A5102840095- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Anesthesia and Pain Management
- Biochemical Analysis and Sensing Techniques
- Neurobiology and Insect Physiology Research
- Geological Studies and Exploration
- Neuroendocrine regulation and behavior
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neuropharmacology Research
- AI in Service Interactions
- Methane Hydrates and Related Phenomena
- Ion channel regulation and function
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Nitric Oxide and Endothelin Effects
- Aquaculture disease management and microbiota
- Spine and Intervertebral Disc Pathology
- Biochemical effects in animals
- Apelin-related biomedical research
- Transcranial Magnetic Stimulation Studies
- Cardiac tumors and thrombi
- Wastewater Treatment and Nitrogen Removal
- Education, Achievement, and Giftedness
- Chromium effects and bioremediation
Southwest University
2016-2024
Kunming Institute of Zoology
2022
University of Hong Kong
2022
AstraZeneca (Sweden)
2009-2022
Nanjing Agricultural University
2022
Shanghai University
2020
Anhui Agricultural University
2016-2019
State Administration of Traditional Chinese Medicine of the People's Republic of China
2015
Shanghai Ocean University
2014
Shandong Agricultural University
2013
Abstract Nesfatin-1 is an important molecule in the regulation of reproduction. However, its role reproductive axis male animals remains to be understood. Here, we found that nesfatin-1 was mainly distributed arcuate nucleus (ARC), paraventricular (PVN), periventricular (PeN), and lateral hypothalamic area (LHA) hypothalamus; adenohypophysis Leydig cells rats. Moreover, concentrations serum mRNA hypothalamo-pituitary-gonadal (HPGA) vary with age rat. After intracerebroventricular injection...
Heat stress-induced reduction in feed intake is an annoyance of the poultry industry. Feed regulated by complex mechanisms which brain-gut neuropeptides are involved, but changes such broiler chickens during heat exposure remain unclear. In this study, we investigated effects acute stress (35°C, 6 h, and 65% relative humidity) on gene expression appetite-regulating peptides hypothalamus gastrointestinal tract at 42 d age. The hypothalamic mRNA levels neuropeptide Y, agouti-related peptide,...
The most widely used formalin test to screen antinociceptive drug candidates is still apostrophized as targeting inflammatory pain, in spite of strong opposing evidence published. In our rat skin-nerve preparation ex vivo, recording from all classes sensory single-fibers (n = 32), 30 units were transiently excited by formaldehyde concentrations 1-100 mM applied receptive fields (RFs) for 3 min, C and Aδ-fibers being more sensitive (1-30 mM) than Aβ-fibers. From on, ~1% the concentration...
Sherman, Stephen E., Lei Luo, and Jonathan O. Dostrovsky. Spinal strychnine alters response properties of nociceptive-specific neurons in rat medial thalamus. J. Neurophysiol. 78: 628–637, 1997. Experiments both conscious anesthetized animals indicate that intrathecal (i.t.) (STR; glycine receptor antagonist) produces acute, reversible allodynia, as evidenced by inappropriate behavioral autonomic responses to cutaneous tactile stimuli. Although STR is known produce disinhibition afferent...
We have previously shown that intrathecal (i.t.) morphine, but not the alpha 2-adrenoreceptor agonist clonidine, administered prior to sciatic nerve section, reduced level of autotomy in rats, which is a behavioural model neuropathic pain. Neither drug was effective when 15 min after section. now examined effects i.t. morphine and clonidine on development flexor reflex hyperexcitability following section acute physiological experiments. The recorded from hamstring muscles decerebrate,...
Sherman, Stephen E., Lei Luo, and Jonathan O. Dostrovsky. Altered receptive fields sensory modalities of rat VPL thalamic neurons during spinal strychnine-induced allodynia. J. Neurophysiol. 78: 2296–2308, 1997. Allodynia is an unpleasant sequela neural injury or neuropathy that characterized by the inappropriate perception light tactile stimuli as pain. This condition may be modeled experimentally in animals intrathecal (i.t.) administration strychnine, a glycine receptor antagonist. Thus...
Pain is the most common presenting physical symptom and a primary reason for seeking medical care, which chronically affects people's mental health social life. CaV3.2 channel plays an essential role in peripheral processing maintenance of pain states. This study was designed to identify novel drug candidates targeting channel. Whole-cell patch-clamp, cellular thermal shift assay, FlexStation, vivo vitro knock-down, site-directed mutagenesis, double-mutant cycle analysis were employed...
Abstract Physical stressors play a crucial role in the progression of irritable bowel syndrome (IBS). Here we report heterogeneous physical stress induced IBS rat model which shows depression and subsequent modulation by oral treatment thymol. Oral administration Thymol reduces significantly altering gastrointestinal hypermotility, prolonged whole gut transit time, increased abdominal withdrawal reflex suggesting hypermotility visceral discomfort caused onset depression. Immunohistochemical...
The effect of 500 micrograms intrathecal (i.t.) lidocaine and tocainide injected prior to unilateral sciatic nerve section on the development autotomy behavior was examined in rats. Neither drug inhibited compared with saline controls. flexor reflex decerebrate, spinalized rats also examined. Both drugs at i.t. totally blocked hyperexcitability following acute section, a longer duration action tocainide. Recovery from followed by prolonged period hyperexcitability, even without axotomy....
Abstract Several studies have demonstrated that the neuropeptide peptide YY (PYY) plays an important role in feeding mammals and fish. However, thus far, regulation function of PYY Schizothorax davidi has not been well understood. Here, we identified full‐length cDNA sequence S. for first time. contains 803 bp nucleotides including a 328 3′ untranslated region (UTR), 181 5′ UTR, 294 open reading frame encoding 97 amino acids. expression was observed almost all tissues, with highest detected...