A5100379540- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Advanced Proteomics Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Cell Adhesion Molecules Research
- RNA modifications and cancer
- Sleep and Work-Related Fatigue
- Atherosclerosis and Cardiovascular Diseases
- Glycosylation and Glycoproteins Research
- Circular RNAs in diseases
- CRISPR and Genetic Engineering
- Single-cell and spatial transcriptomics
- Immune Response and Inflammation
- Plant Virus Research Studies
- Cancer-related Molecular Pathways
- Gut microbiota and health
- Gastrointestinal Tumor Research and Treatment
- Sleep and related disorders
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- Neurological Disease Mechanisms and Treatments
- Ginseng Biological Effects and Applications
- Microbial Metabolic Engineering and Bioproduction
- Kruppel-like factors research
Harbin Medical University
2016-2025
Dalian Institute of Chemical Physics
2020-2025
Chinese Academy of Sciences
2020-2025
Huazhong University of Science and Technology
2022-2025
Union Hospital
2025
Beijing Satellite Navigation Center
2025
Liaoning Normal University
2024
Northeast Forestry University
2021-2024
Central South University of Forestry and Technology
2024
Central South University
2024
Purpose: Most patients with pancreatic ductal adenocarcinoma (PDAC) have vascular invasion and metastasis, leading to low surgical resection rate dismal prognosis. Tumor angiogenesis is related metastasis. However, anti-angiogenesis therapeutic effects in PDAC are limited. Therefore, it imperative explore molecular mechanism of PDAC. Experimental Design: scRNA-seq data were utilized delineatetranscriptional profiles endothelial cells The vitro vivo models used the role derived exosomes under...
Abstract Flowering time of rice ( Oryza sativa L. ) is among the most important agronomic traits for region adaptation and grain yield. In process breeding, efficient slightly modulating flowering an elite cultivar would be more popular with breeder. Hence, we are interested in increasing expression repressors by CRISPR/Cas9 genome editing system. It was predicated there were three uORFs 5’ leader sequence Hd2 . this study, through uORFs, got four homozygous mutant lines. Phenotypic analysis...
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6 inhibitors) can significantly extend tumor response in patients with metastatic luminal A breast cancer, yet intrinsic acquired resistance remains a prevalent issue. Understanding the molecular features of CDK4/6 inhibitor sensitivity potential efficacy their combination novel targeted cell death inducers may lead to improved patient outcomes. Herein, we demonstrate that ferroptosis, form regulated driven by iron-dependent phospholipid...
Abstract Urinary proteomics is emerging as a potent tool for detecting sensitive and non-invasive biomarkers. At present, the comparability of urinary data across diverse liquid chromatography−mass spectrometry (LC-MS) platforms remains an area that requires investigation. In this study, we conduct comprehensive evaluation proteome multiple LC-MS platforms. To systematically analyze assess quality large-scale data, develop control (QC) system named MSCohort, which extracted 81 metrics...
There is a potential correlation between vitiligo and gut microbiota, although research in this area currently limited. The employed high-throughput sequencing of 16S rRNA to examine the microbiome stool samples 49 individuals with without condition. study encompassed four comparison groups: (1) DI (disease) group vs. HC (healthy control) group; (2) DI_m (disease minors) HC_m control minors); (3) DI_a (adult disease group) HC_a healthy group); (4) group. Research findings have indicated...
Alterations in liver metabolism play a pivotal role the development and progression of metabolic dysfunction-associated steatotic disease (MASLD). Asprosin is reported to be released from white adipose tissue during fasting targets liver. However, asprosin, especially organs other than tissue, MASLD remains poorly understood. These findings demonstrate that plasma asprosin levels are significantly elevated patients animal models. Additionally, expression increased mice. Hepatocyte-specific...
Influenza causes considerable morbidity and mortality in China, but its impact on the health-related quality of life (HRQoL) has not been previously measured.We conducted a retrospective telephone survey to assess influenza HRQoL among outpatients inpatients using EuroQoL EQ-5D-3 L instrument. Participants were individuals with laboratory-confirmed infection registered by National Influenza-like-illness Surveillance Network 2013.We interviewed 839 11,098 eligible patients. After excluding...
Abstract Agrobacterium rhizogenes -mediated transformation is widely used in different species with various purposes. The development of composite plants (wild-type shoot transgenic roots) has been a milestone for functional characterization genes. Previously, were generated by two steps from inducing hairy roots to growing the growth medium. Hairy induced an induction medium and another produced was subject transplanting. Here, we describe improved optimized protocol generation plant...
Abstract 2,5-Dimethylpyrazine (2,5-DMP) is important pharmaceutical raw material and food flavoring agent. Recently, engineering microbes to produce 2,5-DMP has become an attractive alternative chemical synthesis approach. In this study, metabolic strategies were used optimize the modified Escherichia coli BL21 (DE3) strain for efficient of using L -threonine dehydrogenase ( Ec TDH) from BL21, NADH oxidase Eh NOX) Enterococcus hirae , aminoacetone Sc AAO) Streptococcus cristatus transporter...
Single-cell multi-omics analysis can provide comprehensive insights to study cell-to-cell heterogeneity in normal and disease physiology. However, due the lack of amplification technique, measurement proteome metabolome same cell is challenging. Herein, a novel on-capillary alkylation micro-reactor (OCAM) was developed achieve proteo-metabolome profiling single cells, by which proteins were first covalently bound an iodoacetic acid functionalized open-tubular capillary via sulfhydryl...