A5102799442- Catalytic C–H Functionalization Methods
- Magnolia and Illicium research
- Oxidative Organic Chemistry Reactions
- Phytochemicals and Antioxidant Activities
- Synthesis and Biological Evaluation
- Radical Photochemical Reactions
- Cancer therapeutics and mechanisms
- Catalytic Alkyne Reactions
- Cyclopropane Reaction Mechanisms
- Natural product bioactivities and synthesis
- Organic Chemistry Cycloaddition Reactions
- Multicomponent Synthesis of Heterocycles
- Bioactive Compounds and Antitumor Agents
- Asymmetric Synthesis and Catalysis
- Cancer, Hypoxia, and Metabolism
- Synthesis and bioactivity of alkaloids
- Phytochemistry and Biological Activities
- Synthesis of Indole Derivatives
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Fungal Plant Pathogen Control
- Antimicrobial Resistance in Staphylococcus
- Phytochemical compounds biological activities
- Plant-derived Lignans Synthesis and Bioactivity
- Hops Chemistry and Applications
University of South China
2024-2025
Macau University of Science and Technology
2020-2024
South China Agricultural University
2024
Zhengzhou University
1993-2022
Henan University
2022
Nantong University
2022
Jiangsu Normal University
2016-2022
Southwest University
2020-2022
Xuchang University
2022
Nanchang Hangkong University
2021
The escalation of multidrug-resistant bacterial infections, especially infections caused by methicillin-resistant Staphylococcus aureus (MRSA), underscores the urgent need for novel antimicrobial drugs. Here, we synthesized a series amphiphilic 2-phenyl-1H-phenanthro[9,10-d]imidazole-antimicrobial peptide (AMP) mimic conjugates (III1–30). Among them, compound III13 exhibited excellent antibacterial activity against G+ bacteria and clinical MRSA isolates (MIC = 0.5–2 μg/mL), high membrane...
Infections caused by multidrug-resistant (MDR) bacteria are increasing worldwide, and with limited clinically available antibiotics, it is urgent to develop new antimicrobials combat these MDR bacteria. Here, a class of novel amphiphilic xanthohumol derivatives were prepared using building-block approach. Bioactivity assays showed that the molecule IV15 not only exhibited remarkable antibacterial effect against clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates (MICs: 1–2...
Infections with methicillin-resistant
Silver-mediated isocyanide-alkyne [3 + 2] cycloaddition has been developed as a new method for the synthesis of pyrroles. Density functional theory (DFT) calculations toward this reaction reveal that terminal alkynes participated cycloadditions proceed through two successive 1,5-silver migrations, in which silver migrates between carbon atoms and finally returns to original carbon. Natural population analysis (NPA) indicates migration guides move charge into rational way, thereby...
A radical-mediated three-component 1,4-sulfonylarylation of 1,3-enynes with aryl iodides and sulfinate salts using cooperative photoredox/nickel catalysis is described. This protocol enables the synthesis tetrasubstituted sulfonyl-containing allenes under redox-neutral conditions provides a versatile 1,3-enyne 1,4-difunctionalization platform for diverse range high chemo- regioselectivities, excellent functional group tolerance, broad substrate scope.
A new and highly eco-friendly approach to diverse functionalized oxazolo[5,4-b]indoles with good yield high diastereoselectivity (up >99:1) has been disclosed from simple readily available arylglyoxals cyclic enaminones amino acids. These microwave-assisted transformations in environmentally compatible ethanol resulted continuous multiple bond-forming events including C–C, C–N, C–O bonds, enabling catalyst-free multicomponent bicyclizations rapidly build up functional N,O-heterocycles.
A novel photoredox catalysis for multiple functionalization of two different types unactivated alkenes in a single operation was reported through conceptually new mode annulation-alkynyl migration. wide array cyclopentane carboxylates were synthesized highly selective and functional-group-compatible manner via C-centered radical induced cascade 5-exo-trig/5-exo-dig bicyclization C-C bond cleavage process. This methodology might open entry designing annulation-functional group migration to...
