A5100742446- Genomics and Phylogenetic Studies
- Plant and Fungal Species Descriptions
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Diatoms and Algae Research
- Spinal Cord Injury Research
- Plant Diversity and Evolution
- Plant Pathogens and Fungal Diseases
- RNA Research and Splicing
- Botulinum Toxin and Related Neurological Disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Neutropenia and Cancer Infections
- Genomics and Chromatin Dynamics
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Pediatric Pain Management Techniques
- Microbial Community Ecology and Physiology
- DNA Repair Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Phytochemical compounds biological activities
- Surfactants and Colloidal Systems
First Affiliated Hospital of Jinan University
2012-2025
Jinan University
2021-2024
University of California, Los Angeles
2024
Wuhan Botanical Garden
2019-2024
Chinese Academy of Sciences
2019-2024
University of Chinese Academy of Sciences
2019
Genomics Institute of the Novartis Research Foundation
2019
Beijing Anzhen Hospital
2014
Capital University
2014
Capital Medical University
2014
In budding yeast, acetylation of histone H3 lysine 56 (H3-K56) is catalyzed by the Rtt109-Vps75 acetyltransferase (HAT) complex, with Rtt109 being catalytic subunit, and chaperone Asf1 required for this modification. Cells lacking are susceptible to perturbations in DNA replication. However, how regulates H3-K56 loss affects replication unclear. We show that at low concentrations HAT complex acetylates vitro when H3/H4 complexed Asf1, but not tetramers, recapitulating vivo requirement using...
Abstract Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the microarchitecture, leading to an increased risk fractures. Recently, circular RNAs (circRNAs) have been demonstrated play pivotal roles in regulating metabolism. However, underlying functions circRNAs metabolism postmenopausal remain obscure. Here, we report that circStag1 critical osteoporosis-related circRNA shows significantly downregulated expression osteoporotic marrow...
Acetylation of lysine 56 histone H3 (H3-Lys-56) occurs in S phase and disappears during G(2)/M the cell cycle. However, it is not clear how this modification regulated progression We others have shown that acetyltransferase (HAT) Rtt109 primary HAT responsible for acetylating H3-Lys-56 budding yeast. Here we show forms a complex with Vps75 both recombinant Rtt109-Vps75 complexes native purified from yeast cells acetylate present H3/H4/H2A/H2B core histones but other histones. In addition,...
spinal cord injury (SCI) disrupts the gut microbiota, worsening injury's impact. Fecal microbiota transplantation (FMT) is increasingly recognized as a promising strategy to improve neural function post-SCI, yet its precise mechanisms are still far from clear. The present study aims elucidate how FMT influences motor recovery and underlying utilizing SCI mouse model. Mice with received healthy donors. We used 16 S rRNA amplicon sequencing analyze alterations of microbes. Pathological in...
Tree transplantation, as a key measure in municipal landscaping construction, plays significant role rapidly improving the level of urban greening and ecological environment. Due to tall stature complex root system large trees, transplantation process is difficult time-consuming, requiring precisecontrol over multiple stages such tree selection, cutting, lifting, planting. Meanwhile, maintenance transplanted trees also crucial ensure their survival good growth new This study deeply explores...
Previous work has shown that the N terminus of Saccharomyces cerevisiae Sir3 protein is crucial for function in transcriptional silencing. Here, we show overexpression N-terminal fragments strains lacking full-length can lead to some silencing HML and HMR. contains a BAH (bromo-adjacent homology) domain at its terminus. Overexpression this alone as long Sir1 overexpressed Sir2 Sir4 are present. closely related Orc1 also silence absence any protein. A previously characterized hypermorphic...
Abstract Background Skeletal muscle atrophy is a common clinical manifestation of various neurotrauma and neurological diseases. In addition to the treatment primary neuropathies, it condition that should be investigated. FoxO3 activation an indispensable mechanism in denervation‐induced atrophy; however, upstream factors control expression activity have not been fully elucidated. N 6 ‐methyladenosine (m A) methylation novel mode epitranscriptional gene regulation affects several cellular...
Bone remodeling is a dynamic process between bone formation mediated by osteoblasts and resorption osteoclasts. Disrupted key factor in postmenopausal osteoporosis, metabolic disorder characterized deteriorated microarchitecture increased risk of fracture. Recent studies have shown that piwi-binding RNA (piRNA) involved the pathogenesis certain diseases at post-transcriptional level. Here, we analyzed piRNA-63049 (piR-63049), which may play an essential role remodeling. The expression...
