A5101441023- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Visual perception and processing mechanisms
- Psoriasis: Treatment and Pathogenesis
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Advanced Optical Imaging Technologies
- Ultrasound and Hyperthermia Applications
- Dermatology and Skin Diseases
- Attention Deficit Hyperactivity Disorder
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- interferon and immune responses
- Personality Disorders and Psychopathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Echinoderm biology and ecology
- Lipid metabolism and disorders
- Ultrasound and Cavitation Phenomena
- Suicide and Self-Harm Studies
- Cytokine Signaling Pathways and Interactions
- Cancer Mechanisms and Therapy
- Berberine and alkaloids research
- Intracranial Aneurysms: Treatment and Complications
- Liver physiology and pathology
Zhejiang University
2015-2025
Anhui Provincial Hospital
2025
Shenzhen KangNing Hospital
2023-2024
Jinzhou Kangning Hospital
2023-2024
Army Medical University
2006-2023
Southwest Hospital
2006-2023
Dalian Ocean University
2023
Ministry of Agriculture and Rural Affairs
2023
Blood Center of Zhejiang Province
2019-2022
First Affiliated Hospital Zhejiang University
2016-2022
Hepatitis B virus (HBV) is one of the major risk factors hepatocellular carcinoma (HCC). Increasing evidence indicates that microRNA (miRNA)–mRNA axis involved in HCC. However, a comprehensive miRNA–mRNA regulatory network HBV-related HCC still absent. This study aims to identify potential pathways contributing pathogenesis Microarray GSE69580 was downloaded from Gene Expression Omnibus (GEO) database. GEO2R and 'R-limma' were used conduct differential expression analysis. The common miRNAs...
We have cloned and characterized cDNAs encoding the zebrafish IGF ligands receptors. Sequence comparison showed that primary structures of IGF-I, IGF-II, IGF-I receptors (IGF-IRs) been highly conserved in vertebrates. In contrast to presence a single IGF-IR gene mammals, two distinct genes, termed igf-1ra igf-1rb, were found zebrafish. Structural phylogenetic analyses indicated both genes are orthologous human igf-1r gene. Immunoprecipitation studies with specific antibodies expressed bind...
Fish serum contains several specific binding proteins for insulin-like growth factors (IGFBPs). The structure and physiological function of these fish IGFBPs are unknown. Here we report the complete primary sequence a zebrafish IGFBP deduced from cDNA clones isolated by library screening rapid amplification ends. full-length 1,757-bp encodes protein 276 aa, which putative 22-residue signal peptide 254-residue mature protein. has predicted molecular size 28,440 Da shows high identity with...
Objective The aim of this study was to present the therapeutic outcome patients with locally advanced pancreatic cancer treated pancreatoduodenectomy combined vascular resection and reconstruction in addition highlighting mortality/morbidity main prognostic factors associated treatment. Materials Methods We retrospectively analyzed clinical pathological data a total 566 who were PD from five teaching hospitals during period December 2006–December 2011. This included 119 (21.0%)...
C-X-C motif chemokine ligand 2 (CXCL2) is a small secreted protein that exhibits structure similar to the proangiogenic subgroup of CXC family. Recently, accumulating evidence suggests chemokines play pivotal role in cancer progression and carcinogenesis. We examined expression levels 7 types ELR＋ CXCLs messenger RNA (mRNA) 264 clinical samples. found CXCL2 was stably down-regulated 94% hepatocellular carcinoma (HCC) specimens compared with paired adjacent normal liver tissues some HCC cell...
Osteosarcoma is the most common malignant tumor in skeletal system with high mortality. Phytic acid (PA) a natural compound extracted from plant seeds, which shows certain antitumor activity and good bone targeting ability. To develop novel theranostics for magnetic resonance imaging (MRI) therapy of osteosarcoma, we employed PA to modify manganese dioxide nanoparticles (MnO2@PA NPs) osteosarcoma treatment. The MnO2 NPs oligomer was formed by modification uniformed size distribution negative...
Insulin-like growth factor binding protein (IGFBP)-5 is a secreted that binds to IGF and modulates actions. IGFBP-5 also found in the nucleus of mammalian cells has transactivation activity. The structural basis this activity its role mediating IGF-independent actions are not clear. Here we report there 2 igfbp-5 genes zebrafish other teleost fish. In zebrafish, igfbp-5a -5b expressed spatially restricted, mostly nonoverlapping domains during early development. site conserved both IGFBP-5s,...
Background To date, no one-phase survey of childhood depression has been performed in China that involves both urban and rural community children. The objective this study was to determine the prevalence, correlates, mental health service utilization depressive disorders (DDs) a community-based sample 6–14-year-old children south-central China. Methods Children (3,582) were approached through multistage sampling interviewed using Chinese version Mini International Neuropsychiatric Interview...
