A5034683088- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Selenium in Biological Systems
- RNA Interference and Gene Delivery
- Microtubule and mitosis dynamics
- Immune Cell Function and Interaction
- Cholesterol and Lipid Metabolism
- Immune cells in cancer
- Thyroid Cancer Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Retinal Development and Disorders
- Retinoids in leukemia and cellular processes
- Food Allergy and Anaphylaxis Research
- Cancer-related Molecular Pathways
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Cancer-related molecular mechanisms research
- Pharmacogenetics and Drug Metabolism
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Peroxisome Proliferator-Activated Receptors
First Affiliated Hospital of Jinan University
2023-2025
Wenzhou Medical University
2020-2024
Jinan University
2008-2023
Central South University
2023
Xiangya Hospital Central South University
2023
Affiliated Eye Hospital of Wenzhou Medical College
2020
Easy recurrence and strong treatment side effects significantly limit the clinical of allergic dermatitis. The human trace element selenium (Se) plays essential roles in redox regulation through incorporation into selenoproteins form 21st necessary amino acid selenocysteine, to participates pathogenesis intervention chronic inflammatory diseases. Therefore, based on safe elemental properties Se, we construct a facile-synthesis strategy for antiallergic nanoparticles (LET-SeNPs), scale up...
Low persistence, metabolic dysfunction in microenvironment, and tumor-derived immunosuppression of Natural killer (NK) cells patients are greatly limited the successful clinical application NK cell-based cancer immunotherapy. Interestingly, herein that human serum albumin-encapsulated black phosphorus quantum dots (BPQDs@HSA) can effectively augment antitumor efficacy patients-derived cell immunotherapy is found. As donor phosphate group, BPQDs@HSA binds with protein phosphatidylinositol...
Abstract Glucocorticoid (GC)‐induced osteoporosis (GIO) is a concurrent disease commonly appeared in chronic inflammatory and autoimmune patients. Stereoselective recognition between chiral drugs homochiral biological molecules could directly affect their distribution, adhesion transport. Herein, trace element selenium (Se) with bone formation‐regulating activity, employed to construct cysteine‐decorated nanoparticles (Cys@SeNPs) attenuate GIO. Interestingly, comparing the racemic...
Abstract Autophagy could play suppressing role in cancer therapy by facilitating release of tumor antigens from dying cells and inducing immunogenic cell death (ICD). Therefore, discovery rational design more effective inducers cytotoxic autophagy is expected to develop new strategies for finding innovative drugs precise successful treatment. Herein, we MoO 3‐x nanowires (MoO NWs) with high oxygen vacancy strong photothermal responsivity ablate tumors through hyperthermia, thus promote the...
Abstract Reconstructing the tumor immune microenvironment is an effective strategy to enhance therapeutic efficacy limited by immunosuppression in non‐small‐cell lung cancer (NSCLC). In this study, it found that selenium (Se) depletion and dysfunction are present patients with advanced NSCLC compared healthy volunteers. Surprisingly, Se deficiency resulted decreased immunity accelerated rapid growth mice model, which further reveals correlation between micronutrient progression. This...
The low sensitivity of tumor cells and immunosuppressive microenvironments lead to unsatisfactory efficacy natural killer (NK) cell immunotherapy. In this work, we developed a safe effective combination treatment strategy by integrating selenadiazole derivative (PSeD)-loaded metal azolate framework (PSeD@MAF-4(R)) with NK derived from cancer patients against xenograft human breast model. Intriguingly, it was found that only PSeD@MAF-4(R) pretreatment on exhibited synergistic effects in...
Abstract Autophagy could play suppressing role in cancer therapy by facilitating release of tumor antigens from dying cells and inducing immunogenic cell death (ICD). Therefore, discovery rational design more effective inducers cytotoxic autophagy is expected to develop new strategies for finding innovative drugs precise successful treatment. Herein, we MoO 3‐x nanowires (MoO NWs) with high oxygen vacancy strong photothermal responsivity ablate tumors through hyperthermia, thus promote the...
Abstract Long noncoding RNAs (lncRNAs), a group of transcripts, have been revealed to be critical participants in regulating multiple biological processes malignant tumors. The knowledge NPPA‐AS1 (a new lncRNA) cancer research is hardly known. Thus, it urgent need study the underlying role NPPA antisense RNA 1 (NPPA‐AS1) cervical (CC). In this study, was discovered lowly expressed and upregulation impaired cell proliferation migration CC. Besides, downregulation led opposite results....
The anti-tumor effect of polo-like kinase 4 (PLK4) inhibitor has been explored in several solid carcinomas, while its application anaplastic thyroid cancer (ATC) remains scarce. Hence, the current study aimed to investigate PLK4 on malignant behaviors ATC cell lines and synergistic antitumor with sorafenib. C643 8305c cells were cultured various concentrations centrinone (PLK4 inhibitor) or without Meanwhile, viability, apoptosis, cycle expressions glycogen synthetase beta (GSK3β), p-GSK3β,...
De novo microdeletion of chromosome 2p15-16.1 presents clinically recognizable phenotypes that include mental retardation, autism, and microcephaly. Chromosomal maintenance 1 (CRM1) is a gene commonly missing in patients with one two genes found the smallest deletion case. In this study, we investigate role mechanism Crm1 developing mouse brain by inhibiting protein or knocking down vivo. Inhibition reduces proliferation increases p53-dependent apoptosis cortical neural progenitors, thereby...
OBJECTIVE: To investigate the effects of angiotensin receptor blocker (ARB) on triglyceride (TG) medoxomil metabolism and mechanism thereof. METHODS: Zucker fatty (ZF) rats lean (ZL) were fed with water containing 0.01% olmesartan , a highly specific ARB for 4 weeks. Frequently sampled intravenous glucose tolerance test was conducted to calculate area under (AUCG), insulin sensitivity index (SI), effectiveness (SG), Blood glucose, TC, TG, nonesterified acid (NEFA), HDL-C measured standard...