A5048060417- Hydrocarbon exploration and reservoir analysis
- Petroleum Processing and Analysis
- Atmospheric and Environmental Gas Dynamics
- COVID-19 Clinical Research Studies
- Methane Hydrates and Related Phenomena
- Phagocytosis and Immune Regulation
- Glioma Diagnosis and Treatment
- Enhanced Oil Recovery Techniques
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Hydraulic Fracturing and Reservoir Analysis
- Neurological Disease Mechanisms and Treatments
- Esophageal Cancer Research and Treatment
- Neurological Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Geochemistry and Elemental Analysis
- Geochemistry and Geologic Mapping
- Virus-based gene therapy research
- Intensive Care Unit Cognitive Disorders
- Rock Mechanics and Modeling
- Cerebrospinal fluid and hydrocephalus
- Paleontology and Stratigraphy of Fossils
- Seismic Imaging and Inversion Techniques
- Lung Cancer Diagnosis and Treatment
- Geological and Geophysical Studies
Beijing Tian Tan Hospital
2019-2025
Capital Medical University
2019-2025
Hunan Institute of Science and Technology
2025
China Agricultural University
2024-2025
Chenzhou First People's Hospital
2024-2025
University of South China
2024-2025
Kunming Institute of Zoology
2020-2024
Chinese Academy of Sciences
2014-2024
University of Chinese Academy of Sciences
2020-2024
Chinese University of Hong Kong
2022-2024
The urine of febrile patients has been found to contain high concentrations an inhibitor interleukin 1 (IL-1)-induced thymocyte proliferation. is specific for IL-1 and does not block the effects 2 (IL-2) or phytohemagglutin (PHA) on thymocytes, it nonspecifically toxic these cells. can be in normal individuals afebrile patients, but present increased with fever diverse etiologies. Preliminary physicochemical characterization indicates that a 20-40-kdalton protein.
Studies have shown significantly increased thromboembolic events at high altitude. We recently reported that transferrin could potentiate blood coagulation, but the underlying mechanism for altitude-related thromboembolism is still poorly understood. Here, we examined activity and concentration of plasma coagulation factors in collected from long-term human residents short-stay mice exposed to varying altitudes. found activities thrombin factor XIIa (FXIIa) along with concentrations were...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been detected in almost all organs of disease-19 patients, although some do not express angiotensin-converting enzyme-2 (ACE2), a known receptor SARS-CoV-2, implying the presence alternative receptors and/or co-receptors. Here, we show that ubiquitously distributed human transferrin (TfR), which binds to diferric traffic between membrane and endosome for iron delivery cycle, can ACE2-independently mediate SARS-CoV-2...
Abstract Lumpy skin disease virus (LSDV) is a poxvirus that mainly affects cattle and can lead to symptoms such as severe reduction in milk production well infertility mortality, which has resulted dramatic economic loss affected countries Africa, Europe, Asia. In this study, we successfully isolated two strains of LSDV from different geographical regions China. Comparative genomic analyses were performed by incorporating additional whole genome sequences reported other areas Our revealed...
Abstract Angiotensin-converting enzyme 2 (ACE2) has been suggested as a receptor for severe acute respiratory syndrome coronavirus (SARS-CoV-2) entry to cause disease 2019 (COVID-19). However, no ACE2 inhibitors have shown definite beneficiaries COVID-19 patients, applying the presence of another SARS-CoV-2 entry. Here we show that knockout dose not completely block virus entry, while TfR directly interacts with Spike protein mediate and can infect mice over-expressed humanized transferrin...
The high-temperature proton exchange membranes suffer from weak binding strength for phosphoric acid molecules, which seriously reduce the fuel cell efficiency, especially operation stability. Introduction of microporous material in membrane can effectively leaching acid. However, due to poor compatibility between polymer and fillers, membrane's performance significantly reduced at high fillers content. Therefore, this work, strategy micropore confinement was developed; β-cyclodextrin...
