A5100677627- Gyrotron and Vacuum Electronics Research
- Advanced Proteomics Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Aortic aneurysm repair treatments
- Particle accelerators and beam dynamics
- Mass Spectrometry Techniques and Applications
- Pulsed Power Technology Applications
- Microbial Community Ecology and Physiology
- Gut microbiota and health
- Extracellular vesicles in disease
- Aortic Disease and Treatment Approaches
- Peptidase Inhibition and Analysis
- Marine and coastal ecosystems
- Soil Carbon and Nitrogen Dynamics
- Thyroid Cancer Diagnosis and Treatment
- Carbon Nanotubes in Composites
- Infectious Aortic and Vascular Conditions
- Particle Accelerators and Free-Electron Lasers
- Glycosylation and Glycoproteins Research
- Molecular Biology Techniques and Applications
- Microwave Engineering and Waveguides
- Marine Biology and Ecology Research
- Isotope Analysis in Ecology
- Geology and Paleoclimatology Research
- Electromagnetic Simulation and Numerical Methods
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2019-2025
China Geological Survey
2020-2025
Ministry of Natural Resources
2020-2025
Capital Institute of Pediatrics
2024
National Clinical Research
2024
Academy of Medical Sciences
2024
Jiangsu Provincial Institute of Geological Survey
2006-2024
Qingdao University of Science and Technology
2024
Deyang Stomatological Hospital
2024
Abstract Background Brain metastasis (BM) is the most common intracranial malignancy causing significant mortality, and lung cancer origin of BM. However, cellular origins drivers BM from adenocarcinoma (LUAD) have yet to be defined. Methods The constitutions were characterized by single-cell transcriptomic profiles 11 LUAD primary tumor (PT) 10 samples (GSE131907). Copy number variation (CNV) clonality analysis applied illustrate tumors. metastasis-associated epithelial cells (BMAECs)...
Gigahertz to terahertz radiation sources based on cold-cathode vacuum electron technology are pursued, because its unique characteristics of instant switch-on and power saving important military space applications. gyrotron was reported using carbon nanotube (CNT) cold-cathode. It is here in first time that a fully-sealed CNT 0.22 THz-gyrotron realized, typically with output 500 mW. To achieve this, we have studied mechanisms responsible for CNTs growth curved shape metal surface, field...
Abstract Despite advances in cancer treatments, early diagnosis of is still the most promising way to improve outcomes. Without homeostatic control, urine reflects systemic changes body and can potentially be used for detection cancer. In this study, a tumor‐bearing rat model was established by subcutaneous injection Walker 256 cells. Urine samples from rats were collected at five time points during development. Dynamic proteomes profiled using liquid chromatography coupled with tandem mass...
Soil microorganisms play an important role in agricultural ecosystems, but their response to organic fertilizer application has not been thoroughly elucidated. Thus, high-throughput sequencing was used investigate the responses of soil bacterial amendment (composted from pig manure) field during entire growth cycle maize plants. Four treatments were studied: treatment with 2 kg·m−2 (OF_2), 4 (OF_4), 6 (OF_6), and a controlled (CK) without fertilization. The results revealed that richness...
Abstract Urine has the potential to become a better source of biomarkers. Urinary proteins are affected by many factors; therefore, differentiating between variables associated with any particular pathophysiological condition in clinical samples is challenging. To circumvent these problems, simpler systems, such as animal models, should be used establish direct relationship disease progression and urine changes. In this study, unilateral ureteral obstruction (UUO) model was observe tubular...
Sea surface temperature (SST) is a key parameter in ocean hydrology. Currently, existing SST prediction methods fail to fully utilize the potential spatial correlation between variables. To address this challenge, we propose spatiotenporal UNet (ST-UNet) model based on model. In particular, encoding phase of ST-UNet, use parallel convolution with different kernel sizes efficiently extract features, and ConvLSTM capture temporal features utilization features. Atrous Spatial Pyramid Pooling...
