A5032666798- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Photoacoustic and Ultrasonic Imaging
- Luminescence and Fluorescent Materials
- Polyoxometalates: Synthesis and Applications
- Chemical Synthesis and Reactions
- Phase Change Materials Research
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Extracellular vesicles in disease
- Carbon and Quantum Dots Applications
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Porphyrin and Phthalocyanine Chemistry
- Solar-Powered Water Purification Methods
- Electrochemical sensors and biosensors
- Nanomaterials for catalytic reactions
- Catalytic Processes in Materials Science
- Ga2O3 and related materials
- Adsorption and Cooling Systems
- Quantum Dots Synthesis And Properties
- Curcumin's Biomedical Applications
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
Harbin Institute of Technology
2016-2025
Shenzhen Technology University
2022-2025
China Pharmaceutical University
2025
Nanjing Drum Tower Hospital
2025
University of Science and Technology Beijing
2014-2024
Shenzhen University
2023
China University of Petroleum, East China
2020-2023
Shanghai University
2022
Shanghai University of Engineering Science
2020-2021
XinHua Hospital
2018-2020
Post-synthetic modification of four common transition-metal derived MOFs gives novel MOF–RNH<sub>2</sub>catalysts which show greatly enhanced Knoevenagel condensation reactivities towards various aldehyde electrophiles.
Csx WO3 nanorods coated with polyelectrolyte multilayers are developed as "four-in-one" multifunctional nanomaterials significant potential for computed tomography/photoacoustic tomography bimodal imaging-guided photothermal/photodynamic cancer treatment.
A theranostic system of image-guided phototherapy is considered as a potential technique for cancer treatment because the ability to integrate diagnostics and therapies together, thus enhancing accuracy visualization during treatment. In this work, we realized photoacoustic (PA) imaging-guided photothermal (PT)/photodynamic (PD) combined just via single material, MoO3−x quantum dots (QDs). Due their strong NIR harvesting ability, QDs can convert incident light into hyperthermia sensitize...
Purpose: The present study was to formulate curcumin solid lipid nanoparticles (Cur-SLNs) with P-gp modulator excipients, TPGS and Brij78, enhance the solubility bioavailability of curcumin.Methods: formulation optimized by Plackett–Burman screening design Box–Behnken experiment design. Then physiochemical properties, entrapment efficiency in vitro release Cur-SLNs were characterized. In vivo pharmacokinetics situ single-pass intestinal perfusion performed investigate effects on absorption...
In this study, highly dispersed Au nanoparticles have been immobilized on amino-functionalized metal–organic frameworks (MOFs) via a novel absorption/reduction method in solution. The amino functionality of the MOF rapidly coordinated with HAuCl4 and acted as Au(0) precursor absence protecting agents. resulting Au@MOF catalyst was well aqueous media taking advantage its well-defined uniform sizes nanomorphologies. as-synthesized exhibited high catalytic activities wide variety reactions...
Abstract Although nanomaterial‐mediated phototherapy, in particular photothermal therapy (PTT) and photodynamic (PDT), is extensively investigated recent years, the ablation mechanism, evolution, rehabilitation process of vivo solid tumor after phototherapy are rarely explored yet remain a terra incognita. Herein, kind bismuth ferrite nanoparticles (abbreviated as BFO NPs) strategically designed synthesized with desirable size bioactivity brand‐new phototherapeutic agent for which strong...
Abstract Radiotherapy (RT) is a popular clinical therapy method for extending cancer patient survival, but hampered by severe side effects and the weak effect. Herein, responsive degradable selenium (Se) theranostic agents (Se@SiO 2 @Bi nanocomposites (NCs)) are fabricated, which combine computed tomography (CT) imaging simultaneously enhance therapeutic of photothermal (PTT) RT, while reducing radiation. The Se@SiO can accumulate at tumor site, responsively decompose to releease Se,...