Stroke is the second leading cause of death globally. Oxidative stress plays a critical role in development stroke. The Balance Score (OBS) tool used to assess combined impact diet and lifestyle on body's antioxidant capacity. study included stroke survivors from National Health Nutrition Examination Survey (1999-2018), with total 1,781 participants median follow-up duration 6.5 years, during which 786 (39.59%) died. relationship between OBS all-cause mortality was assessed using Cox...
Poxviruses are large DNA viruses with an arsenal of immune-modulatory genes, many which remain uncharacterized. Proteins ankyrin repeats distinct features poxviruses, although the biological functions proteins not fully understood. Lumpy skin disease virus (LSDV) encodes five repeats. Here, we reveal role LSDV012, protein, in conferring resistance to type I interferon (IFN) cells. Deletion LSDV012 from LSDV significantly impacted viral replication presence IFN, highlighting importance...
Pulmonary eosinophilic granuloma is a disorder caused by localized collections of proliferating histiocytes in the lung. Little known about its etiology except that majority (58 to 97%) patients are current or ex-smokers, making potential etiologic role tobacco products an important area for research. Tobacco glycoprotein (TGP) potent immunostimulator has been isolated from cigarette smoke. TGP-specific lymphocyte proliferation, and cytokine production vitro, were measured three with...
Cross-talks (e.g., host-driven iron withdrawal and microbial uptake between host gastrointestinal tract commensal microbes) regulate immunotolerance intestinal homeostasis. However, underlying mechanisms that the cross-talks remain poorly understood. Here, we show bacterial products up-regulate iron-transporter transferrin acts as an immunosuppressor by interacting with cluster of differentiation 14 (CD14) to inhibit pattern recognition receptor (PRR) signaling induce immunotolerance....
The occurrence and distributions of aliphatic biomarkers in oil contaminated soils from Owaza, Niger Delta, Nigeria, were investigated by gas chromatography-mass spectrometry (GC-MS). concentrations the n-alkanes Σ(nC14 to nC29) ranged 18,680.4 35,615.8 μg/g (average 24,664.0 μg/g). abundance extracts show that effect environmental degradation on impacted has been minimal. N-alkanes diagnostic indices, source maturity parameters computed for terpanes steranes indicate Delta as contamination....
Abstract Angiotensin-converting enzyme 2 (ACE2) has been suggested as a receptor for severe acute respiratory syndrome coronavirus (SARS-CoV-2) entry to cause disease 2019 (COVID-19). However, no ACE2 inhibitors have shown definite beneficiaries COVID-19 patients, applying the presence of another SARS-CoV-2 entry. Here we show that knockout dose not completely block virus entry, while TfR directly interacts with Spike protein mediate and can infect mice over-expressed humanized transferrin...
Abstract Background Poliovirus receptor interacts with 3 receptors: T-cell immunoglobulin immunoreceptor tyrosine-based inhibitory motif, CD96, and DNAX accessory molecule 1, which are predominantly expressed on T cells natural killer (NK) cells. Many solid tumors, including IDH wild-type glioblastoma, have been reported to overexpress poliovirus receptor, this overexpression is associated poor prognosis. However, there no preclinical or clinical trials investigating the use of cell-based...
Abstract Background: Acute liver failure (ALF) is a disease of acute derangements in the hepatic synthetic function with defects involving innate immune responses, which was reported to be negatively regulated by tumor necrosis factor α-induced protein 3 (A20). Herein, present study conducted investigate effects A20 on proliferation and apoptosis hepatocytes through nuclear (NF)-κB signaling pathway rat models simulating ALF. Methods: Male Wistar rats were used simulate ALF model rats. Next,...
SignificanceAn immunosuppressant protein (MTX), which facilitates virus infection by inhibiting leukotriene A4 hydrolase (LTA4H) to produce the lipid chemoattractant B4 (LTB4), was identified and characterized from submandibular salivary glands of bat Myotis pilosus. To best our knowledge, this is a report an endogenous LTA4H inhibitor in animals. MTX highly concentrated glands, suggesting mechanism for generation immunological privilege immune tolerance providing evidence viral shedding...