Kui Shen

ORCID: 0000-0003-1678-3823
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About
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Research Areas
  • Spinal Cord Injury Research
  • Ombudsman and Human Rights
  • China's Socioeconomic Reforms and Governance
  • Selenium in Biological Systems
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Insect and Pesticide Research
  • Spinal Dysraphism and Malformations
  • Cancer-related gene regulation
  • Plant and animal studies
  • Judicial and Constitutional Studies
  • RNA modifications and cancer
  • Legal principles and applications
  • Epigenetics and DNA Methylation
  • Nerve Injury and Rehabilitation
  • Organoselenium and organotellurium chemistry
  • Nanocluster Synthesis and Applications
  • Orthoptera Research and Taxonomy
  • Environmental and Agricultural Sciences
  • Intellectual Capital and Performance Analysis
  • COVID-19 Digital Contact Tracing
  • Soviet and Russian History
  • Cervical and Thoracic Myelopathy
  • Immune cells in cancer
  • Extracellular vesicles in disease
  • Legal Issues in Education

First Affiliated Hospital of Jinan University
2019-2025

University of Illinois Chicago
2016

Peking University
2011

Jinhua Academy of Agricultural Sciences
2000

Abstract Neuroinflammation is critically involved in the repair of spinal cord injury (SCI), and macrophages associated with inflammation propel degeneration or recovery pathological process. Currently, efforts have been focused on obtaining efficient therapeutic anti‐inflammatory drugs to treat SCI. However, these are still unable penetrate blood barrier lack ability target lesion areas, resulting unsatisfactory clinical efficacy. Herein, a polymer‐based nanodrug delivery system constructed...

10.1002/smll.202102102 article EN Small 2021-09-12

// Yonghua Bao 1, * , Kai Li 2, Yongchen Guo Qian Wang 3 Zexin 4 Yiqiong Yang 1 Zhiguo Chen 5 Jianguo Weixing Zhao Huijuan Zhang Jiwang 6 Huali Dong 7 Kui Shen Alan M. Diamond Wancai Department of Pathology and Institute Precision Medicine, Jining Medical University, 272067, China 2 Pathology, the First Affiliated Hospital, Xinxiang 453003, Immunology, Surgical Oncology, Weihui Division Pulmonary, Critical Care, Sleep Allergy, University Illinois at Chicago, IL 60612, USA These authors have...

10.18632/oncotarget.8511 article EN Oncotarget 2016-03-31

Esophageal cancer is one of the most common cancers worldwide, and incidence mortality increasing rapidly in recent years China, but underlying mechanisms are largely unclear. Herein we found that expression PRSS8, a serine protease prostasin, significantly decreased esophageal squamous cell carcinomas (ESCC) at mRNA protein levels. The reduction PRSS8 was well correlated with poor differentiation shorter survival time. Interestingly, ESCC stromal lymphocyte infiltration progression....

10.18632/oncotarget.8677 article EN Oncotarget 2016-04-11

Background: Anterior cervical discectomy and fusion (ACDF) sacrifices segmental mobility, which can lead to the acceleration of adjacent segment degeneration. The challenge has promoted artificial disc replacement (CADR) as a substitute for ACDF. However, CADR revealed series new issues that are not found in ACDF, such hypermobility, subsidence, wear phenomenon. This study designed subtotal prosthesis (CSDP) consisting structure (CDP structure), vertebra fixation (CVF link structure, locking...

10.3389/fbioe.2021.680769 article EN cc-by Frontiers in Bioengineering and Biotechnology 2021-07-14

<title>Abstract</title> Spinal cord injury (SCI) is a critical condition affecting the central nervous system that often has permanent and debilitating consequences, including secondary injuries. Oxidative damage inflammation are factors in pathological processes. Selenium nanoparticles have demonstrated significant antioxidative anti-inflammatory properties <italic>via</italic> non-immunosuppressive pathway; however, their clinical application been limited by inadequate stability...

10.21203/rs.3.rs-5326730/v1 preprint EN cc-by Research Square (Research Square) 2024-11-06

Benjamin Liebman has written a good article on difficult subject. I have only few comments, divided into three parts. In the first two parts, consider Liebman's approach to such historically complicated matter. think it is appropriate deal with by focusing central question of whether role courts in China's political system changed as result reform; after an initial discussion, show that actually engaged analysis reply question. The third part presents my ideas about different possible tests...

10.1017/s0305741007001622 article EN The China Quarterly 2007-09-01

Nanotherapeutics for Spinal Cord Injury In article number 2102102, Zhizhong Li, Tianfeng Chen, and co-workers design a polymer-based nano drug delivery system conjugating with MMPs-responsive molecule to target the injury site, regulate polarization of macrophages exert neuroprotective effects promote locomotor recovery.

10.1002/smll.202170215 article EN Small 2021-10-01
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