A5023894248- Liver Disease Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipose Tissue and Metabolism
- Diabetes Management and Research
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Diabetic Foot Ulcer Assessment and Management
- Alcohol Consumption and Health Effects
- Cancer-related molecular mechanisms research
- Wound Healing and Treatments
- Cancer Treatment and Pharmacology
- Chronic Kidney Disease and Diabetes
- Thyroid Disorders and Treatments
- Renin-Angiotensin System Studies
- Parathyroid Disorders and Treatments
- Salivary Gland Disorders and Functions
- Hormonal Regulation and Hypertension
- Neonatal Health and Biochemistry
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Vitamin D Research Studies
Jinan University
2011-2025
Emory University
2023
Guiyang Medical University
2022
Affiliated Hospital of Guizhou Medical University
2022
Red Cross Hospital
2021
First Affiliated Hospital of Jinan University
2021
Showa University
2004-2006
Advanced glycation end products (AGEs) exert divergent effects on the pathogenesis of diabetes complications. Excessive expression matrix metalloproteinases-9 (MMP-9) is deleterious to cutaneous wound-healing process in context diabetes. However, effect AGEs MMP-9 induction skin cells and exact molecular mechanisms involved are still poorly understood. In this study, we investigated production HaCaT keratinocytes characterized signal transduction pathways activated by that regulation. We...
Sedentary behavior is prevalent among people with diabetes and associated unfavorable cardiometabolic health. However, there limited evidence regarding the impact of replacing sedentary time (ST) physical activity on mortality in prediabetes diabetes. We prospectively examined association between accelerometer-measured ST after adjusting for demographic characteristics, lifestyle factors, moderate- to vigorous-intensity PA (MVPA). further determined effect equal different types activities...
Abstract Objective This study investigated the correlation of liver fat content (LFC) with metabolic characteristics and its association chronic complications in type 2 diabetes mellitus (T2DM) patients. Methods Eighty-one prospectively enrolled T2DM patients were divided into non-alcoholic fatty disease (NAFLD) group non-NAFLD according to presence NAFL complications. LFC was determined by MRI IDEAL-IQ Sequence, 4 groups quartile method. Basic information, indexes, occurrence different...
Abstract Background The neutrophil-lymphocyte ratio (NLR) is a novel hematological parameter to assess systemic inflammation. Prior investigations have indicated that an increased NLR may serve as potential marker for pathological states such cancer and atherosclerosis. However, there exists dearth of research investigating the correlation between levels mortality in individuals with diabetes prediabetes. Consequently, this study aims examine connection all-cause well cardiovascular...
The swift transmission rate and unfavorable prognosis associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have prompted the pursuit of more effective therapeutic interventions. Azithromycin (AZM) has garnered significant attention for its distinctive pharmacological mechanisms in treatment SARS-CoV-2. This study aims to elucidate biological rationale employing AZM patients chronic obstructive pulmonary disease (COPD) idiopathic fibrosis (IPF) who are infected Genetic...
Background: Previous research has established a link between high blood levels of parathyroid hormone (PTH) and hyperglycemia, as well early mortality. However, the extent this relationship predictive value PTH for mortality risk in hyperglycemic populations have been minimally explored. Methods: The National Health Nutrition Examination Survey study conducted from 2003 to 2006 identified 932 adults with diabetes 1645 prediabetes. A weighted multivariate logistic regression analysis was...
The effects of angiotensin II type 1 receptor blocker (ARB) on triglyceride (TG) metabolism associated with insulin resistance were explored in Zucker fatty (ZF) rats. Olmesartan medoxomil, a newly developed ARB, was given as 0.01% drinking solution ad libitum to ZF and lean (ZL) rats for 4 wk. lowered blood pressure both strains the same extent. had markedly low sensitivity index (SI) glucose effectiveness (SG), together significantly increased levels. treatment substantially elevated SI...
