A5100760721- Nanoplatforms for cancer theranostics
- Redox biology and oxidative stress
- Lanthanide and Transition Metal Complexes
- Metal-Organic Frameworks: Synthesis and Applications
- Selenium in Biological Systems
- Metal complexes synthesis and properties
- Electrocatalysts for Energy Conversion
- Free Radicals and Antioxidants
- Nanocluster Synthesis and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Bacterial biofilms and quorum sensing
- Adenosine and Purinergic Signaling
- Electron Spin Resonance Studies
- Advanced MRI Techniques and Applications
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- Advanced Nanomaterials in Catalysis
- Ga2O3 and related materials
- Medical Imaging Techniques and Applications
- Wound Healing and Treatments
- Trace Elements in Health
- Carbon and Quantum Dots Applications
- Inflammatory Bowel Disease
Jinan University
2020-2025
Second Affiliated Hospital of Zhejiang University
2024-2025
First Affiliated Hospital of Jinan University
2022-2025
University of Electronic Science and Technology of China
2023
Sichuan Cancer Hospital
2023
Johns Hopkins University
2005
Selenoprotein plays a crucial role in immune cells and inflammatory regulation. However, as protein drug that is easily denatured or degraded the acidic environment of stomach, efficient oral delivery selenoprotein great challenge. Herein, we innovated an hydrogel microbeads-based biochemical strategy can situ synthesize selenoproteins, therefore bypassing necessity harsh conditions for while effectively generating selenoproteins therapeutic applications. The microbeads were synthesized by...
Abstract Abnormal expression of transmembrane mucin 16 (MUC16) in ovarian cancer (OC) can promote progression epithelial–mesenchymal transformation, enhance tumor cell proliferation, migration, and invasion. Therefore, herein a targeted therapeutic high‐valence selenium (Se) nanomedicine (MUC16‐SeMnf@Res) is designed, which target MUC16 to recognize OC simultaneously inhibit achieve efficient treatment OC. The valence bidirectional editing strategy used design synthesize Se nanosystem...
Abstract Designing drugs to intelligently respond different ratio of biological electron donors/receptors in cancer cells and normal is a promising strategy achieve highly effective less toxic chemotherapy. Herein by employing metal center active the selenium‐containing electrophilic drug Ru(phtpy‐NO 2 )(phenSe)Cl ( RuSe ) with strongly polarization characteristics are synthesized which can efficiently shuttle electrons from donors convert oxidative stress. The rate transfer at selenium 1.81...
Thioredoxin reductase (TrxR) is highly overexpressed in cancer cells to promote malignant tumor survival. Designing drugs that inhibit TrxR activity a promising approach achieve effective chemotherapy. However, the selectivity of inhibitors continue be challenge for scientists. In this work, we demonstrate new strategy selectively through constructing electrophilic center -N-Se(δ+)-N- by using polarization effect selenium atom. The constructed interacts noncovalently with active motif avoid...
Background: Influenza A (H1N1) virus is an acute respiratory infectious disease that causes massive morbidity and mortality worldwide. As essential trace element, selenium widely applied in the treatment of various diseases because its functions enhancing immune response, antioxidant antiviral mutation. In this study, we constructed selenium-containing metal complex drug delivery system Ru(biim)(PhenSe)2 (RuSe), investigated anti-influenza efficacy potential mechanism for RuSe. Methods: The...
The efficacy of radiotherapy is often significantly compromised due to tumor hypoxia. In this work, we develop a novel strategy overcome hypoxia and enhance by using low-toxicity...
Abstract Background Crohn’s disease (CD) is a chronic inflammatory bowel condition characterized by transmural inflammation that can lead to intestinal fibrosis and strictures. This study aimed investigate the role of Ephrin B2, member ephrin family, in pathogenesis CD-associated fibrosis.The primary objective this was elucidate expression pattern B2 CD explore its potential modulation autophagy AKT/mTOR signaling pathway, which were implicated fibrotic process. Methods The used vivo vitro...
The low sensitivity of tumor cells and immunosuppressive microenvironments lead to unsatisfactory efficacy natural killer (NK) cell immunotherapy. In this work, we developed a safe effective combination treatment strategy by integrating selenadiazole derivative (PSeD)-loaded metal azolate framework (PSeD@MAF-4(R)) with NK derived from cancer patients against xenograft human breast model. Intriguingly, it was found that only PSeD@MAF-4(R) pretreatment on exhibited synergistic effects in...
Abstract Background Henoch-Schönlein purpura (HSP) is a systemic small-vessel vasculitis, and its association with inflammatory bowel disease (IBD) has been the focus of considerable research. Despite numerous studies, it remains uncertain whether in which direction causal relationships exist between HSP IBD. To reveal IBD, we conducted bidirectional two-sample Mendelian randomization analysis using publicly available genome-wide study (GWAS) summary statistics. Methods We obtained...
Bolus followed by constant infusion for tracer administration (B/I) has been used ligand-receptor dynamic PET study to measure changes of binding due neurological or pharmacological stimulation. Concentration ratio (CR) method is commonly quantify the stimulus-induced changes. CR based on assumption that all tissue concentrations are at steady state within a given time period. The objective this develop and evaluate full modeling approach amphetamine-induced potential (BP) in B/I study.