A5044173296- melanin and skin pigmentation
- Biochemical Analysis and Sensing Techniques
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Skin Protection and Aging
- Circular RNAs in diseases
- Reproductive Biology and Fertility
- Silk-based biomaterials and applications
- Cancer-related Molecular Pathways
- Olfactory and Sensory Function Studies
- Mast cells and histamine
- MicroRNA in disease regulation
- Renal and related cancers
- Hedgehog Signaling Pathway Studies
- Kruppel-like factors research
- Wireless Sensor Networks and IoT
- Animal Virus Infections Studies
- IoT and GPS-based Vehicle Safety Systems
- Selenium in Biological Systems
- Plant Virus Research Studies
- Regulation of Appetite and Obesity
- Genetic and phenotypic traits in livestock
- Lung Cancer Treatments and Mutations
- Vehicle License Plate Recognition
- Melanoma and MAPK Pathways
Zhejiang University
2025
Stomatology Hospital
2025
Anhui Agricultural University
2019-2024
Beijing Information Science & Technology University
2024
Shanxi Agricultural University
2015-2018
Astroglial cell diversity is essential for proper brain development and function in mammals. In mammalian cerebellum, three types of astroglial cells -Bergmann glial (BGs), inner granule layer (IGL) astrocytes, white matter (WM) astrocytes- arise postnatal timing from two progenitors: Bergmann glia-like progenitors (BGLPs) astrocyte-like (AsLPs). While BGLPs are known to differentiate into BGs IGL astrocytes day 6 (P6) mice, their fate immediately after birth remains unclear due technical...
Abstract microRNAs (miRNAs) have been shown to be closely involved in the control of melanogenesis and hair colour mammals. Previous data also indicate that miR‐143 regulates cell growth melanoma. Here, we aimed investigate role miR‐143‐5p alpaca melanocytes. We found was highly expressed cytoplasm melanocytes as demonstrated by an situ hybridization assay. Prediction analysis revealed could regulate TGF‐β‐activated kinase 1 (TAK1) expression, which confirmed luciferase reporter assay,...
Reactive oxygen species (ROS) are important factors that lead to a decline in sperm quality during semen preservation. Excessive ROS accumulation disrupts the balance of antioxidant system and causes lipid oxidative damage, destroying its structure function. Curcumin is natural plant extract neutralizes enhances function endogenous enzymes. The effect curcumin on preservation sheep has not been reported. This study aims determine effects refrigerated (4 °C) analyze metabolism from Chinese...
Thousands of circular RNAs (circRNAs) have been recently discovered in cumulus cells and oocytes from several species. However, the expression function circRNA during porcine oocyte meiotic maturation never examined. Here, we separately identified 7,067 637 circRNAs both via deep sequencing bioinformatic analysis. Further analysis revealed that a faction is differentially expressed (DE) developmental stage-specific manner. The host genes DE are markedly enriched to multiple signaling...
The molecular mechanisms underlying the formation of coat colors in animals are poorly understood. Recent studies have demonstrated that microRNA play important roles control melanogenesis and color mammals. In a previous study, we characterized miRNA expression profiles alpaca skin with brown white identified novel (named lpa-miR-nov-66) is expressed significantly higher compared to skin. present study was conducted determine functional this regulation melanocytes. lpa-miR-nov-66 predicted...
It has been demonstrated that microRNAs (miRNAs) play important roles in the control of melanogenesis and hair color mammals. By comparing miRNA expression profiles between brown white alpaca skin, we previously identified miR508-3p as a differentially expressed suggesting its potential role formation. The present study was conducted to determine melanocytes. In situ hybridization showed is abundantly cytoplasma predicted target gene encoding microphthalmia transcription factor (MITF)...
Mammalian pigmentation requires the production of melanin by melanocytes and its transfer to neighboring keratinocytes. These complex processes are regulated several molecular pathways. Melanophilin ( MLPH) WNT family member 1 WNT1), known be involved in production, respectively, were predicted targets microRNA-5110 using bioinformatics. In current study, we investigated effects on alpaca Vicugna pacos) melanocytes. situ hybridization identified high levels cytoplasm Luciferase activity...
Melanogenesis, migration and proliferation of melanocytes are important factors that determine the hair colours mammals. MicroRNAs (miRNAs) have been shown to be closely related these processes. In alpacas, insulin-like growth factor 1 (IGF1) has improve melanogenesis through cyclic AMP (cAMP) pathway. miR-379 was predicted target (IGF) receptor (IGF1R), which binds IGF1. Therefore, we hypothesized could mediate melanogenesis, melanocytes. Here, report highly expressed in alpaca Subsequent...
Porcine circovirus-like virus (PCLV) is a type of circular Rep-encoding single-stranded DNA and may be associated with the development diarrheal symptoms in pigs. In this study, we retrospectively analyzed three years past cases Anhui, China, reported case hemorrhagic enteritis death pregnant sow possibly caused by PCLV. addition, evolutionary characteristics PCLV found that mutation, recombination selective pressure all played an important role evolution We identified N15D T17S as well...
The mammalian integumentary system plays important roles in body homeostasis, and dysfunction of melanogenesis or epidermal development may lead to a variety skin diseases, including melanoma. Skin pigmentation humans coat color fleece-producing animals are regulated by many genes. Among them, microphthalmia-associated transcription factor (MITF) paired-box 3 (PAX3) at the top cascade regulate activities melanogenic enzymes. Here, we report for first time that cyclin-dependent kinase 5...
In mammals, microRNAs (miRNAs) play key roles in multiple biological processes by regulating the expression of target genes. Studies have found that levels miR-370-5p differ significantly skins sheep with different hair colors; however, its function remains unclear. this study, we investigated melanocytes and overexpression inhibited cell proliferation (P<0.01), tyrosinase activity (P=0.001) reduced (P<0.001) melanin production. Functional prediction revealed 3´-untranslated region (UTR)...
Melanoma is a highly invasive and metastatic malignant skin tumor with poor prognosis. Although several widely studied pure melanoma cell lines are available, the precise mechanism underlying transformation of melanocyte to remains unclear. Long non-coding RNAs (lncRNAs) represent vast category RNA molecules, increasing evidence suggests that lncRNAs crucial for various biological processes, including those in skin. Herein, lncRNA sequencing was performed on an Illumina HiSeq platform...
Long noncoding RNAs (lncRNAs) are involved in many biological processes and have been extensively researched. Nonetheless, literature focusing on the roles of lncRNA melanocytes is limited. Melanocytes located basal layer epidermis determine color an animal's skin hair by producing melanin. The mechanisms melanogenesis remain unclear. Here, from Boer goat skins were successfully isolated verified using morphological observation, dopamine staining, silver ammonia immunohistochemical staining...
Skin and hair pigmentation in animals involve intricate regulatory processes. Circular RNA-microRNA (circRNA-miRNA) networks play vital roles various biological processes, although their involvement has been underexplored. This study focused on circKIF27 expression, which differs significantly melanocytes isolated from white brown Boer coat-colored skin, yet its function remains unclear. Here, we investigated the of melanocytes. In situ hybridization assays demonstrated that is expressed...