A5017214604- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neurological Disorders and Treatments
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Neurosurgical Procedures and Complications
- RNA Research and Splicing
- GDF15 and Related Biomarkers
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Circular RNAs in diseases
- RNA regulation and disease
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Acupuncture Treatment Research Studies
- Apelin-related biomedical research
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and genetic disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Autophagy in Disease and Therapy
- Nutrition, Genetics, and Disease
Third Xiangya Hospital
2016-2025
Central South University
2016-2025
Xiangya Hospital Central South University
2008-2020
Background: Large hemispheric infarction (LHI) shows a high risk of cerebral edema and neurological deterioration, even leading to death, but it still has limited treatment options. HRS8179 is selective sulfonylurea receptor 1 inhibitor, which can block the up-regulated sodium channel after ischemic stroke reduce edema. This study assessed in patients with large infarction. Methods: In this multicenter, randomized, double-blinded, placebo-controlled, phase 2 clinical trial (NCT05690711), who...
Background Alzheimer disease (AD) is a neurodegenerative related to aging. At present, its pathological mechanisms remain unclear. Family members of the renin-angiotensin system (RAS) play role in neuronal plasticity, as well formation learning and memory. In this study, we explore effects altered angiotensin-converting enzyme (ACE), investigate possible perindopril, an ACE inhibitor, on brain structure function rat model AD, that plays AD. Methods Sixty Sprague-Dawley rats were selected...
Alzheimer's disease (AD) is a neurodegenerative disorder that affects approximately 35 million people worldwide, and diet has been reported to influence the prevalence/incidence of AD. Colorectal cancer among most common cancers in Western populations, correlation between constipation occurrence colorectal identified number studies, which show Westernized mutual risk factor. Constipation growing health problem, particularly middle-aged older adults. As gastrointestinal adults, 2-20% world...
In recent years, researchers have found that adiponectin (ANP) plays an important role in the pathogenesis of Alzheimer's disease (AD), and low serum concentrations ANP are associated with AD. Higher plasma level a protective effect against development cognitive decline, suggesting may affect AD onset. Meanwhile, accumulating evidence supports crucial To study relationship between gene polymorphisms (rs266729, -11377C>G rs1501299, G276T) late-onset (LOAD), we carried out case-control...
inhibition of acetylcholinesterase (AChE) has been a effective treatment for Alzheimer's disease (AD). Octohydroaminoacridine, new AChE inhibitor, is potential AD.we conducted multicenter, randomised, double blind, placebo-controlled, parallel-group Phase II clinical trial to investigate the effects octohydroaminoacridine in patients with mild-to-moderate AD. Patients were randomised receive placebo thrice daily, 1 mg/thrice daily (TID) (low-dose group), 2 mg/TID (middle-dose group) or 4...
Background/Aims: To investigate the roles of oxidative stress related-genes ALOX5, ALOX5AP and MPO in ischemic stroke susceptibility Han Chinese population. Methods: A total 351 patients 417 controls were recruited. The ALOX5 rs10900213, rs4293222 rs2107545 gene polymorphisms genotyped. Results: We identified that was significantly associated with after adjusting for covariates. Furthermore, we also considered likely complexity inflammatory process by assessing combined effects multiple...
Alzheimer’s disease (AD) is a complex, and multifactorial neurodegenerative disease. Previous studies have revealed that oxidative stress, synaptic toxicity, autophagy, neuroinflammation play crucial roles in the progress of AD, however, its pathogenesis still unclear. Recent researches indicated ferroptosis, an iron-dependent programmed cell death, might be involved AD. Therefore, we aim to screen correlative ferroptosis-related genes (FRGs) AD clarify insights into diagnostic value....
As the incidence of Alzheimer's disease (AD) increases year by year, more people begin to study this disease. In recent years, many studies on reactive oxygen species (ROS), neuroinflammation, autophagy, and other fields have confirmed that hypoxia is closely related AD. However, no researchers used bioinformatics methods relationship between AD hypoxia. Therefore, our aimed screen role hypoxia-related genes in clarify their diagnostic significance. A total 7681 differentially expressed...
<b><i>Background:</i></b> Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal-dominant, inherited, systemic, vascular disorder primarily involving the small arteries. It characterized by migraine, recurrent ischemic strokes, cognitive decline, dementia. Mutations in Notch receptor 3 gene (<i>NOTCH</i>3) HtrA serine peptidase 1 (<i>HTRA1</i>) are 2 genetic causes for CADASIL. The...
Obesity is a well-established risk factor for large artery atherosclerotic (LAA) stroke. The aim of the study was to explore whether obesity genes, such as MC4R and FTO, contribute LAA stroke in Chinese Han population.322 patients 473 controls were recruited. Gene polymorphism (rs17782313) FTO (rs8050136 rs9939609) genotyped.No differences observed genotype frequencies variants or between control subjects. However, rs17782313 gene associated with susceptibility smokers (rs17782313: p =...