction (UTND) achieve a synergistic treatment for renal cell carcinoma (RCC).The filming-rehydration method was combined mechanical shock electrostatic interactions prepare (TNBs). were prepared by attaching anti-G250 nanobodies surface of TNBs using biotin-streptavidin-bridge method. The ability target...
Combining ultrasound imaging with photoacoustic provides tissue high contrast and resolution, thereby enabling rapid, direct measurements the tracking of tumour growth metastasis. Moreover, ultrasound-targeted nanobubble destruction (UTND) an effective way to deliver drugs, effectively increasing content drug in area reducing potential side effects, successfully contributing treatment tumours.In this study, we prepared multifunctional nanobubbles (NBs) carrying indocyanine green (ICG)...
Purpose: To construct nanobubbles (PTX-AMD070 NBs) for targeted delivery of paclitaxel (PTX) and AMD070, examine their performance in ultrasound molecular imaging breast cancer cervical therapeutic effect combined with nanobubble destruction (UTND). Materials methods: PTX-AMD070 NBs were prepared via an amide reaction, the particle size, zeta potential, encapsulation rate drug loading efficiency examined. Laser confocal microscopy flow cytometry used to analyze binding ability CXCR4 + MCF-7...
Ultrasound molecular imaging is a novel diagnostic approach for tumors, whose key link the construction of targeted ultrasound contrast agents. However, available agents tumors are only achieving in blood pool or one type tumor. No have realized tumor parenchymal cells variety solid so far. Carbonic anhydrase IX (CAIX) highly expressed on cell membranes various malignant it's good target imaging. Here, nanobubbles carrying CAIX polypeptides binding to were constructed, and ability effect...
To construct targeted nanobubbles carrying both small-molecule CXCR4 antagonist AMD070 and light-absorbing material indocyanine green (ICG), to study their in vitro multimodal imaging, as well mechanism efficacy of inhibition breast cancer cell growth. Nanobubbles ICG (ICG-TNBs) were constructed by carbodiimide reaction mechanical oscillation. The physical characteristics imaging determined. binding potential ICG-TNBs human cells observed laser confocal microscopy. CCK-8 flow cytometry used...
Abstract Background: Combining ultrasound imaging with photoacoustic provides tissue high contrast and resolution, thereby enabling rapid direct measurement tracking of tumor growth metastasis. At the same time, targeted nanobubble destruction (UTND) an effective way to drug accumulation; effectively increasing content in area reducing potential side effects, contributing treatment tumors. Result: In this study, we prepared multifunctional nanobubbles (NBs) carrying indocyanine green (ICG)...
Abstract Background: Combining ultrasound imaging with photoacoustic provides tissue high contrast and resolution, thereby enabling rapid, direct measurements the tracking of tumour growth metastasis. Moreover, ultrasound-targeted nanobubble destruction (UTND) an effective way to deliver drugs, effectively increasing content drug in area reducing potential side effects, successfully contributing treatment tumours. Results: In this study, we prepared multifunctional nanobubbles (NBs) carrying...