A5112374531- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Renal and related cancers
- Rheumatoid Arthritis Research and Therapies
- Pluripotent Stem Cells Research
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Natural Compounds in Disease Treatment
- Ovarian function and disorders
- Kruppel-like factors research
- Birth, Development, and Health
- Cervical and Thoracic Myelopathy
- Probiotics and Fermented Foods
- Prenatal Screening and Diagnostics
- Traditional Chinese Medicine Analysis
- Genetics, Aging, and Longevity in Model Organisms
- Reproductive Physiology in Livestock
- Microbial Inactivation Methods
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
Shenzhen Bay Laboratory
2025
Anhui Agricultural University
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Sun Yat-sen University
2024
Beijing Jiaotong University
2023
Changzhi Medical College Peace Hospital
2023
Changzhi Medical College
2023
China Academy of Chinese Medical Sciences
2022
Institute of Chinese Materia Medica
2022
Ocean University of China
2022
Abstract Background Malignant transformation from hepatic fibrosis to carcinogenesis may be a therapeutic target for hepatocellular carcinoma (HCC). The aim of this study was evaluate anti-cancer efficacy Pien-Tze-Huang (PZH), and investigate the underlying mechanisms by integrating transcriptional regulatory network analysis experimental validation. Methods A diethylnitrosamine (DEN)-induced HCC model in rats established used PZH. After detecting transcriptomic profiling, “disease-related...
Abstract N6-methyladenosine (m6A) catalyzed by METTL3 regulates the maternal-to-zygotic transition in zebrafish and mice. However, role mechanism of METTL3-mediated m6A methylation blastocyst development remains unclear. Here, we show that sustains porcine via negatively modulating autophagy. We found reduced levels triggered knockdown caused embryonic arrest during morula-blastocyst developmental defects trophectoderm cells. Intriguingly, overexpression early embryos resulted increased...
Lactiplantibacillus plantarum could regulate certain physiological functions through the AI-2/LuxS-mediated quorum sensing (QS) system. To explore regulation mechanism on growth characteristics and bacteriostatic ability of L. SS-128, a luxS mutant was constructed by two-step homologous recombination. Compared with ΔluxS/SS-128, metabolites SS-128 had stronger ability. The combined analysis transcriptomics metabolomics data showed that exhibited higher pyruvate metabolic efficiency energy...
Thousands of circular RNAs (circRNAs) have been recently discovered in cumulus cells and oocytes from several species. However, the expression function circRNA during porcine oocyte meiotic maturation never examined. Here, we separately identified 7,067 637 circRNAs both via deep sequencing bioinformatic analysis. Further analysis revealed that a faction is differentially expressed (DE) developmental stage-specific manner. The host genes DE are markedly enriched to multiple signaling...
N6-Methyladenosine (m6A) regulates oocyte-to-embryo transition and the reprogramming of somatic cells into induced pluripotent stem cells. However, role m6A methylation in porcine early embryonic development its characteristics cell nuclear transfer (SCNT) embryos are yet to be known. Here, we showed that was essential for normal aberrant SCNT embryos. We identified a persistent occurrence between 1-cell blastocyst stages levels abruptly increased during morula-to-blastocyst transition....
The establishment of a functional trophectoderm (TE) epithelium is an essential prerequisite for blastocyst formation and placentation. Transcription coactivator yes-associated protein (YAP), downstream effector the hippo signaling pathway, required specification both TE epiblast lineages in mice. However, biological role YAP porcine development not known. Here, we report that maternally derived localized to cytoplasm nuclei prior morula stage then predominantly blastocysts. Functionally,...
Zygotic genome activation (ZGA) plays an essential role in early embryonic development. Vitrification is a common assisted reproductive technology that frequently reduces the developmental competence of embryos. However, effect vitrification on porcine ZGA and gene expression during remains largely unclear. Here, we found pronuclear zygotes derived from parthenogenetic (PA) vitro fertilization (IVF) resulted significant reduction rates 2-cell, 4-cell, blastocysts, but did not affect quality...
Wandong cattle are an autochthonous Chinese breed used extensively for beef production. The tolerates extreme weather conditions and raw feed is resistant to tick-borne diseases. However, the genetic basis of testis development sperm production as well breeding management not established in local cattle. Therefore, improving reproductive efficiency bulls via selection crucial a single bull can thousands cows through artificial insemination (AI). Testis spermatogenesis regulated by hundreds...
K (lysine) acetyltransferase 8 (KAT8), an that specifically catalyzes histone H4 lysine 16 acetylation, is critical for key biological processes including cell proliferation and maintenance of genome stability. However, the role KAT8 during preimplantation development in pigs remains unclear. Results herein showed mRNA maternally derived it required successful early embryos. An abundance transcripts are expressed oocytes its continuously decreases throughout meiotic maturation development....
Abstract NESFATIN‐1 acts as a neuroendocrine hormone to suppress gonadotropin secretion in the female goldfish and prevent germinal vesicle breakdown of oocytes zebrafish. However, expression function meiotic maturation development porcine remains elusive. Genomic structure precursor nucleobindin 2 ( NUCB2 ) is first characterized detail an evolutionally closer relationship between pig rat shown by phylogenetic analysis multiple species. Additionally, immunofluorescence revealed that...
HASPIN kinase-catalyzed phosphorylation of histone H3 on threonine 3 (H3T3p) directs the activity and localization chromosomal passenger complex (CPC) spindle assembly checkpoint (SAC) to regulate chromosome condensation segregation in both mitosis meiosis. However, function kinase meiotic maturation porcine oocytes is not yet known. Here, we found that mRNA constantly expressed oocyte subsequent early embryo development. H3T3p highly enriched chromosomes at germinal vesicle breakdown (GVBD)...
The aim of this paper was to compare different effects Tripterygium Glycosides Tablets from 6 manufacturers on multiple organ injuries in rats and explore mechanism hepatotoxicity preliminarily the perspective apoptosis oxidative stress. Rats were randomly divided into groups normal, Zhejiang, Hunan, Hubei, Shanghai, Jiangsu Fujian(7 with 16 each group, sex half). given at 144 mg·kg~(-1)·d~(-1)(16 times clinical equivalent dose) once a day according its corresponding group like Zhejiang...