Long noncoding RNA (lncRNA) has emerged as a pivotal regulator improving neural regeneration in the progression of spinal cord injury (SCI). However, whether lncRNAs can be targeted for therapeutic intervention SCI remains unclear. In this study, we found that LINC00707 expression was significantly up-regulated lipopolysaccharide (LPS)-treated PC-12, model mimics nerve cell an inflammatory environment after SCI. Suppression alleviated LPS-induced inflammation and apoptosis PC-12 cells....
The transient build-up of DNA supercoiling during the translocation replication forks threatens genome stability and is controlled by topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. However, pinpointing cellular determinants best clinical response to still remains enigmatic. Here, we present an integrated approach demonstrate that endogenous exogenous expression oncofetal high-mobility group AT-hook 2 (HMGA2) protein exhibited broad...
Chloroplasts are typically inherited from the female parent and haploid in most angiosperms, but rare intra-individual heteroplasmy plastid genomes has been reported plants. Here, we report an example of plastome its characteristics
Abstract Background: High microsatellite instability (MSI-H) is highly prevalent across many cancer types including endometrium, gastric, ovary and colorectal cancer. It well known that there a clear synthetic lethality (SL) interaction between MSI-H Werner syndrome protein (WRN) inhibition. WRN member of RecQ helicase family involved in the maintenance genome integrity. Different from other members, has two activity centers responsible for exonuclease activity, respectively. Further studies...
<title>Abstract</title> Transcription factor Foxk1 can regulate cell proliferation, differentiation, metabolism, and promote skeletal muscle regeneration cardiogenesis. However, the roles of in bone formation is unknown. Here, we showed that expression decreased tissue aged mice osteoporosis patients. Knockdown primary murine calvarial osteoblastssuppressedosteoblast differentiation proliferation. Conditional knockout preosteoblasts mature osteoblasts exhibited mass mechanical strength due...
ABSTRACT In this paper, the binding properties of teicoplanin and vancomycin to bovine serum albumin (BSA) were investigated using fluorescence quenching, synchronous fluorescence, Fourier transform infrared (FTIR), circular dichroism (CD) UV–vis spectroscopic techniques molecular docking under simulative physiological conditions. The results obtained from quenching data revealed that drug–BSA interaction altered conformational structure BSA. Meanwhile, 3D CD, FTIR demonstrated conformation...
Abstract In this work, the interaction of chlortetracycline with bovine serum albumin (BSA) was investigated by fluorescence spectroscopy, circular dichroism (CD) and molecular docking. Results indicated that quenches BSA mainly a static quenching mechanism. The constants ( K SV ) were obtained as 5.64 × 10 4 , 4.49 4/ 3.44 M −1 at 283, 295, 307 K, respectively. thermodynamic parameters enthalpy change Δ H°, entropy S°, free energy G° −5.12 J mol−1, −97.6 mol−1 K−1, −2.24 (295 K),...
Abstract The transient build-up of DNA supercoiling during the translocation replication forks threatens genome stability and is controlled by topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. However, pinpointing cellular determinants best clinical response to still remains enigmatic. Here, we present an integrated approach demonstrate that endogenous exogenous expression oncofetal high-mobility group AT-hook 2 (HMGA2) protein exhibited...
Abstract Background Interest in the evolution of climatic niches, particularly understanding potential adaptive responses species under climate change, has increased both theoretically and within macroecological studies. These studies have provided valuable insights into how traits influence their niche evolution. In this study, we aim to investigate whether conservatism plays a role diversification Nymphaea , group aquatic plants with cosmopolitan distribution that is facing severe habitat...
Abstract Background Cliffs are recognized as one of the most challenging environments for plants, characterized by harsh conditions such drought, infertile soil, and steep terrain. However, they surprisingly host ancient diverse plant communities play a crucial role in protecting biodiversity. The Taihang Mountains, which act natural boundary eastern China, support rich variety species, including many unique to cliff habitats. it is little known how plants adapt habitats demographic history...
Abstract Background: Methylthioadenosine phosphorylase (MTAP) gene deletion is highly prevalent across many cancer types such as brain, pancreatic and lung cancer. Accumulated MTA in MTAP loss cells competes with S-adenosylmethionine (SAM, the methyl donor) leads to partial inhibition on protein arginine methyltransferase 5 (PRMT5), resulting sensitivity of these PRMT5 inhibition. On this basis, cooperative inhibitors (such MRTX1719 TNG908) have been designed stabilize binding MTA, but not...