A5100734879- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Glioma Diagnosis and Treatment
- Chromosomal and Genetic Variations
- Brain Metastases and Treatment
- Aortic aneurysm repair treatments
- Ferroptosis and cancer prognosis
- Genetic Syndromes and Imprinting
- Aortic Disease and Treatment Approaches
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Meningioma and schwannoma management
- Congenital heart defects research
- Reconstructive Surgery and Microvascular Techniques
- Intracranial Aneurysms: Treatment and Complications
- Congenital Anomalies and Fetal Surgery
- Cancer-related Molecular Pathways
- Cancer-related cognitive impairment studies
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Reconstructive Facial Surgery Techniques
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Biochemical and Structural Characterization
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Guangzhou University of Chinese Medicine
2011-2025
Peking Union Medical College Hospital
2015-2025
Mackay Memorial Hospital
2013-2024
Beijing University of Chinese Medicine
2020-2024
Peking University
2024
Kunming Medical University
2011-2024
Peking University Cancer Hospital
2024
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Glioblastoma (GBM), the most lethal primary brain malignancy, is divided into histological (hist-GBM) and molecular (mol-GBM) subtypes according to 2021 World Health Organization classification of central nervous system tumors. This study aimed characterize clinical, radiological, molecular, survival features GBM under current scheme explore determinants.We re-examined genetic alterations IDH-wildtype diffuse gliomas at our institute from 2011 2022, enrolled GBMs for analysis after...
The optimal treatment of recurrent glioblastoma (GBM) remains controversial. Therefore, our study aimed to compare and rank active therapies in GBM. We performed a systematic review Bayesian network meta-analysis. obtained hierarchy using the surface under cumulative ranking curve mean ranks. A cluster analysis was conducted aggregate separated results three outcomes. protocol registered PROSPERO (CRD42019146794). total 1,667 citations were identified, 15 eligible articles with 17 treatments...
Background The 5th edition of the World Health Organization (WHO) classification central nervous system tumors incorporated specific molecular alterations into categorization gliomas. major revision scheme effectuates significant changes in diagnosis and management glioma. This study aimed to depict clinical, molecular, prognostic characteristics glioma its subtypes according current WHO classification. Methods Patients who underwent surgery for at Peking Union Medical College Hospital...
The differential diagnosis of primary central nervous system lymphoma from glioblastoma multiforme (GBM) is essential due to the difference in treatment strategies. This study retrospectively reviewed 77 patients (24 with and 53 GBM) identify stable distinguishable characteristics GBM 18F-fluorodeocxyglucose (FDG) positron emission tomography (PET) images using a radiomics approach. Three groups maps, namely, standardized uptake value (SUV) map, an SUV map calibrated normal contralateral...
The 2021 WHO Classification of Central Nervous System Tumors introduces more molecular markers for glioma reclassification, including TERT promoter (TERTp) mutation as a key feature in glioblastoma diagnosis. Given the changes entities included each subtype under new classification, this research investigated distribution, prognostic value, and correlations with other alterations TERTp different subgroups latest classification. All patients admitted to Peking Union Medical College Hospital...
Prognostic risk factors were analyzed for patients with acute anterior circulation large-vessel occlusion stroke who achieved Modified Treatment in Cerebral Ischemia (mTICI) 3 grade by endovascular treatment. Acute ischemic (AIS) mTICI=3 after treatment from June 2019 to September 2024 at the Eighth Clinical College of Guangzhou University Traditional Chinese Medicine retrospectively analyzed. Data related patients' baseline data, factors, test and surgical data collected, primary endpoint...
Renal ischemia-reperfusion injury (IRI) is a major cause of acute renal failure. Our previous studies have shown that pioglitazone, peroxisome proliferators-activated receptor (PPAR)-γ agonist used in type 2 diabetes, protects against IRI; however, the molecular mechanism underlying renoprotective effects pioglitazone still unclear. In this study, we investigated role AMP-activated protein kinase (AMPK)-regulated autophagy renoprotection by IRI. To investigate whether cells from IRI, an vivo...
