A5113107830- Hair Growth and Disorders
- Nanoplatforms for cancer theranostics
- Reproductive Biology and Fertility
- Autophagy in Disease and Therapy
- Phytoestrogen effects and research
- Medicinal Plants and Bioactive Compounds
- Lymphoma Diagnosis and Treatment
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- Metabolism, Diabetes, and Cancer
- Tea Polyphenols and Effects
- Viral-associated cancers and disorders
- GABA and Rice Research
- Nanoparticle-Based Drug Delivery
- Neurological Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Hedgehog Signaling Pathway Studies
- Cancer and Skin Lesions
- Cytomegalovirus and herpesvirus research
- T-cell and Retrovirus Studies
- Chemical Synthesis and Analysis
- Toxin Mechanisms and Immunotoxins
- Extracellular vesicles in disease
Shenzhen Technology University
2023-2025
Hebei University of Science and Technology
2024
Inner Mongolia Agricultural University
2024
Dynamic therapies, which induce reactive oxygen species (ROS) production in situ through endogenous and exogenous stimulation, are emerging as attractive options for tumor treatment. However, the complexity of substantially limits efficacy individual stimulus-triggered dynamic therapy. Herein, bimetallic copper ruthenium (Cu@Ru) core–shell nanoparticles applied endo–exogenous stimulation-triggered The electronic structure Cu@Ru is regulated ligand effects to improve adsorption level small...
The complex tumor microenvironment (TME) affects reactive oxygen species (ROS)-based therapies; breaking the limitations of TME to enhance effectiveness sonodynamic therapy (SDT) is full great challenges. Herein, iron atomically dispersed nanoparticles (Fe-N-C) were first reported as sonosensitizers with highly efficient ROS generation by overcoming limitations. Its peroxidase and catalase-like activities catalyze H2O2 produce toxic ·OH in situ O2, respectively, then O2 molecules adsorbed at...
Sonic hedgehog (Shh) is a component of the Hedgehog signaling pathway, playing an important role in regulating cell proliferation, differentiation, apoptosis, and repair damaged organisms. To further clarify expression pattern Shh gene secondary hair follicle growth cycle cashmere goats its mechanism action on papilla cells, improve quality, this study, we took Inner Mongolia Albas white as research objects collected skin samples at different stages to obtain follicles, detected by RT-qPCR,...
Background The growth of secondary hair follicles (SHFs) in cashmere goats has periodic changes, including telogen, anagen, and catagen, during which proteins play important roles as the executor life activities. Results In this study, skin tissues at three different stages SHFs were collected for proteome sequencing validation experiments. Through protein differential expression analysis time series analysis, FKBP prolyl isomerase 10 (FKBP10) fibrillin 2 (FBN2) screened key SHF cycle goats,...
Epstein-Barr virus (EBV) is a human oncogenic herpesvirus associating with several malignant diseases. Latent membrane protein 2 (LMP2) of EBV considered to be an ideal candidate for immunotherapy or prophylactic vaccine. We designed LMP2 multiepitope containing T and B-cell epitope-rich peptides constructed recombinant plasmid mammalian codonoptimization (pcDNA3.1(+)/EBV-LMP2 multiepitope). After pcDNA3.1(+)/EBV-LMP2 was transfected into COS-7 cells, significant expression the in cells...
Steroid hybrids have emerged as a type of advantageous compound they could offer improved pharmacological and pharmaceutical properties. Here, we report series novel peptides-dehydroepiandrosterone hybrids, which would effectively induce endoplasmic reticulum stress lead to apoptosis with outstanding in vitro vivo anti-melanoma effects. The IId among various steroids conjugated peptides pyridines showed great activity B16 xenograft mice: medium high dose treatment groups (60mg/kg 80mg/kg),...
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic disorders. Our previous study has demonstrated anti-NAFLD effect hawk tea extract (HTE) in vivo; however, underlying mechanism remains elusive. Here, ability HTE to decrease lipid accumulation was verified vitro. Western blot analyses revealed that inhibits de novo lipogenesis, and this abolished by AMP-activated kinase (AMPK) inhibitor. Transcriptomic analysis western blotting indicated downregulates rho-kinase 1...