A5100355649- Respiratory Support and Mechanisms
- MicroRNA in disease regulation
- Hemodynamic Monitoring and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Arrest and Resuscitation
- Knee injuries and reconstruction techniques
- Thermal Regulation in Medicine
- Poisoning and overdose treatments
- Total Knee Arthroplasty Outcomes
- Intensive Care Unit Cognitive Disorders
- Paraquat toxicity studies and treatments
- Heart Rate Variability and Autonomic Control
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Circular RNAs in diseases
- Thermoregulation and physiological responses
- Spinal Fractures and Fixation Techniques
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 Clinical Research Studies
- Vagus Nerve Stimulation Research
- Pesticide Exposure and Toxicity
- Sepsis Diagnosis and Treatment
- Physiological and biochemical adaptations
- Ultrasound in Clinical Applications
Gaochun People's Hospital
2019-2025
West China Second University Hospital of Sichuan University
2025
Sichuan University
2017-2025
Observational & Pragmatic Research Institute
2025
Fudan University
2019-2025
Anhui University
2024
Anhui University of Traditional Chinese Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Anhui University of Science and Technology
2023
Peking Union Medical College Hospital
2023
BACKGROUND Although microRNAs (miRNAs) play essential roles in spermatogenesis, little is known about seminal plasma miRNAs infertile men. We investigated the profile of men to identify that are altered infertility; we then evaluated their diagnostic value. METHODS Seminal samples were obtained from 289 and 168 age-matched fertile control individuals. The stability was first assessed by time-course freeze–thaw cycle analyses. Solexa sequencing technology used for an initial screen pooled 45...
Abstract The new outbreak of Coronavirus Disease 2019 (COVID-19) has emerged as a serious global public health concern. A more in-depth study blood coagulation abnormality is needed. We retrospectively analyzed 147 consecutive patients with COVID-19 who were admitted to three ICUs in Wuhan from February 9th, 2020 March 20th, 2020. baseline and other characteristics studied. Our results showed that the prolonged PT, FDP, DD positively correlated levels neutrophils, ferritin, LDH, total...
The pathological mechanisms of diabetic retinopathy (DR), a leading cause blindness in adults with diabetes mellitus, remain incompletely understood. Because microRNAs (miRNAs) represent effective DR therapeutic targets, we identified aberrantly expressed miRNAs associated cellular dysfunction early and detected their potential targets. We exposed human retinal endothelial cells (HRECs) cell line pigment epithelial (RPE) to high glucose (25 mmol/L, 1–7 days) mimic progression used...
Biologics targeting immunoglobulin E, interleukin (IL)-4/IL-13 or IL-5 signaling are effective at treating severe asthma; however, individual patients' responses may be suboptimal, leading to therapy switching stopping. The CLEAR study aimed assess real-world biologic use patterns and associated clinical outcomes in patients receiving care for asthma. was a multicenter, observational that included adults (≥18 years old) from 23 countries enrolled the International Severe Asthma Registry...
1) To evaluate the ability of pulse pressure variation adjusted by respiratory changes in pleural to predict fluid responsiveness compared with alone. 2) identify factors explaining poor performance acute distress syndrome.Prospective study.Forty-bed university hospital general ICU.Ninety-six mechanically ventilated syndrome patients requiring challenge.Fluid challenge, 500 mL saline over 20 minutes.Before esophageal was measured at end-inspiratory and end-expiratory occlusions. Change...
Kawasaki disease shock syndrome (KDSS) refers to (KD) patients who present more than 20% decrease in systolic blood pressure compared healthy individuals of the same age, or those show peripheral circulation perfusion disorder. KDSS may have varied clinical courses and could be easily ignored misdiagnosed. Yet, this deleterious, especially when combined with coronary artery injury multiple organ dysfunctions. Therefore, early diagnosis through specific manifestations is critical. This...
The commonly used single tests, based on a 1-time measurement of physiologic variable, are often poorly predictive tracheal extubation outcome because they examine only aspect physiological function that affects the outcome. We hypothesized construction decision-tree model, which includes multiple variables and considers changes these variables, may more accurately predict successful extubation.This was prospective observational study. From 2007 to 2008, 113 elderly patients in medical...
Clinical decision of extubation is a challenge in the treatment patient with invasive mechanical ventilation (IMV), since existing protocols are not capable precisely predicting failure (EF). This study aims to develop and validate interpretable recurrent neural network (RNN) models for dynamically EF risk.A retrospective cohort was conducted on IMV patients from Medical Information Mart Intensive Care IV (MIMIC-IV) database. Time series 4-h resolution were built all included patients. Two...
Background: Anterior cervical discectomy and fusion (ACDF) sacrifices segmental mobility, which can lead to the acceleration of adjacent segment degeneration. The challenge has promoted artificial disc replacement (CADR) as a substitute for ACDF. However, CADR revealed series new issues that are not found in ACDF, such hypermobility, subsidence, wear phenomenon. This study designed subtotal prosthesis (CSDP) consisting structure (CDP structure), vertebra fixation (CVF link structure, locking...
The present study retrospectively analyzed 170 patients diagnosed with paraquat (PQ) poisoning the aim of clarifying whether arterial lactate-time (arterial lactate concentration × time between ingestion and measurement) was a good predictor mortality in acute PQ poisoning. results indicated that there positive correlation concentration-time (ρ=0.485). In addition, data exhibited similar discriminative power to plasma (z=0.712; P=0.864). For receiver operating characteristic curve analysis,...
High-flow oxygen therapy has been widely adopted, but its use for weaning patients from mechanical ventilation not reported.To evaluate whether high-flow improves the efficiency of ventilation.In a single-center, prospective study, receiving were randomly assigned to 1 3 groups (T-tube, pressure support ventilation, or oxygen) during 2-hour spontaneous breathing trials in 14-day study. Participants followed up until hospital discharge death.Of 268 included, 90 T-tube group, 96 and 82 group....