A5013648181- Antimicrobial Peptides and Activities
- Venomous Animal Envenomation and Studies
- Ion channel regulation and function
- Blood Coagulation and Thrombosis Mechanisms
- Healthcare and Venom Research
- Probiotics and Fermented Foods
- Biochemical and Structural Characterization
- Gut microbiota and health
- Insect and Pesticide Research
- Phagocytosis and Immune Regulation
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Mosquito-borne diseases and control
- Marine Invertebrate Physiology and Ecology
- Acute Ischemic Stroke Management
- Fungal Infections and Studies
- Leech Biology and Applications
- Rabies epidemiology and control
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Alzheimer's disease research and treatments
- Veterinary Pharmacology and Anesthesia
- Antimicrobial agents and applications
- Otolaryngology and Infectious Diseases
Chinese Academy of Sciences
2018-2025
University of Hong Kong
2020-2025
University of Chinese Academy of Sciences
2018-2025
Kunming Institute of Zoology
2018-2025
Emory University
2024
Chinese University of Hong Kong
2022-2024
Hefei National Center for Physical Sciences at Nanoscale
2020
University of Science and Technology of China
2020
Chongqing Public Health Medical Center
2020
Southwest University
2020
The emergence of carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa raises fears untreatable infections poses the greatest health threats. Antimicrobial peptides (AMPs) are regarded as most ideal solution to this menace. In study, a set was designed based on our previously reported peptide cathelicidin-BF-15, lead ZY4, cyclic stabilized by disulfide bridge with high stability in vivo (the half-life is 1.8 h), showed excellent activity against P. A. baumannii, including...
Rationale: Epidemiological studies have identified an associate between iron deficiency (ID) and the use of oral contraceptives (CC) ischemic stroke (IS). To date, however, underlying mechanism remains poorly understood. Both ID CC been demonstrated to upregulate level iron-binding ability Tf (transferrin), with our recent study showing that this upregulation can induce hypercoagulability by potentiating FXIIa/thrombin blocking antithrombin-coagulation proteases interactions. Objective:...
Studies have shown significantly increased thromboembolic events at high altitude. We recently reported that transferrin could potentiate blood coagulation, but the underlying mechanism for altitude-related thromboembolism is still poorly understood. Here, we examined activity and concentration of plasma coagulation factors in collected from long-term human residents short-stay mice exposed to varying altitudes. found activities thrombin factor XIIa (FXIIa) along with concentrations were...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been detected in almost all organs of disease-19 patients, although some do not express angiotensin-converting enzyme-2 (ACE2), a known receptor SARS-CoV-2, implying the presence alternative receptors and/or co-receptors. Here, we show that ubiquitously distributed human transferrin (TfR), which binds to diferric traffic between membrane and endosome for iron delivery cycle, can ACE2-independently mediate SARS-CoV-2...
Abstract Coagulation balance is maintained through fine-tuned interactions among clotting factors, whose physiological concentrations vary substantially. In particular, the of coagulation proteases (pM to nM) are much lower than their natural inactivator antithrombin (AT, ~ 3 μM), suggesting existence other coordinators. current study, we found that transferrin (normal plasma concentration ~40 μM) interacts with fibrinogen, thrombin, factor XIIa (FXIIa), and AT different affinity maintain...
The voluntary carbon market needs to embrace changes for the land sector.
Antibiotic resistance is a global threat. Antimicrobial peptides (AMPs) are highly desirable to treat multidrug-resistant pathogen infection. However, few AMPs clinically available, due high cost, instability, and poor selectivity. Here, ultrashort (2–3 residues with an N-terminal cysteine) designed assembled as gold nanoparticles. Au–S conjugation size restrict nonspecific reactions peptide orientation, thus concentrating positively charged on the surface. The nanostructured assemblies...
Antimalarial drug resistance is an enormous global threat. Recently, antimicrobial peptides (AMPs) are emerging as a new source of antimalarials. In this study, AMP LZ1 derived from snake cathelicidin was identified with antimalarial activity. the in vitro antiplasmodial assay, showed strong suppression blood stage Plasmodium falciparum (P. falciparum) IC50 value 3.045 μM. vivo exerted significant activity against berghei berghei) dose- and time- dependent manner. addition, exhibited...
Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer have a higher dependency on molecular chaperones maintain proteostasis. The chaperonin T-complex protein ring complex (TRiC) contains eight paralogous subunits (CCT1-8), and assists folding as many 10% cytosolic proteome. TRiC essential for progression some cancers, but roles osteosarcoma remain be explored. Here, we show that CCT4/TRiC...
Flaviviruses are single-stranded RNA viruses predominantly transmitted by the widely distributed Aedes mosquitoes in nature. As important human pathogens, geographic reach of and their threats to public health increasing, but there is currently no approved specific drug for treatment. In recent years, development peptide antivirals has gained much attention. Natural host defense peptides which uniquely evolved protect hosts have been shown antiviral properties. this study, we firstly...
Zika virus (ZIKV) is a mosquito-borne belonging to the genus Flavivirus and has reemerged in recent years with epidemic potential. ZIKV infection may results severe syndromes such as neurological complications microcephaly newborns. Therefore, become global public health threat currently there no approved specific drug for its treatment. Animal venoms are important resources of novel drugs. Cathelicidin-BF (BF-30) defensive peptide identified from Bungarus fasciatus snake venom been shown be...
Cross-talks (e.g., host-driven iron withdrawal and microbial uptake between host gastrointestinal tract commensal microbes) regulate immunotolerance intestinal homeostasis. However, underlying mechanisms that the cross-talks remain poorly understood. Here, we show bacterial products up-regulate iron-transporter transferrin acts as an immunosuppressor by interacting with cluster of differentiation 14 (CD14) to inhibit pattern recognition receptor (PRR) signaling induce immunotolerance....
Antistasin, first identified as a potent inhibitor of the blood coagulation factor Xa, is novel family serine protease inhibitors. In this study, we purified antistasin-type from leech Poecilobdella manillensis called poecistasin. Amino acid sequencing 48-amino-acid protein revealed that poecistasin was an known to consist only one domain. Poecistasin inhibited XIIa, kallikrein, trypsin, and elastase, but had no inhibitory effect on Xa thrombin. showed anticoagulant activities. It prolonged...
Snake venoms contain components selected to immobilize prey. The from Elapidae mainly neurotoxins, which are critical for rapid prey paralysis, while the Viperidae and Colubridae may fewer neurotoxins but likely induce circulatory disorders. Here, we show that Protobothrops mucrosquamatus Trimeresurus stejnegeri comparable those of Naja atra in immobilization. Further studies indicate snake C-type lectin-like proteins (snaclecs), one main nonenzymatic viper venoms, responsible Snaclecs...
Abstract Bleeding and thrombocytopenia to readministration are the most serious side effects of clinical integrin αIIbβ3 antagonists such as RGD-containing peptides. Here we show that a non-RGD peptide ZDPI, identified from skin secretions Amolops loloensis, inhibited platelet aggregation induced by agonists, adenosine diphosphate, collagen, arachidonic acid, PAR1AP, allosteric activator, reduces soluble fibrinogen binding activated platelets without perturbing adhesion numbers on...
It was recently discovered that Ssm Spooky Toxin (SsTx) with 53 residues serves as a key killer factor in red-headed centipede's venom arsenal, due to its potent blockage of the widely expressed KCNQ channels simultaneously and efficiently disrupt cardiovascular, respiratory, muscular, nervous systems, suggesting SsTx is basic compound for centipedes' defense predation. Here, we show also inhibits KV1.3 channel, which would amplify broad-spectrum disruptive effect blocking KV7 channels....
Cryptococcus neoformans (C. neoformans) is a pathogenic fungus that can cause life-threatening meningitis, particularly in individuals with compromised immune systems. The current standard treatment involves the combination of amphotericin B and azole drugs, but this regimen often leads to inevitable toxicity patients. Therefore, there an urgent need develop new antifungal drugs improved safety profiles. We screened antimicrobial peptides from hemolymph transcriptome Blaps rhynchopetera (B....