A5039476835- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Biosensors and Analytical Detection
- Glioma Diagnosis and Treatment
- DNA and Nucleic Acid Chemistry
- Luminescence and Fluorescent Materials
- 2D Materials and Applications
- Photoacoustic and Ultrasonic Imaging
- Plasmonic and Surface Plasmon Research
- Neuroblastoma Research and Treatments
- Immune cells in cancer
- Neurofibromatosis and Schwannoma Cases
- Photodynamic Therapy Research Studies
- Circular RNAs in diseases
- Mechanical and Optical Resonators
- Advanced Nanomaterials in Catalysis
- Advanced Biosensing Techniques and Applications
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
- Neurosurgical Procedures and Complications
- Advanced Thermoelectric Materials and Devices
- Head and Neck Surgical Oncology
- Analytical Chemistry and Sensors
Jinan University
2019-2024
Southern University of Science and Technology
2021-2024
Shenzhen Technology University
2023-2024
Cornell University
2017-2022
Molecular Innovations (United States)
2017-2022
Memorial Sloan Kettering Cancer Center
2021
Hunan University
2014-2020
State Key Laboratory of Chemobiosensing and Chemometrics
2014-2020
Weill Cornell Medicine
2018-2020
Changsha University
2014-2016
Detection of C-reactive protein using nanoparticle-enhanced surface plasmon resonance an aptamer-antibody sandwich assay.
DNA nanostrucures are promising materials for biomedical applications. Herein, we established a "sense-and-treat" localized drug delivery system based on nanodevice to specifically destroy circulating tumor cells (CTCs) by synergetic chemotherapy and photodynamic therapy. The nanodevices could sense the existence of CTCs treat with anticancer agents. Typically, presence target cell promoted formation hairpin structure aptamer, then aptamer-accompanied tetrahedron would release from...
DNA aptamers for CRP were selected and investigated using SPR technology, which will be of benefit constructing sensors.
Abstract Background Skeletal muscle atrophy is a common clinical manifestation of various neurotrauma and neurological diseases. In addition to the treatment primary neuropathies, it condition that should be investigated. FoxO3 activation an indispensable mechanism in denervation‐induced atrophy; however, upstream factors control expression activity have not been fully elucidated. N 6 ‐methyladenosine (m A) methylation novel mode epitranscriptional gene regulation affects several cellular...
The blood-brain barrier (BBB) represents a major obstacle in delivering therapeutics to brain lesions. Convection-enhanced delivery (CED), method that bypasses the BBB through direct, cannula-mediated drug delivery, is one solution maintaining increased, effective concentration at these CED was recently proven safe phase I clinical trial against diffuse intrinsic pontine glioma (DIPG), childhood cancer. Unfortunately, exact relationship between size, charge, and pharmacokinetic behavior...
Background: Radiotherapy is an indispensable part of the multidisciplinary treatment breast cancer (BC). Due to potential for serious side effects from ionizing radiation in cancer, which can adversely affect patient’s quality life, dose often limited. This limitation result incomplete eradication tumors. Methods: In this study, biomimetic copper single-atom catalysts (platelet cell membrane camouflaging, PC) were synthesized with aim improving therapeutic outcomes radiotherapy BC. Following...
The effects of medicine on the biomolecular interaction have been given increasing attention in biochemistry and affinity-based analytics since environment vivo is complex especially for patients. Herein, myoglobin, a biomarker acute myocardial infarction, was used as model, interactions myoglobin/aptamer myoglobin/antibody were systematically investigated using atomic force microscopy (AFM) first time. results showed that average binding probability almost remained unchanged after...
In vivo, real-time image-guided CED of a PET-imageable HDAC inhibitor is needed to improve survival in murine models DIPG.
Pancreatic polypeptide (PP) is a specific biomarker of nonfunctional pancreatic neuroendocrine tumors (NF-pNETs). Clinical significance PP inspires researchers to make great efforts in developing sensitive and sensors. However, there no existing biosensor for detecting that combines facility functionality. Addressing this challenge, pair aptamers which could be used develop sandwich assay reported. First, several high affinity are screened through graphene oxide-based SELEX, appropriate...
We developed a simple label-free aptamer-based method for C-reactive protein (CRP) detection.
The novel synthesis of a dual-modality, pentamethine cyanine (Cy5) fluorescent, 18F positron emission tomography (PET) imaging probe is reported. shows large extinction coefficient and quantum yield in the biologically transparent, near-infrared window (650-900 nm) for vivo fluorescent imaging. This fluorophore bears isotope, 18F, giving 18F-PET/near-infrared (NIRF), bi-modal probe, that combines long-term stability NIRF unlimited penetration depth PET labeled with quick, one-step reaction,...
A proof of concept study: inhibiting tumor metastasis with irradiation.
The impact of donor strength on Bodipys’ optical properties and its applications for tumor near-infrared fluorescence imaging photoacoustic tomography.
Clinical trials involving genome-edited cells are growing in popularity, where CAR-T immunotherapy and CRISPR/Cas9 editing more recognized strategies. Genetic reporters needed to localize the molecular events inside these patients. Specifically, a nonimmunogenic genetic reporter is urgently as current immunogenic due derivation from nonhuman sources. Prostate-specific membrane antigen (PSMA) potentially its natural, low-level expression select tissues (self-MHC display). PSMA overexpression...
Fluorescein is modified to bear 18F so that it can act as both a positron emitter, and fluorophore, allowing detection by emission tomography (PET), scintillation, fluorescent imaging (FL). [18F]-2 injected into the intrathecal space of rats used observe cerebrospinal fluid (CSF) bathes brain spine. Injury in three different applications visualized with [18F]-2: 1) 0.7 mm paranasal-sinus CSF leak (CSFL); 2) 0.5 puncture damage thoracic spine (acute spinal cord injury); 3) intracerebral...
G-quadruplexes are guanine-rich nucleic acid sequences that can act as universal signal-transducers and generate colorimetric, fluorescence, chemiluminescence signals when complexed with different ligands.
A self-assembled DNA nanostructure based on a nanocreeper and multiplexed fluorescence supersandwich was designed for the sensitive specific detection of tumour cells. This could improve binding affinity current aptamers trigger signal amplification, which provide potential discrimination low abundant target cells in liquid biopsy.
With the development of combinatorial chemistry and high-throughput screening, number hydrophobic drug candidates continues to increase. However, low solubility drugs could induce erratic absorption patterns affect efficacy. Aptamers are artificially selected highly water-soluble oligonucleotides that bind ions, small molecules, proteins, living cells, even tissues. Herein, increase drug, we screened aptamer by exploiting DNA library immobilization selection strategy microfluidic technology....
<sec>Developing efficient thermoelectric materials has never lost the attraction due to their promising performances in energy conversion. The different mechanisms of phonon scattering lead various outstanding layered properties. So we investigate structure, electronic and transport properties Penta-<i>X</i>Te<sub>2</sub> (<i>X</i> = Pd, Pt) layers based on density functional theory Boltzmann theory. Those monolayers have a beautiful...