A5101510060- Pharmacological Effects of Natural Compounds
- Rheumatoid Arthritis Research and Therapies
- Land Use and Ecosystem Services
- Natural Compounds in Disease Treatment
- Lung Cancer Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Bone and Joint Diseases
- Hydrology and Watershed Management Studies
- Bone Metabolism and Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Angiogenesis and VEGF in Cancer
- Plant-based Medicinal Research
- Traditional Chinese Medicine Studies
- Rangeland Management and Livestock Ecology
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Conservation, Biodiversity, and Resource Management
- Climate variability and models
- Medical Imaging and Pathology Studies
- Natural product bioactivities and synthesis
- Pain Mechanisms and Treatments
- Bone health and treatments
- Hydrology and Drought Analysis
- Medicinal Plant Pharmacodynamics Research
- Cancer-related molecular mechanisms research
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Northwest Normal University
2009-2024
Dalian Municipal Central Hospital
2018-2024
Land Consolidation and Rehabilitation Center
2019-2023
Institute of Chinese Materia Medica
2019-2023
China Academy of Chinese Medical Sciences
2019-2023
Baotou Medical College
2014-2023
Huashan Hospital
2023
Fudan University
2023
Hunan Agricultural University
2020-2023
As an important means to cope with global climate change, ecological restoration projects have a huge impact on ecosystem carbon storage functions. Scientifically evaluating the response process and mechanism of basin functions in is beneficial improvement regional ecosystems. Taking Shiyang River Basin (SRB) as example, based perspective "carbon sink–carbon source" mutual transformation, current study utilized InVEST (Integrated Valuation Ecosystem Services Tradeoffs) model analyze...
Abstract Wu-tou decoction (WTD) has been extensively used for the treatment of rheumatoid arthritis (RA). Due to lack appropriate methods, pharmacological mechanisms WTD acting on RA have not fully elucidated. In this study, a list putative targets compositive compounds containing in were predicted by drugCIPHER-CS. Then, interaction network and known RA-related was constructed hub nodes identified. After constructing hubs, four topological features each hub, including degree, node...
The Shiyang River Basin is a typical arid watershed in Northwest China. Scientific understanding of the driving mechanism runoff change basis scientific utilization water resources and regional sustainable development. In this study, changes at different time scales were analyzed for period 1960–2018, impacts climate variability human activities on investigated middle lower reaches (SRB). A combination mutation analysis human-designed was adopted to divide study into baseline variation...
We previously showed that high expression levels of SOX9 correlate with hepatocellular carcinoma (HCC) progression. However, the exact role plays in HCC remains unclear. In this study, we firstly confirmed miRNA‐101 directly targets HCC. Ectopic miR‐101 significantly inhibited cell proliferation and tumorigenicity by targeting SOX9. Moreover, down‐regulation clinical tissues correlates tumor aggressiveness poor prognosis. Therefore, may suppress progression down‐regulating MiR‐101 be a...
Rheumatoid arthritis (RA) is characterized by a pre-vascular seriously inflammatory phase, followed vascular phase with high increase in vessel growth. Since angiogenesis has been considered as an essential event perpetuating and immune responses, well supporting pannus growth development of RA, inhibition proposed novel therapeutic strategy for RA. Triptolide, diterpenoid triepoxide from Tripterygium wilfordii Hook F, extensively used treatment RA patients. It also acts small molecule...
Focal bone destruction within inflamed joints is the most specific hallmark of rheumatoid arthritis (RA). Our previous study indicated that therapeutic efficiency triptolide in RA may be due partially to its chondroprotective and anti-inflammatory effects. However, roles are still unclear. In this study, our data firstly showed effects on severity progression collagen-induced (CIA) mice. Then, by micro-CT quantification, treatment significantly increased mineral density, volume fraction,...
Processing of dark tea varieties, such as Fu brick tea, Liupao Qianliang and Qing includes solid-state fermentation involving microorganisms. In this study, we analyzed the major chemical constituents extracts evaluated their modulatory effect on gastrointestinal function in normal mice, including improvement transit intestinal microbial, well attenuation microbial dysbiosis pathological damage, adjustment immune antibiotic-treated mice. Substantial differences constituents, total...
As one of the most destructive and costly natural disasters, drought has far-reaching negative effects on agriculture, water resources, environment, human life. Scientific understanding propagation from meteorological to hydrological is great significance for accurate forecasting preventing mitigating disasters. The objective this study analyze spatio-temporal variational characteristics associated driving mechanisms in eastern Qilian Mountains using standard precipitation index (SPI),...
Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) presents great challenges due to various effects steroids on multi-system pathways involved into osteoblast differentiation, and osteoclast apoptosis, lipid metabolism, calcium metabolism coagulation. As one most frequently used herbs in Traditional Chinese Medicine formulas that are prescribed for regulation bone mineral therapeutic Achyranthes bidentata steroid-induced ONFH remain unclear. Thus, aim current study was...
Bone fractures, as a global public health issue, lead to disability and reduce the quality of life for patients. Chinese patent drug Osteoking has efficacy in bone fracture therapy. However, its therapeutic properties underlying mechanisms remain unclear. In present study, rat model was established evaluate pharmacological effects by behavioral feature detection including mechanical pain threshold measurement, inclined plate hindlimb weight‑bearing test CatWalk XT gait analysis, well X‑ray...
Minor phenolic compounds in licorice (<i>Glycyrrhiza uralensis</i>) have recently been proved for diverse bioactivities and favorable bioavailability, indicating that they may play an important role the therapeutic effects or herb-drug interactions of licorice. However, so far, their abundance remains unknown. In this study, a reliable solid-phase extraction coupled with high-performance liquid chromatography diode array detection method was established to determine minor The analytes were...
The impact of the land use landscape pattern on river hydrochemistry has significant scale effects. It is premise and foundation optimization conservation water resources to accurately identify core impacting hydrochemistry. Taking Binggou River Basin in source region Shiyang as study area, this paper selected three spatial scales catchment buffer zone, riparian relationships between types indices hydrochemical characteristics were analyzed at different spatio-temporal using redundancy...