Nanobubbles as a type of ultrasound contrast agent have attracted much interest in recent years due to their many advantages, such strong penetrating power and high stability. However, there is still insufficient morphological evidence concerning gas-filled nanobubbles tumor tissue spaces angiogenesis. We used gastric cancer xenograft an example study this question. with particle size 435.2 ± 60.53 nm were prepared compared SonoVue® microbubbles vitro vivo, they exhibited superior imaging...
Strongylocentrotus intermedius is one of the most economically valuable sea urchin species in China and has experienced mass mortality owing to outbreaks bacterial diseases such as black mouth disease. This caused serious economic losses farming industry. To investigate immune response mechanism S. with different tube feet colors Vibrio harveyi infection, we examined feet-colored under V. challenge compared their transcriptome microRNA (miRNA) profiles using RNA-Seq. We obtained 1813...
Abstract Background Risankizumab (RZB) is an interleukin 23p19 inhibitor approved for adults with moderately to severely active CD. In phase 3 trials, greater proportions of patients CD achieved clinical remission and endoscopic response RZB therapy vs placebo (PBO). This post hoc subanalysis evaluates the efficacy safety in Chinese from induction maintenance studies. Methods ADVANCE MOTIVATE were randomized, double-blind, PBO-controlled, Patients intolerance/inadequate biologic and/or...
The IL12B gene encodes the common p40 subunit of IL-12 and IL-23, cytokines with key roles in Th1 Th17 biology, respectively, genetic variation this region significantly influences risk psoriasis. Here, we demonstrate that a psoriasis-associated haplotype at locus leads to increased expression by monocytes correlated serum levels IL-12, IFN-γ induced chemokine, CXCL10. In contrast, IL-23 were decreased carriers when compared non-carriers. We further is psoriatic skin manifest skewing...
Abstract Purpose. To compare the efficacy of contrast‐enhanced pulse‐inversion harmonic sonography for characterization focal liver lesions with that helical CT. Methods. Real‐time (CEUS) using Sonovue and CT (CECT) were performed on 109 patients lesions, including 61 hepatocellular carcinomas, 15 metastases, 5 cholangiocellular 12 hemangiomas, regenerative nodules, 3 adenomas, nodular hyperplasias, 4 necroses, 1 angiomyolipoma prior to surgery or percutaneous needle biopsy. The diagnostic...
Heterozygosity for the Pax6 allele is associated with impaired glucose tolerance in humans. With a mutant mouse model, we found many of metabolic abnormalities were consistent effects down-regulating expression glucagon-like peptide 1 (GLP-1). In addition to tolerance, adult heterozygous mice (Pax6m/+) secreted less insulin responding and arginine administration compared control mice. Moreover, Pax6m/+ showed increased food intake mice, although they resistant diet-induced fat accumulation....
Metabolic reprogramming, such as alterations in glutamine metabolism or glycolysis, is the hallmark of hepatocellular carcinoma (HCC). However, underlying mechanisms are still incompletely elucidated. Previous studies have identified that methyltransferase SET and MYND domain-containing protein 2(SMYD2) responsible for pathogenesis numerous types cancer. Here, we innovatively uncover how SMYD2 regulates HCC cells promotes progression. We expression upregulated tissues, which correlates with...
To investigate the potential oncogene promoting recurrence of hepatocellular carcinoma (HCC) following liver transplantation (LT), throughput RNA sequencing was performed in a subgroup HCC patients. The up-regulated FAM83D tissues found and further verified 150 patients by real-time PCR immunohistochemistry. overexpression significantly correlated with high rate LT poor characteristics such as AFP, differentiation. Of cancer stem cells (CSCs) markers, CD44 expression effectively suppressed...
Inhibitors of the CDK family proteins have been approved for treatment a variety tumours; however, development new drugs administered in combination with inhibitors is expected to improve therapeutic effect.We identified function suppressor cytokine signalling 1 (SOCS1) hepatocellular carcinoma (HCC) cell models and xenograft mouse model.When SOCS1 expression was artificially upregulated, HCC lines were arrested at G1-S transition cycle.Interestingly, during this process, total CyclinD1...
Background: Synthesized dl-Nordihydroguaiaretic acid (dl-NGDA or “Nordy”) can inhibit the growth of malignant human tumors, especially tumor angiogenesis. However, its liposoluble nature limits in vivo efficacy hydrosoluble circulation human.Purpose: We tried to use ultrasonic microbubble as carrier and ultrasound-induced destruction for targeted release Nordy evaluate vitro anti-tumor effect.Methods: Nordy-loaded lipid microbubbles were prepared by mechanical vibration. Effects on...