A5030784466- Immune cells in cancer
- Orthopaedic implants and arthroplasty
- Cervical and Thoracic Myelopathy
- Nanoplatforms for cancer theranostics
- Spine and Intervertebral Disc Pathology
- Bone Tissue Engineering Materials
- Titanium Alloys Microstructure and Properties
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Psoriasis: Treatment and Pathogenesis
- Nuclear Physics and Applications
- Infectious Aortic and Vascular Conditions
- Spinal Hematomas and Complications
- Spinal Cord Injury Research
- Spinal Fractures and Fixation Techniques
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Imaging and Analysis
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Advanced materials and composites
First Affiliated Hospital of Jinan University
2020-2023
Jinan University
2020-2022
Xuzhou Medical College
2020
ABSTRACT Besides surgical decompression, neuroprotection and neuroinflammation reduction are critical for acute spinal cord injury (SCI). In this study, we prepared small extracellular vesicles (sEVs) from immortalised mesenchymal stem cells overexpressing brain‐derived neurotrophic factor (BDNF) evaluated whether intranasal administration of BDNF‐sEVs is a therapeutic option SCI. cultured neurons, BDNF loading enhanced neurite outgrowth promoted by sEVs. After administration,...
β-Type Ti alloys have been widely investigated as implant materials owing to their excellent mechanical properties, corrosion resistance, and biocompatibility. In the present work, effects of Zr on microstructure, behaviors Ti–Zr–Mo–Mn were systematically studied. With increase content, phase composition gradually changed from intragranular-α + β (TZ)5:1MM alloy grain-boundary-α (TZ)2:1MM finally transferred a single structure (TZ)1:1MM alloy. The exhibited good combination with yield...
In this study, pore size and porosity distribution of porous Ti-6Al-4V scaffolds (pTi) were controlled by 3D printing. The effects at a constant porosity, or pertaining to functions adhesion, proliferation, differentiation the mouse embryonic osteoblast precursor (MC3T3-E1) cells researched separately.3D printing was used design five groups pTi, designated as PS300/HP, PS300/LP, PS500/HP, PS500/LP, PS800/HP based on distribution. MC3T3-E1 cultured non-porous samples (npTi) prepared control....
Background: Anterior cervical discectomy and fusion (ACDF) sacrifices segmental mobility, which can lead to the acceleration of adjacent segment degeneration. The challenge has promoted artificial disc replacement (CADR) as a substitute for ACDF. However, CADR revealed series new issues that are not found in ACDF, such hypermobility, subsidence, wear phenomenon. This study designed subtotal prosthesis (CSDP) consisting structure (CDP structure), vertebra fixation (CVF link structure, locking...
Objective: To evaluate the biological function of cervical subtotal discectomy prosthesis (CSDP) implantation in a non-human primate model. Methods: A CSDP was tested for cytocompatibility and osseointegration capacity before primates. Subsequently, improved based on three-dimensional CT measurements spine. Eight cynomolgus monkeys were selected removal intervertebral disc lower endplate C5/6 segment to complete model construction implantation. In 18-month follow-up, physiological indices,...
Abstract New strategies enhancing both cellular immune response and targetability of tumor immunomodulator remain a major challenge for the immunotherapy in solid tumor. In this research, novel biomimetic immuno-chemotherapy composite nanoparticle system was designed as breast tumors targeted drug. The cell membranes were modified by glycosyl-phosphatidylinositol (GPI) anchored anti-HER2 single chain variable fragment (scFv) GPI co-stimulatory molecule CD80; coated on mesoporous silica...
Abstract New strategies enhancing both targetability of chemotherapy drugs and synergistic effects immunotherapy remain a major challenge for the solid tumor therapy. In this research, novel biomimetic nanoparticle system possessed function targeting immune synergy was designed to accomplish above requirements. The membranes coated on mesoporous silica nanoparticles loaded with named doxorubicin (DOX); it modified by glycosyl-phosphatidylinositol (GPI) anchored anti-HER2 single chain...