A5101472401- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cervical Cancer and HPV Research
- Advanced Nanomaterials in Catalysis
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Bladder and Urothelial Cancer Treatments
- Advanced biosensing and bioanalysis techniques
- Food Industry and Aquatic Biology
- Moyamoya disease diagnosis and treatment
- Thermoregulation and physiological responses
- MXene and MAX Phase Materials
- Protein Hydrolysis and Bioactive Peptides
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Osteoarthritis Treatment and Mechanisms
- Thermal Regulation in Medicine
- Elevator Systems and Control
- Thyroid Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Phytochemical and Pharmacological Studies
Chinese University of Hong Kong
2021-2024
China Pharmaceutical University
2023-2024
Affiliated Hospital of Nantong University
2019-2024
Nantong University
2019-2024
Second Affiliated Hospital of Nantong University
2019-2024
Hunan Normal University
2023-2024
Hunan Provincial People's Hospital
2023-2024
Weatherford College
2024
Second People's Hospital of NanTong
2024
Sichuan Mianyang 404 Hospital
2023
Clear cell renal carcinoma (CCRCC) is characterized by a highly metastatic potential. The stromal communication between stem cells and cancer critically influences dissemination of cells.The effect exosomes isolated from (CSCs) CCRCC patients on the progress epithelial-mesenchymal transition (EMT) lung metastasis were examined.CSCs promoted proliferation accelerated EMT. Bioactive miR-19b-3p transmitted to CSC induced EMT via repressing expression PTEN. CSCs derived with produced strongest...
Osteoarthritis (OA) is a very common chronic and degenerative joint disease characterized by persistent destruction of articular cartilage. Recently, increasing evidence showed that circular RNAs (circRNAs) play critical roles in OA progression. However, the functions circRNAs their underlying mechanisms action remain unclear. In present study, expression levels circRNA-UBE2G1 HIF-1a were significantly increased tissues, whereas miR‑373 was downregulated. Function assays inhibition reduced...
Emerging studies demonstrate that PIWI-interacting RNAs (piRNAs) are associated with various human cancers. This study aimed to evaluate the urinary extracellular vesicles (EVs) piRNAs as non-invasive biomarkers for prostate cancer (PCa) diagnosis. RNA was extracted from EVs five PCa patients and healthy controls (HC), were analyzed by small sequencing. Dysregulated identified then validated in another 30 10 HC reverse-transcription polymerase chain reaction (RT-qPCR). The expressions of...
Tumor vasculature and cancer stem cells (CSCs) accelerate the development of metastatic renal cancer. Dual inhibition vascular endothelium CSCs is still a challenge due to their different pathological features. Herein, transformable dual-inhibition system (TDS) based on self-assembly peptide proposed construct nanofibrous barriers cell membrane in situ, which contributes 1) reducing endothelial permeability angiogenesis; 2) inhibiting stemness metastasis TDS specifically targets...
Frizzled class receptor 1 (FZD1), a for Wnt signaling pathway. Overexpression of FZD1 has been detected in many cancer tissues and cells resulting tumor development drug resistance. However, its expression status prognostic merit renal still remains unclear. We screened the mRNA clear cell carcinoma (ccRCC) papillary (pRCC) from TCGA database Oncomine database. then sunitinib-resistant corresponding parental by qRT-PCR. level was significantly upregulated tissues, lines their cells. also...
Castration-resistant prostate cancer (CRPC) is the leading cause of (PCa)-related death in males, which occurs after failure androgen deprivation therapy (ADT).PIWI-interacting RNAs (piRNAs) are crucial regulators many human cancers, but their expression patterns and roles CRPC remain unknown.In this study, we performed small RNA sequencing to explore CRPC-associated piRNAs using 10 benign tissues, 9 paired hormone-sensitive PCa (HSPCa) tissues from same patients.PiRNA-4447944 (piR-4447944)...
Peripheral cerebral aneurysms are difficult to treat with preservation of the parent arteries. We report clinical and angiographic outcome 12 patients located peripherally. In past five years, patients, six females males, presented at our institution intracranial distal circle Willis were treated endovascularly. The age ranged from four 58 years a mean 37 years. Seven had subarachnoid and/or intracerebral hemorrhage upon presentation. Two P2 dissecting mild hemiparesis hypoesthesia, one...
Background: Osteoid osteoma (OO) is a benign lesion characterized by an increased fibrous component in the bone marrow, presence of bone-like structures within medullary cavity, and surrounding sclerotic rim. Reports on OO located posterior proximal tibia are rare. Case summary: Herein, we report case 18-year-old male, admitted for evaluation right knee pain. The pain had started 6 months prior without any apparent cause, which was notably severe at night, affecting sleep, exacerbated while...
We constructed heteropolysaccharide-based complex coacervate microdroplets using pectin and DEAE-dextran via electrostatic interactions. The were stable from pH 3 to 12 completely dissociated at a NaCl concentration of 160 mM. When cholesterol oxidase was distributed in the microdroplets, enzyme activity did not decrease, it made more stable. Through spiked recovery experiments serum comparison with results commercial assay kits, we successfully validated that can be used for detection real samples.
Abstract Oxidation-derived nanoparticles (CDs/TiO x ) of Ti 3 C 2 were prepared for the first time by simple oxidation . CDs/TiO was a two-dimensional hybrid amorphous carbon and titanium oxides with lateral dimension about 50 nm. H O used as oxygenator reduction product O, which environmentally friendly inexpensive. Carboxyl, carbonyl, hydroxyl groups are formed naturally during derivative process. The decreased size increases specific surface area provides possibility abundant presence...
Prostate cancer (PCa) is a prevalent malignant disease and the primary reason for cancer-related mortality among men globally. GLIS1 (GLIS family zinc finger 1) key regulator in various pathologies. However, expression pattern, clinical relevance, immunomodulatory function of PCa remain unclear. In this study, was discovered to serve as gene by integrating mRNA miRNA profiles from GEO database. We systematically explored prognostic values cancers using multiple databases. Additionally, we...
Bladder cancer (BC) is the most common malignancy involving urinary system, and characterized by a high recurrence rate. It important to identify potential lncRNA signatures capable of predicting tumour risk assessing prognosis in BC patients. We extracted data from The Cancer Genome Atlas identified 381 differentially expressed lncRNAs, 855 mRNAs 70 miRNAs between non-recurrent recurrent tissues. Subsequently, competing endogenous RNA (ceRNA) network composed 29 13 4 was established. used...
Motherwort exhibits a curative effect on kidney damage and its component, ajugol, also might improve damage. Therefore, this study assesses the mechanism whereby ajugol alleviates renal injury in multiple myeloma. After establishment of animal model myeloma ( n = 30), mice received treatment with low-dose high-dose 10, each group). And 10 healthy were taken as control group modeled untreated (model Following treatment, serum spinal cord samples collected, which levels Cys-C, RBP, Cr, UN, CD4...