A5101728463- Parkinson's Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience and Neuropharmacology Research
- Bariatric Surgery and Outcomes
- Neurological disorders and treatments
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Autism Spectrum Disorder Research
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Autonomous Vehicle Technology and Safety
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Oral and gingival health research
- Smart Parking Systems Research
- Biological and pharmacological studies of plants
- Diabetic Foot Ulcer Assessment and Management
- Nuclear Receptors and Signaling
- RNA Research and Splicing
- Glycogen Storage Diseases and Myoclonus
- ATP Synthase and ATPases Research
- Alkaloids: synthesis and pharmacology
- Reproductive Biology and Fertility
- Airway Management and Intubation Techniques
Central South University
2012-2024
Third Xiangya Hospital
2012-2024
Nanyang Technological University
2024
There has been renewed interest in using mitochondrial uncoupler compounds such as niclosamide and carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone (FCCP) for the treatment of obesity, hepatosteatosis diseases where oxidative stress plays a role. However, both FCCP have undesirable effects that are not due to uncoupling, inhibition oxygen consumption by induction DNA damage niclosamide. Through structure-activity analysis, we identified analogues do inhibit but still provided good,...
This paper was designed to investigate anticonvulsant and sedative effects of eudesmin isolated from Acorus tatarinowii . The (5, 10, 20 mg/kg) administered intraperitoneally (i.p.). maximal electroshock test (MES) pentylenetertrazole (PTZ)‐induced seizures in male mice were used evaluate activities eudesmin, evaluated by pentobarbital sodium‐induced sleeping time (PST) locomotor activity mice. Finally, the mechanisms investigated determining contents glutamic acid (Glu) gamma‐aminobutyric...
Alzheimer's disease (AD) is a neurodegenerative disorder that affects approximately 35 million people worldwide, and diet has been reported to influence the prevalence/incidence of AD. Colorectal cancer among most common cancers in Western populations, correlation between constipation occurrence colorectal identified number studies, which show Westernized mutual risk factor. Constipation growing health problem, particularly middle-aged older adults. As gastrointestinal adults, 2-20% world...
Background: Obesity is a widely recognized global public health issue, and bariatric surgery has emerged as an effective intervention for alleviating obesity associated complications. However, the impact of on male reproductive function remains inconclusive in literature. The current understanding laparoscopic sleeve gastrectomy ambiguous, despite its status most commonly performed surgery. This prospective cohort study aimed to investigate erectile semen quality. Patients Methods: A total...
Early-onset epilepsy following ischemic stroke is a severe neurological condition, the pathogenesis of which remains incompletely understood. Recent studies suggest that Neural stem/progenitor cells (NSPCs) play crucial role in disease process, yet precise molecular mechanisms regulating NSPCs have not been thoroughly investigated. This study utilized single-cell transcriptome sequencing and bioinformatics analysis to identify disease-related genes, were subsequently validated both vitro...
The diagnostic criteria for Parkinson's disease (PD) remain complex, which is especially problematic nonmovement disorder experts. A test required to establish a diagnosis of PD with improved accuracy and reproducibility.The study aimed investigate the sensitivity specificity tests using sniffer dogs diagnose PD.A prospective, case-control was conducted in four tertiary medical centers China evaluate distinguish between 109 clinically established medicated patients PD, 654 subjects without...
Background Roux-en-Y gastric bypass (RYGB) results in extraordinary weight loss and glycemic control outcomes for patients with obesity; however, the effect of pouch size is still unclear, reported are contradictory. Additionally, long-term data on type 2 diabetes (T2D) low body mass index (BMI) sparse. This study was to assess 6-year Chinese T2D a BMI < 35 kg/m2 who underwent RYGB pouches different sizes. Methods A retrospective cohort performed. There were 42 large group (L) 53...
Background Obesity is associated with polycystic ovary syndrome (PCOS). We aimed to elucidate the research status and explore trends future directions of on obesity PCOS. Methods A bibliometric analysis published papers in field PCOS between 2012 2022 was conducted basis Web Science Core Collection database. The collaboration networks, trends, literature sources, citation analysis, co-citation keywords were statistically analyzed visualized using VOSviewer software. Results retrieved 2843...
To determine the effect of Parkinson's disease-weight bearing exercise for better balance (PD-WEBB) on impairment and falls in people with disease (PD).A single-blind, randomized controlled clinical trial was conducted. The efficacy scale score, unified Parkinson rating (UPDRS) score Mini-BESTest were measured compared between a PD-WEBB group control group.The UPDRS-2 UPDRS-3 improved (P<0.05), no significant change UPDRS-1 two groups.PD-WEBB training can significantly improve quality life...
Parkinson’s disease (PD) is a clinical syndrome and heterogeneous group of neurodegenerative conditions with variable pathologies sub-entities, characterized by motor symptoms non-motor features. PD represents an outcome the combination genes other risk or protective factors. Patients variants in phospholipase A2 VI gene (PLA2G6) can present complex Parkinsonian phenotypes. This study reported patient typical PD, including bradykinesia, gait disturbance, rigidity, rest tremor, who also...
Perihematomal edema (PHE) is a major threat leading to poor functional outcomes after intracerebral hemorrhage (ICH). TIMP-2 considered participate in the formation of PHE ICH by antagonizing damaging effects MMP-2. In early study, polymorphisms rs8179090 have shown influence expression TIMP-2.To prove that severity was different patients with genotypes.In this prospective 130 hypertensive were enrolled. The poly phisms determined. hematoma volume and measured computed tomography (CT) scan...
Abstract Background The absence of a sufficiently accurate and efficient diagnosis tuberculous meningitis (TBM) is major obstacle to delayed treatment, its non-specific clinical manifestations easily mimic the central nervous system infections caused by other causes, including virus, bacteria, cryptococcus. This study aims develop validate diagnostic score for TBM in HIV-uninfected adults simultaneously comparing with viral (VM), bacterial (BM), cryptococcal (CM). Methods Twenty-nine factors...