A5086965966- Phytochemistry and Biological Activities
- Influenza Virus Research Studies
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- RNA and protein synthesis mechanisms
- Natural product bioactivities and synthesis
- Botanical Studies and Applications
- Plant-derived Lignans Synthesis and Bioactivity
- Phytochemical Studies and Bioactivities
- Medicinal plant effects and applications
- Phytochemical and Pharmacological Studies
- Adsorption and biosorption for pollutant removal
- Phytochemistry and Bioactive Compounds
- Pharmacological Receptor Mechanisms and Effects
- Plant chemical constituents analysis
- Phosphodiesterase function and regulation
- Pharmacological Effects and Assays
- Click Chemistry and Applications
- Antimicrobial Peptides and Activities
- Viral Infections and Outbreaks Research
- Carbohydrate Chemistry and Synthesis
- Biosensors and Analytical Detection
- Cholinesterase and Neurodegenerative Diseases
- Phytochemical compounds biological activities
- Magnolia and Illicium research
Huanghuai University
2019-2024
Hebei Normal University
2023
Chinese Academy of Sciences
2015-2018
Guangzhou Institutes of Biomedicine and Health
2015-2018
State Key Laboratory of Respiratory Disease
2015
State Council of the People's Republic of China
2015
Although recent decades have witnessed the synthesis of 1,3,4-thiadiazoles via phosphorus POCl3-promoted cyclization reaction, simultaneous access to 2-amino-1,3,4-thiadiazole and 2-amino-1,3,4-oxadiazole analogs remains unexpected elusive. Herein, a detailed regiocontrolled 2-amino-1,3,4-thiadiazoles in good high yields with regioselectivities from readily available thiosemicarbazides using POCl3 was disclosed. Meantime, establish comprehensive structure–activity relationship, derivatives...
Influenza pandemic is a constant major threat to public health caused by influenza A viruses (IAVs). IAVs are subcategorized the surface proteins hemagglutinin (HA) and neuraminidase (NA), in which they both essential targets for drug discovery. While it of great concern that NA inhibitor oseltamivir resistant strains frequently identified from human or avian virus, structural functional characterization HA has raised hopes new antiviral therapies. In this study, we explored...
Depression severely impairs the health of people all over world. Cognitive dysfunction due to depression has resulted in a severe economic burden family and society induced by reduction social functioning patients. Norepinephrine-dopamine reuptake inhibitors (NDRIs) targeted with human norepinephrine transporter (hNET) distributed dopamine (hDAT) simultaneously treat improve cognitive function, they effectively prevent sexual other side effects. Because many patients continue poorly respond...
Amantadine derivatives have been the only drugs marketed as M2 inhibitors of influenza A for decades.
The fruit of Hippophae rhamnoides L. is not only used as delicious food with nutritional values, but also served traditional Chinese medicine multiple bioactivities.
The fruit of Hippophae rhamnoides L. has been used for centuries in Europe and Asia as a food with high nutritional medicinal values. In this study, bioactivity-guided phytochemical investigation H. resulted four new dimethylallylated flavonolignans (1–4), isopropylpentenone–flavonolignan heterodimers (5–8), two geranylated (9 10), 14 known flavonolignan derivatives (11–24); they were elucidated by their spectrometric spectroscopic methods, including HR-ESI-MS, NMR, IR, UV from the first...
Two new lignans, 3,4-(10-methoxy-phenylallyl)-9″-((10'-isopropanol-3',4'-furan)-phenylacetyl)-8″-dioxane-7″-O-β-d-glucopyranoside (1), 3,4-benzolactone-9″-((12'-isopropanol-3',4'-furan)-phenylbutenone)-8″-dioxane-7″-O-β-d-glucopyranoside (2), and nine known lignan derivatives (3-11) were isolated from the flower buds of Magnolia biondii Pamp. for first time. Their structures elucidated by 1D 2D NMR, UV, IR, MS data, as well comparison with those references. Compounds (1-11) evaluated their...
Positive allosteric modulators (PAMs) of human metabotropic glutamate receptor 2 (hmGlu2) are well-known in the treatment psychiatric disorders for their higher selectivity and lower tolerance risk. A variety PAMs have been reported over last decade two compounds were Phase II clinical trials schizophrenia anxiety. These discontinued on account unsatisfactory therapeutic efficacy, but explored as novel treatments addiction epilepsy. Thus, it is still important to explore hmGlu2 near future....
Indole-3-acetonitrile-6- O-β-d-glucopyranoside 1 is a simple alkaloid with anti-influenza A virus activity extracted from Radix isatidis. Herein, concise and practical total synthetic route of was presented, starting 6-benzyloxyindole on multigram scale. The pivotal reaction sequence involved the Mannich reaction, fluoride ion-induced elimination-addition phase-transfer-catalyzed glycosylation as key steps. In addition, compounds two modified derivatives 8 16 were tested for efficacy...
To study phenylpropanoids from Eleocharis dulcis and their hepatoprotective activities. The compounds were separated purified ethyl acetate part by conventional column chromatography preparative liquid chromatography, structures identified various spectral techniques. HL-7702 cells damage model of hepatocytes induced APAP was used to screen evaluate the activities these compounds. Sixteen isolated E. dulcis, as...