A5102956353- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Spinal Cord Injury Research
- Cancer, Hypoxia, and Metabolism
- Spinal Fractures and Fixation Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Acupuncture Treatment Research Studies
- RNA Interference and Gene Delivery
- Autoimmune and Inflammatory Disorders Research
- Grief, Bereavement, and Mental Health
- Mesenchymal stem cell research
- Bladder and Urothelial Cancer Treatments
- Palliative Care and End-of-Life Issues
- Vascular Anomalies and Treatments
- Spondyloarthritis Studies and Treatments
- Pain Mechanisms and Treatments
- Inflammation biomarkers and pathways
- NF-κB Signaling Pathways
- Spinal Dysraphism and Malformations
- Effects of Vibration on Health
- Medical Imaging and Analysis
- Family and Patient Care in Intensive Care Units
- Pesticide Residue Analysis and Safety
- Angiogenesis and VEGF in Cancer
Guangzhou Medical University
2024-2025
First Affiliated Hospital of Guangzhou Medical University
2024
Jinan University
2018-2021
University of Pittsburgh
1996
Abstract Neuroinflammation is critically involved in the repair of spinal cord injury (SCI), and macrophages associated with inflammation propel degeneration or recovery pathological process. Currently, efforts have been focused on obtaining efficient therapeutic anti‐inflammatory drugs to treat SCI. However, these are still unable penetrate blood barrier lack ability target lesion areas, resulting unsatisfactory clinical efficacy. Herein, a polymer‐based nanodrug delivery system constructed...
Immune cell infiltration and neuroinflammation are heavily associated with spinal cord injury (SCI). C-C motif chemokine ligand 2/C-C receptor type 2 (CCL2/CCR2) axis has been identified as a critical role player during the invasion of immune cells to lesions in many diseases. γδ T cells, subgroup manage course inflammation response various diseases; however, it remains unknown whether recruited site through CCL2/CCR2 signaling exert regulation effect on after SCI.Basso Mouse Scale (BMS),...
Traumatic spinal cord injury (SCI) is a devastating condition marked by permanent motor, sensory, and autonomic dysfunction, in which the inflammatory response serves an important preventable role. High mobility group box-1 (HMGB1) potent regulator of inflammation numerous acute chronic conditions.; however, role HMGB1 SCI remains unclear. The present study aimed to characterize temporal dynamics release after SCI, investigate microglia activation mediating effects on explore therapeutic...
<h3>Background:</h3> Interleukin-1α (IL-1α) has potent antitumor activity either alone or combined with alkylating agents such as cisplatin and mitomycin C porfiromycin. Cisplatin is an effective chemotherapeutic agent in the treatment of advanced squamous cell carcinoma head neck (SCCHN). In murine SCCVII/SF tumor model, IL-1α induced acute hemorrhagic necrosis increased clonogenic kill. <h3>Objective:</h3> To determine efficacy IL-lα, singly combination, SCCHN. <h3>Methods:</h3> Syngeneic...
To investigate the biomechanical effects of osteoporosis on adjacent segments after posterior lumbar interbody fusion (PLIF).This study was designed and conducted in Traumatology Orthopedics Laboratory, School Chinese Medicine, Jinan University, Guangzhou, China, between December 2019 February 2020. A healthy finite element model L3-S1 developed along with one PLIF model. Based a hybrid test method, inferior surface S1 entirely fixed, preload 400N combined an adjusted moment imposed superior...
Nanotherapeutics for Spinal Cord Injury In article number 2102102, Zhizhong Li, Tianfeng Chen, and co-workers design a polymer-based nano drug delivery system conjugating with MMPs-responsive molecule to target the injury site, regulate polarization of macrophages exert neuroprotective effects promote locomotor recovery.