Background The 2021 World Health Organization Classification of Central Nervous System Tumors updates glioma subtyping and grading system, incorporates EGFR amplification (Amp) as one diagnostic markers for glioblastoma (GBM). Purpose This study aimed to describe the frequency, clinical value molecular correlation Amp in diffuse gliomas based on latest classification. Methods We reviewed patients between 2011 2022 at our hospital, included 187 adult with available tumor tissue detection...
The psychological traits of cosmetic surgery patients (CSP) are important for selecting and postoperative patient satisfaction. A patient's self-esteem, self-efficacy, self-assessment affect his or her motivation surgery, but the association among these remains unclear, especially in Asian population. To clarify a traits, decision to undergo effectiveness facial on conditions young, female Chinese patients. Three different groups young women (aged 18-30 years) from Plastic Surgery Hospital,...
Abstract Reprogramming of vascular smooth muscle cell (VSMC) differentiation plays an essential role in abdominal aortic aneurysm (AAA). However, the underlying mechanisms are still unclear. We explore expression FAM3A, a newly identified metabolic cytokine, and whether how FAM3A regulates VSMC AAA. discover that is decreased aortas plasma AAA patients murine models. Overexpression or supplementation significantly attenuate formation, manifested by maintenance well-differentiated status...
Abstract Myxofibrosarcoma (MFS) is a malignant fibroblastic/myofibroblastic neoplasm with prominent myxoid area. It has the clinical features of frequent local recurrence (LR) and occasional distant metastasis. Robust epidemiological data on MFS in China are lacking. The aim this retrospective analysis was to determine natural history MFS, identify prognostic factors for describe real-life outcomes MFS. We reviewed 52 patients primary from First Affiliated Hospital Nanjing Medical University...
We present mosaic distal 10q deletion at prenatal diagnosis in a pregnancy associated with favorable fetal outcome. A 40-year-old, gravida 2, para 0, woman underwent amniocentesis 16 weeks of gestation because advanced maternal age. Amniocentesis revealed karyotype 46,XY, del(10) (q26.13)[6]/46,XY[17]. Simultaneous array comparative genomic hybridization (aCGH) analysis on the DNA extracted from uncultured amniocytes showed 35% mosaicism for 10q26.13q26.3 deletion. At 22 gestation, she...
Cathelicidins, a major class of antimicrobial peptides (AMPs), hold considerable potential for drug development. In the present study, we identified novel cathelicidin AMP (TC-33) derived from Chinese tree shrew. Despite TC-33 demonstrating weak activity, peptide TC-14, developed based on its active region, exhibited 432-fold increase in activity over parent peptide. Structural analysis revealed that TC-14 adopted an amphipathic α-helical conformation. The bactericidal mechanism involved...
The E3 ubiquitin ligase RING finger protein 115 (RNF115), also known as breast cancer-associated gene 2 (BCA2), has previously been reported to be overexpressed in estrogen receptor α (ERα)-positive tumors and promote cell proliferation; however, its mechanism is unknown. In this study, we demonstrated that silencing of BCA2 by small interfering RNAs (siRNAs) two ERα-positive cancer lines, MCF-7 T47D, decreases proliferation increases the levels cyclin-dependent kinase inhibitor p21Waf/Cip1....
Gliomas are infiltrative neoplasms with a highly invasive nature. Due to its distinct genomic, genetic and epigenetic features, the immune prognostic signature (IPS) microenvironment of glioblastoma (GBM) merit further research. We aimed explore prognosis-related genes develop an IPS model for predicting prognosis in GBM. RNA-sequencing data, as well clinical information, from The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) public cohorts were analyzed. To IPS, least absolute shrinkage...
Glioblastoma (GBM) is the most common primary malignant intracranial tumor with a poor prognosis. Ferroptosis newly discovered, iron-dependent, regulated cell death, and recent studies suggest its close correlation to GBM. The transcriptome clinical data were obtained for patients diagnosed GBM from TCGA, GEO, CGGA. Ferroptosis-related genes identified, risk score model was constructed using Lasso regression analyses. Survival evaluated by univariate or multivariate Cox regressions...