A5051360071- Antibiotics Pharmacokinetics and Efficacy
- Synthesis and Biological Evaluation
- Pesticide Residue Analysis and Safety
- Pharmacological Effects and Assays
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Traditional Chinese Medicine Analysis
- Microbial infections and disease research
- Drug Transport and Resistance Mechanisms
- Salmonella and Campylobacter epidemiology
- Mycotoxins in Agriculture and Food
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Veterinary medicine and infectious diseases
- Pharmacological Effects of Natural Compounds
- Insect and Pesticide Research
- Analytical chemistry methods development
- Chromatography in Natural Products
- Bioactive Compounds and Antitumor Agents
- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- Synthesis and Reactions of Organic Compounds
- Coccidia and coccidiosis research
- Ginseng Biological Effects and Applications
- Antimicrobial Resistance in Staphylococcus
- Traditional Chinese Medicine Studies
Huazhong Agricultural University
2015-2024
Guizhou University
2022-2024
Taiyuan Maternity and Child Care Hospital
2024
Hebei North University
2023
China Institute of Veterinary Drug Control
2016-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2022
Chongqing University of Posts and Telecommunications
2020
Beijing YouAn Hospital
2018
Capital Medical University
2018
China Academy of Chinese Medical Sciences
2007-2016
Deoxynivalenol (DON) and T-2 toxin commonly affect cells of the immune system cause inflammation apoptosis. Janus kinase/signal transducers activators transcription (JAK/STAT) pathway is highly associated with inflammatory process apoptosis worth investigating its role when were exposed to trichothecenes. The results showed that DON upregulated messenger RNA (mRNA) expressions interleukin (IL)-6, IL-1β, tumor necrosis factor-α, JAK1–2, STAT1–3, suppressors cytokine signaling members...
Salmonella spp. can indirectly infect humans via transfer from animals and animal-derived food products, thereby cause potentially fatal diseases. Therefore, gaining an understanding of infection in farm is increasingly important. The aim this study was to identify the distribution serotypes samples isolated chickens (n = 837), pigs 930), dairy cows 418) central China (Henan, Hubei, Hunan provinces) 2010–2011, investigate susceptibility strains antimicrobial agents. isolates were identified...
Abstract Enrofloxacin-loaded docosanoic acid solid lipid nanoparticles (SLNs) with different physicochemical properties were developed to enhance activity against intracellular Salmonella . Their cellular uptake, elimination and antibacterial studied in RAW 264.7 cells. During the experimental period, SLN-encapsulated enrofloxacin accumulated cells approximately 27.06–37.71 times more efficiently than free drugs at same extracellular concentration. After incubation for 0.5 h, was enhanced...
Antibiotics-induceds changes in intestinal flora (dysbiosis) may have various effects on the host. Dysbiosis is associated with numerous metabolites including bile acids, which are produced liver from cholesterol and metabolized gut by microbiota. Total phenolic extracts of Citrus aurantium L. (TPE-CA) rich dietary flavanones their glycosyl derivatives, flavones, flavonols, polymethoxyflavones coumarins, exert positive health The aim this study to elucidate interplays between microbiota...
Dispositions of deoxynivalenol (DON) in rats and chickens were investigated, using a radiotracer method coupled with novel γ-accurate radioisotope counting (γ-ARC) radio-high-performance liquid chromatography ion trap time-of-flight tandem mass spectrometry (radio-HPLC-IT-TOF-MS/MS) system. 3β-3H-DON was chemically synthesized orally administrated to both sexes as single or multiple doses. The results showed that DON widely distributed quickly eliminated all tissues. highest concentration...
Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) presents great challenges due to various effects steroids on multi-system pathways involved into osteoblast differentiation, and osteoclast apoptosis, lipid metabolism, calcium metabolism coagulation. As one most frequently used herbs in Traditional Chinese Medicine formulas that are prescribed for regulation bone mineral therapeutic Achyranthes bidentata steroid-induced ONFH remain unclear. Thus, aim current study was...