Platelet dysfunction plays a critical role in vascular complications of type 2 diabetes mellitus (T2DM). But the relationship between platelet hyperactivity and its energy metabolic process remains unclear. This study was designed to explore alterations mitochondrial ATP production possible mechanism. A total 39 T2DM patients without macrovascular microvascular 32 normal controls were fasting sampled. content measured by high performance liquid chromatograph (HPLC). The flow cytometry...
Abstract Background Evidence regarding thyroid-stimulating hormone (TSH) levels within the normal range and mortality in adults with diabetes is scarce. This study aimed to identify association between TSH cardiovascular disease (CVD) all-cause among euthyroid patients diabetes. Methods prospective cohort included 1830 from Third National Health Nutrition Examination Survey III. Mortality outcomes were ascertained by linkage Death Index records through December 31, 2019. Participants...
Abstract Malnutrition significantly hampers wound healing processes. This study aimed to compare the effectiveness of Global Leadership Initiative on (GLIM) and Subjective Assessment (SGA) in diagnosing malnutrition predicting patients with diabetic foot ulcers (DFU). GLIM criteria were evaluated for sensitivity ( S E), specificity (SP), positive predictive value, negative value kappa (κ) against SGA as reference. Modified Poisson regression model DeLong test investigated association between...
LINC00894 plays an important role in cancer cell proliferation and invasion breast kidney cancer. However, its thyroid metastasis remains unclear. In this study, data on expression tissues were obtained from GEPIA2. miRNA was starBase 3.0 OncomiR. Cell evaluated using CCK-8, Transwell chambers used for the migration assays. let-7e-5p expressions cells measured qRT-PCR. Meanwhile, TIA-1 analyzed via western blotting. We found that markedly reduced cells, low of associated with poor prognosis...
•Eribulin combined with anlotinib can significantly improve the PFS of eribulin monotherapy.•Combination therapy group has manageable toxicity similar adverse event spectrum compared monotherapy group.•Circulating tumor DNA aberrations in PIK3CA, ESR1, GATA3 (PEG) were marginally related to higher objective response rate plus group.•Eribulin be considered an alternative treatment option for HER2-negative advanced breast cancer. BackgroundEribulin mesylate is a novel, nontaxane, microtubule...
We recently observed that ANG II receptor blocker therapy improved the overproduction of triglyceride (TG) in fructose-fed rats and Zucker fatty with insulin resistance, which turn suggests may stimulate TG production. Accordingly, we investigated effects on production association resistance normal rats. Male Wistar were continuously infused (100 ng.min(-1).kg body wt(-1)) via an osmotic minipump for 14 days. infusion markedly elevated both systolic diastolic blood pressure. The plasma level...
Aim. Several studies indicated that hyperuricemia may link to the worsening of diabetic nephropathy (DN). Meanwhile, low protein diet (LPD) retards exacerbation renal damage in chronic kidney disease. We then assessed whether LPD influences uric acid metabolism and benefits progression DN streptozotocin- (STZ-) induced rats. Methods. STZ-induced control rats were both fed with (5%) normal (18%), respectively, for 12 weeks. Vital signs, blood urinary samples UA taken analyzed every 3 Kidneys...
Purpose: To investigate the effect of subclinical hypothyroidism on pregnancy outcomes women early in their with different thyroid-stimulating hormone levels and thyroid peroxidase antibody–negative status to explore reasonable for pregnancy. Methods: A total 2378 were studied retrospectively. The baseline characteristics collected from medical records. Pregnancy compared between euthyroidism groups that diagnosed by 2011 or 2017 American Thyroid Association guidelines. In addition, maternal...
We recently reported that chronic angiotensin II (AII) infusion increases plasma triglyceride (TG) levels by stimulating hepatic TG production in rats. To explore this mechanism, we examined the roles of AII type 1 and 2 receptors metabolism same rat model.Normal rats were infused continuously with (100 ng/kg per min) (n = 35) or vehicle (saline, n 15) through an osmotic mini-pump for weeks. The AII-infused given drinking water without 0.01% olmesartan, receptor (AT1R) blocker. markedly...