A5101615049- Catalytic C–H Functionalization Methods
- Molecular Sensors and Ion Detection
- Cyclopropane Reaction Mechanisms
- Catalytic Alkyne Reactions
- Drug Transport and Resistance Mechanisms
- Asymmetric Hydrogenation and Catalysis
- Catalytic Cross-Coupling Reactions
- Advanced biosensing and bioanalysis techniques
- Sulfur Compounds in Biology
- Nanoparticle-Based Drug Delivery
- Synthesis and Catalytic Reactions
- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Microbial Metabolic Engineering and Bioproduction
- Bone health and treatments
- HIV/AIDS drug development and treatment
- Neuroscience and Neuropharmacology Research
- Sulfur-Based Synthesis Techniques
- Neonatal Health and Biochemistry
- Bone Metabolism and Diseases
- Cancer Cells and Metastasis
- Oxidative Organic Chemistry Reactions
- Computational Drug Discovery Methods
Harbin Medical University
2021-2025
Guangxi University
2016-2025
Third Affiliated Hospital of Harbin Medical University
2025
Shanghai University of Traditional Chinese Medicine
2017-2024
Guangxi Medical University
2019-2024
Yueyang Hospital
2022-2024
Lanzhou University
2022
Shuguang Hospital
2017-2021
Nanning Normal University
2015-2019
Guizhou Provincial People's Hospital
2019
Transition metal-catalyzed skeletal rearrangement reactions have rapid advances in organic community. Their development benefits synthetic methodologies by providing versatile and flexible approaches toward special molecular scaffolds with high selectivity. Herein, a gold-catalyzed of alkenes alkynyl bromides is reported, enabling direct regioselective generation more than 50 examples skeletally diverse tricyclic heterocycles, namely, syn-tetrahydrocyclopenta[b]indoles...
Comprehensive Summary Developing reactions for the synthesis of 6‐6‐4 and 6‐4 carbocyclic scaffolds with a chiral quaternary center at bridgehead position is highly desired, considering existence such skeletons in natural products biological activities potential using these molecules downstream studies chemical biology medicinal chemistry. Report here accessing target high chemo‐, regio‐ enantio‐selectivities through Pd(II)/chiral N , ’‐disulfonyl bisimidazoline (Bim) ligand‐catalyzed...
A highly efficient P–H insertion of α-imino copper carbene into H-phosphine oxides, leading to 3-phosphinoylindoles with a broad substrate diversity and good chemoselectivity, is established. This methodology provides rapid approach for the C (sp2)–P bond formation via strategy. The stereoselective represents unique example asymmetric insertion, affording P-stereogenic high stereoselectivities.
Diastereoselective aerobic dehydrogenative cyclization of hydrazones is described <italic>via</italic> a copper-catalyzed sp<sup>3</sup> C–H functionalization process.
The aim of this study was to optimize the dose regimens enrofloxacin reduce development fluoroquinolone resistance in Escherichia coli (E.coli) using pharmacokinetic/pharmacodynamic (PK/PD) modeling approach. single (2.5 mg/kg body weight) administered intramuscularly (IM) healthy pigs. Using cannulation, pharmacokinetic properties, including peak concentration (C max), time reach C max (T and area under curve (AUC), were determined plasma ileum content. max, T AUC 1.09 ± 0.11 μg/mL, 1.27...
An unusual catalytic double [2 + 2] cycloaddition relay reaction of yne–allenones with unactivated alkenes and alkynes has been achieved, which enabled C–C triple-bond cleavage to access more than 60 examples functionalized phenanthren-9-ols generally good yields. This provides a regioselective practical method for the construction carbocyclic ring systems high degree functional group compatibility. Aside from surveying scope this transformation, mechanistic details process are provided by...
Interleukin-8 (IL-8) is an 8 kD chemokine and angiogenic factor produced by alveolar macrophages, endothelial cells, monocytes, fibroblasts. T lymphocytes, epithelial cells in response to a variety of stimuli, including LPS, TNF-α, IL-1, IL-7, hypoxia. Pulmonary tumors produce growth factors cytokines that may act both autocrine paracrine fashion. A549, well-characterized human lung adenocarcinoma line, was cloned for different levels IL-8 production limiting dilution. Clone 3B4 361 ± 73...
Alzheimer's disease (AD) is a neurodegenerative disorder that affects approximately 35 million people worldwide, and diet has been reported to influence the prevalence/incidence of AD. Colorectal cancer among most common cancers in Western populations, correlation between constipation occurrence colorectal identified number studies, which show Westernized mutual risk factor. Constipation growing health problem, particularly middle-aged older adults. As gastrointestinal adults, 2-20% world...
One antitumor β-elemene derivative W-105 and three novel hepatocyte-targeting prodrugs (W-1-5, W-2-9, W-3-8) were designed synthesized. (IC50 6.107 μM) could cause cell apoptosis through upregulating the activity of caspase-3. The capacities aimed compounds followed (parent compound) < W-1-5 (monodentate-galactose) W-2-9 (bidentate-galactose) W-3-8 (tridentate-galactose) order, which is attributed to excellent affinity galactose ligand ASGPR galactose-cluster recognition effect. Furthermore,...
A fundamental computational problem in metabolic engineering is to find pathways between compounds. Pathfinding methods using atom tracking have been widely used biochemically relevant pathways. However, these require the user define atoms be tracked. This may lead failing predict that do not conserve user-defined atoms. In this work, we propose a pathfinding method called AGPathFinder two given AGPathFinder, alternative by movement of atomic groups through networks and use combined...