For the drawbacks of phase change materials such as poor shape stability and weak solar-thermal conversion ability, a rotunda-shaped carboxymethylcellulose/carbon nanotube aerogel (CA) with three-dimensional network was constructed by freeze casting special mold, then impregnated polyethylene glycol (PEG) in this work. The PEG/CA had an enthalpy 183.21 J/g, thermal conductivity 0.324 W m
A new thiourea-containing metal–organic framework (MOF) catalyst was synthesized. It overcomes recycling, self-aggregation and solvation issues that exist in homogeneous thiourea catalysts. Nanomorphology introduced to increase the dispersion of solid solvent. Acetalization Morita–Baylis–Hillman reactions were catalyzed using MOF catalyst.
Image-guided phototherapy is considered to be a prospective technique for cancer treatment because it can provide both oncotherapy and bioimaging, thus achieving an optimized therapeutic efficacy higher accuracy. Compared complicated systems with multiple components, using single material this multifunctional purpose preferable. In work, we strategically fabricated poly(acrylic acid)- (PAA-) coated Cu2(OH)PO4 quantum dots [denoted as Cu2(OH)PO4@PAA QDs], which exhibit strong near-infrared...
Chemodynamic therapy (CDT) is an emerging approach to treat cancer based on the tumor microenvironment (TME), but its limited content of endogenous hydrogen peroxide (H2O2) weakens anticancer effects. Herein, a multifunctional biomimetic nanozyme (Se@SiO2-Mn@Au/DOX, named as SSMA/DOX) fabricated, which undergoes TME responsive self-cascade catalysis facilitate MRI guided enhanced chemo/chemodynamic therapy. The SSMA/DOX nanocomposites (NCs) responsively degrade in acidic conditions release...
Dynamic therapies, which induce reactive oxygen species (ROS) production in situ through endogenous and exogenous stimulation, are emerging as attractive options for tumor treatment. However, the complexity of substantially limits efficacy individual stimulus-triggered dynamic therapy. Herein, bimetallic copper ruthenium (Cu@Ru) core–shell nanoparticles applied endo–exogenous stimulation-triggered The electronic structure Cu@Ru is regulated ligand effects to improve adsorption level small...
Abstract A novel metal–organic framework UiO‐66‐NH 2 ‐derived Brønsted acid catalyst was synthesized on a gram scale by employing postsynthetic modification strategy under mild conditions. The nanomorphology of the designed and developed to enhance its catalytic performance. Acetalization benzimidazole formation were evaluated demonstrate high reactivity selectivity nanoscaled UiO‐66‐NH‐RSO 3 H catalyst, which found be comparable strong homogeneous catalyst. Furthermore, recycled several...
Multidrug resistance (MDR) is a main clinical hurdle for chemotherapy of cancer, and overexpression P-glycoprotein (P-gp) key factor. In the present study, new co-delivery system reversing MDR was designed developed. The composed curcumin (Cur) piperine (Pip) encapsulated in solid lipid nanoparticles (SLNs) with tocopheryl polyethylene glycol succinate (TPGS) Brij 78 [(Cur+Pip)-SLNs]. TPGS could sensitize tumors by inhibiting P-gp drug efflux system. combination Cur Pip, when administered...
Abstract Aggregated β‐amyloid (Aβ) is widely considered as a key factor in triggering progressive loss of neuronal function Alzheimer's disease (AD), so targeting and inhibiting Aβ aggregation has been broadly recognized an efficient therapeutic strategy for curing AD. Herein, we designed prepared organic platinum‐substituted polyoxometalate, (Me 4 N) 3 [PW 11 O 40 (SiC H 6 NH 2 ) PtCl ] (abbreviated Pt II ‐PW 42 aggregation. The mechanism inhibition on by was attributed to the multiple...
Hypoxia, as a main feature of the tumor microenvironment, has greatly limited efficacy photodynamic therapy (PDT), well its clinical application. Here, multifunctional composite nanoplatform, peptide/Ce6/MnO2 nanocomposite (RKCM), been constructed to alleviate hypoxia and increase PDT using rationally designed peptide fibrils encapsulate chlorin e6 (Ce6) inside mineralize MnO2 nanoparticles on surface. As result, RKCM significantly improved by increasing reactive oxygen species (ROS)...