Comprehensive Summary Developing reactions for the synthesis of 6‐6‐4 and 6‐4 carbocyclic scaffolds with a chiral quaternary center at bridgehead position is highly desired, considering existence such skeletons in natural products biological activities potential using these molecules downstream studies chemical biology medicinal chemistry. Report here accessing target high chemo‐, regio‐ enantio‐selectivities through Pd(II)/chiral N , ’‐disulfonyl bisimidazoline (Bim) ligand‐catalyzed...
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of hospital- and community-acquired infections, necessitating the development novel antibacterials. Here, we designed synthesized 30 osthole derivatives with pyridinium quaternary ammonium moieties. In vitro bioassay showed that compounds 8u 8ac exhibited potent antibacterial activity against S. ATCC 29213 ten clinical MRSA isolates (MIC = 0.5-1 μg/mL), low hemolytic activity, rapid bactericidal effects, minimal resistance...
Pd-catalyzed selective amine-oriented C8-H bond functionalization/N-dealkylative carbonylation of naphthyl amines has been achieved. The amine group from dealkylation is proposed to be the directing for promoting this process. It represents a straightforward and easy method access various biologically important benzo[cd]indol-2(1H)-one derivatives.
Scutellariae radix ("Huang-Qin" in Chinese) is a well-known traditional herbal medicine and popular dietary supplement the world, extensively used prescriptions of TCMs as adjuvant treatments for coronavirus pneumonia 2019 (COVID-19) patients China. According to differences its appearance, can be classified into two kinds: ZiQin (1∼3 year-old baicalensis with hard roots) KuQin (more than 3 S. withered pithy roots). In accordance clinical theory TCM, superior cooling down heat lung. However,...
A series of well-defined phosphine-ligated diarylgold(III) complexes cis-[Au(L)(ArF)(Ar′)(Cl)] were prepared, and detailed kinetics the C(sp2)–C(sp2) reductive elimination from these studied. The mechanism was further studied by theoretical calculations. combination experimental results suggests that biaryl organogold(III) proceeds through a concerted biaryl-forming pathway four-coordinated Au(III) metal center. These studies also disclose steric hindrance phosphine ligands plays major role...
A new double annulation cascade involving a [2 + 2] cycloaddition-retroelectrocyclization (CA-RE) process was first reported, leading to the generation of unprecedented dibenzoannulated naphtho[2,1-b]oxecines with good excellent yields and high stereoselectivity through catalytic scission/recombination C-C bonds under mild conditions. An Y(OTf)3-catalyzed three-component reaction α-alkynyl naphthalen-2-ols β,γ-unsaturated α-ketoesters enabled direct ring expansion naphthalene carbon-carbon...
A new Lewis acid catalyzed alkyne–carbonyl metathesis/oxa-Michael addition relay was first reported, leading to the atom-economic synthesis of unreported functionalized indolone-containing naphtho[2,1-b]furan-1-ones with a quaternary center in good excellent yields and high diastereoselectivity through scission/recombination C–O double bonds under mild conditions. Yb(OTf)3-catalyzed reaction between α-alkynyl naphthalen-2-ols isatins worked efficiently offered convergent regioselective...
A new and green route to skeletally diverse oxo-heterocyclic architectures such as pyrano[3,4-c]chromen-2-ones pyrano[3,4-c]quinolin-2-ones is reported via an unprecedented photocatalytic Kharasch-type cyclization/1,5-(SN″)-substitution/elimination/6π-electrocyclization/double nucleophilic substitution cascade starting from easily available heteroatom-linked 1,7-diynes low-cost CBrCl3. During this reaction process, the full scission of carbon-halogen bonds BrCCl3 was realized directly build...
Hawk tea (Litsea coreana Levl. var. lanuginosa) is a traditional herbal in southwestern China, and was found to possess hepatoprotective effects our previous study. However, it unclear whether hawk flavonoids (HTF) can alleviate alcoholic liver damage (ALD). Firstly, we extracted identified the presence of 191 molecules categorized as HTFs, with reynoutrin, avicularin, guaijaverin, cynaroside, kaempferol-7-O-glucoside being most prevalent. After taking bioavailability into consideration...