A5101408685- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- Cardiac Structural Anomalies and Repair
- Immune Response and Inflammation
- interferon and immune responses
- Respiratory viral infections research
- Cardiac and Coronary Surgery Techniques
- Electrospun Nanofibers in Biomedical Applications
- Respiratory Support and Mechanisms
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Andrographolide Research and Applications
- Angiogenesis and VEGF in Cancer
- Microbial Metabolism and Applications
- Pneumonia and Respiratory Infections
- Inflammasome and immune disorders
- Fungal Biology and Applications
- Monoclonal and Polyclonal Antibodies Research
- Mesenchymal stem cell research
- Phytochemistry and Biological Activities
- Microbial Metabolites in Food Biotechnology
- Immune Cell Function and Interaction
Mongolian University of Science and Technology
2025
Inner Mongolia University of Science and Technology
2024
First Affiliated Hospital of Guangzhou Medical University
2015-2024
Guangzhou Medical University
2015-2024
State Key Laboratory of Respiratory Disease
2015-2024
China Huadian Corporation (China)
2024
Qingzhou City People's Hospital
2009-2024
Guangzhou Experimental Station
2023
Zhongshan People's Hospital
2007-2021
Sun Yat-sen University
2012-2021
Abstract Although vaccines are available for SARS-CoV-2, antiviral drugs such as nirmatrelvir still needed, particularly individuals in whom less effective, the immunocompromised, to prevent severe COVID-19. Here we report an α-ketoamide-based peptidomimetic inhibitor of SARS-CoV-2 main protease (M pro ), designated RAY1216. Enzyme inhibition kinetic analysis shows that RAY1216 has constant 8.4 nM and suggests it dissociates about 12 times slower from M compared with nirmatrelvir. The...
Coronavirus Disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), which enter the host cells through interaction between its receptor binding domain (RBD) of spike glycoprotein with angiotensin-converting enzyme (ACE2) on plasma membrane cell. Neutralizing antibodies and peptide binders RBD can block viral infection, however, concern accessibility affordability infection inhibitors has been raised. Here, we report identification natural compounds as potential...
Isatis indigotica Fort. (Ban-Lan-Gen) is an herbal medicine prescribed for influenza treatment. However, its active components and mode of action remain mostly unknown. In the present study, erucic acid was isolated from Fort., subsequently underlying mechanism against A virus (IAV) infection investigated in vitro vivo. Our results demonstrated that exhibited broad-spectrum antiviral activity IAV resulting reduction viral polymerase transcription activity. Erucic found to exert inhibitory...
Exosomes are a subgroup of extracellular vesicles that naturally released by almost all types cells. However, the factors promote capacity natural killer (NK) cells to release exosomes unclear. In this study, we investigated whether hypoxia can enhance yield NK cell-derived and improve immunotherapeutic effects these cells.Exosomes from NK92 or NK92-hIL-15 were isolated culture medium under normoxic (NK92-Exo NK92-hIL-15-Exo) hypoxic (hypoxic NK92-Exo conditions. characterized transmission...
Scutellariae radix ("Huang-Qin" in Chinese) is a well-known traditional herbal medicine and popular dietary supplement the world, extensively used prescriptions of TCMs as adjuvant treatments for coronavirus pneumonia 2019 (COVID-19) patients China. According to differences its appearance, can be classified into two kinds: ZiQin (1∼3 year-old baicalensis with hard roots) KuQin (more than 3 S. withered pithy roots). In accordance clinical theory TCM, superior cooling down heat lung. However,...
Abstract Enzymes, serving as eco-friendly catalysts, are progressively supplanting traditional chemical catalysts in light industry sectors such feed, papermaking, textiles, detergents, leather, and sugar production. Despite this advancement, the variability performance of natural enzymes fragmentation diversity existing data formats pose significant challenges to researchers. Furthermore, AI-driven enzyme design is limited by quality quantity available data. To address these issues, we...
Abstract SARS-CoV-2 has demonstrated extraordinary ability to evade antibody immunity by antigenic drift. Small molecule drugs may provide effective therapy while being part of a solution circumvent immune escape. In this study we report an α-ketoamide based peptidomimetic inhibitor main protease (M pro ), RAY1216. Enzyme inhibition kinetic analysis established that RAY1216 is slow-tight with K i 8.6 nM; drug-target residence time 104 min compared 9 PF-07321332 (nirmatrelvir), the antiviral...
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with high mortality rates. Viral and bacterial coinfection the primary cause AECOPD. How these microbes influences host inflammatory response gut microbiota composition not entirely understood.We developed a mouse model AECOPD by cigarette smoke exposure sequential infection influenza H1N1 virus non-typeable Haemophilus influenzae (NTHi). titer was determined using MDCK cells chocolate agar plates,...
Influenza pandemic is a constant major threat to public health caused by influenza A viruses (IAVs). IAVs are subcategorized the surface proteins hemagglutinin (HA) and neuraminidase (NA), in which they both essential targets for drug discovery. While it of great concern that NA inhibitor oseltamivir resistant strains frequently identified from human or avian virus, structural functional characterization HA has raised hopes new antiviral therapies. In this study, we explored...
Influenza B virus (IBV) is one of the main pathogens annual influenza epidemic, and disease burden significant, especially among children young teenagers. In this study, antiviral anti-inflammatory effects a traditional Chinese medicine prescription, Lianhua-Qingwen capsule, were evaluated. Our results showed that capsule can inhibit both Victoria Yamagata lineages, 50% inhibitive concentrations ranged from 0.228 ± 0.150 to 0.754 0.161 mg/mL. The time course demonstrated IBV yields reduced...
We compared the success of preoperative hook wire localization pulmonary pure ground-glass opacities (pGGOs) with intraoperative palpation during video-assisted thoracoscopic (VAT) surgery and examined safety method.A total 39 patients 41 pGGOs less than 2 cm in diameter underwent guided by DSA Innova CT before VAT lesion resection. The relationship between localization, as determined finger or wire, clinicopathological factors was analyzed retrospectively. Complications resulting from are...
Abstract SARS-CoV-2 has demonstrated extraordinary ability to evade antibody immunity by antigenic drift. Small molecule drugs may provide effective therapy while being part of a solution circumvent immune escape. In this study we report an α-ketoamide based peptidomimetic inhibitor main protease (Mpro), RAY1216. Enzyme inhibition kinetic analysis established that RAY1216 is slow-tight with Ki 8.6 nM; drug-target residence time 104 min compared 9 PF-07321332 (nirmatrelvir), the antiviral...