Abstract Urinary proteomics is emerging as a potent tool for detecting sensitive and non-invasive biomarkers. At present, the comparability of urinary data across diverse liquid chromatography−mass spectrometry (LC-MS) platforms remains an area that requires investigation. In this study, we conduct comprehensive evaluation proteome multiple LC-MS platforms. To systematically analyze assess quality large-scale data, develop control (QC) system named MSCohort, which extracted 81 metrics...
The combination of Janus kinase (JAK) inhibitors and narrow-band ultraviolet B (NB-UVB) therapy is an effective treatment for vitiligo; however, reliable convenient biomarkers predicting efficacy prior to are currently lacking. biomarker pre-treatment plasma C-C motif chemokine ligand 5 fibrinogen-like protein 1 levels, along with urine ezrin glyceraldehyde 3-phosphate dehydrogenase can predict the sensitivity baricitinib combined NB-UVB in patients vitiligo.
The Shitangwan earth fissure is a resultant geological hazard due to prolonged groundwater depletion and land subsidence in Wuxi, China, since the 1980s. Initially observed 1991, experienced continuous development over next several decades. Employing diverse array of techniques, including field monitoring via multilayered borehole extensometers, for lateral vertical movements, advanced geophysical exploration, conventional investigations, this study aims mitigate risks associated with...
Pulmonary fibrosis (PF) is a progressive and devastating lung disease. With limited effective treatments available in the late stage, PF has very poor prognosis. Molecular biomarkers are highly desired for PF, especially its early phase.Urine good biomarker source, accumulates systemic changes body early-stage of diseases. In this study, bleomycin (BLM)-induced rat model used to mimic PF. Using labeled proteome quantitation, some urinary proteins identified as candidate detection disease...
Abstract Reprogramming of vascular smooth muscle cell (VSMC) differentiation plays an essential role in abdominal aortic aneurysm (AAA). However, the underlying mechanisms are still unclear. We explore expression FAM3A, a newly identified metabolic cytokine, and whether how FAM3A regulates VSMC AAA. discover that is decreased aortas plasma AAA patients murine models. Overexpression or supplementation significantly attenuate formation, manifested by maintenance well-differentiated status...
Objective To determine the short-term effectiveness safety of baricitinib in children with refractory and/or severe juvenile dermatomyositis (rsJDM) a real-world setting. Methods This was single-center retrospective study, including 20 rsJDM. They were all treated using combined steroids and other immunosuppressive agents. The childhood myositis assessment scale (CMAS) PRINTO remission criteria used to evaluate disease severity treatment outcome at 0, 4, 12, 24 weeks after initiation...
Groundwater provides freshwater resources necessary for mankind, but its quality is significantly impacted by anthropologic activities. The unique characteristics of groundwater provide a special niche bacterial colonization. To maintain the sustainability ecosystem, good understanding influencing factors and assembly mechanisms communities necessary. Here, we investigated from two industrial zones in Shanghai, highly industrialized city, during wet dry seasons using high-throughput...
Gliomas are the most common primary malignant brain tumors and have a poor prognosis. Early detection of gliomas is crucial to improve patient outcomes. Urine accumulates systematic body changes thus serves as an excellent early biomarker source.At discovery phase, we performed self-controlled proteomics analysis by comparing urine samples collected from five glioma patients at time tumor diagnosis after surgical removal tumor. At validation further validated some promising proteins using...
The burial of organic carbon (OC) in the river-dominated margin plays an important role global cycle, but its accumulation mechanism is not well understood. Here, we examined concentration and distribution water-extractable matter (WEOM) base-extractable (BEOM) surface sediments from lower Yangtze River, estuary, East China Sea. Chemical characteristics WEOM BEOM were described by multiple ultraviolet-visible fluorescence spectral indicators. Concentrations both showed significant...
Carotid atherosclerosis (CAS) is an important cause of stroke. Although interactions between the gut microbiome and metabolome have been widely investigated with respect to pathogenesis cardiovascular diseases, information regarding CAS remains limited.We utilized 16S ribosomal DNA sequencing untargeted metabolomics investigate alterations in microbiota plasma metabolites 32 patients healthy controls. The compositions differed significantly two groups, a total 11 differentially enriched...