A5023420501- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Selenium in Biological Systems
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanocluster Synthesis and Applications
- Extracellular vesicles in disease
- Metal-Organic Frameworks: Synthesis and Applications
- Bone fractures and treatments
- Carbon and Quantum Dots Applications
- Inflammatory mediators and NSAID effects
- Immune cells in cancer
- Sulfur Compounds in Biology
- Spinal Cord Injury Research
- Heme Oxygenase-1 and Carbon Monoxide
- Bone and Joint Diseases
- Neurological Complications and Syndromes
- Organoselenium and organotellurium chemistry
- Drug-Induced Hepatotoxicity and Protection
- Mesenchymal stem cell research
- MXene and MAX Phase Materials
- Radiation Therapy and Dosimetry
- Knee injuries and reconstruction techniques
- Osteoarthritis Treatment and Mechanisms
- Cholesterol and Lipid Metabolism
- Photoacoustic and Ultrasonic Imaging
Jinan University
2019-2025
First Affiliated Hospital of Jinan University
2018-2025
Union Hospital
2021-2024
Jilin University
2021-2024
Weatherford College
2021
Rational design of potent antioxidative agent with high biocompatibility is urgently needed to treat ischemic reperfusion-induced ROS-mediated cerebrovascular and neural injury during ischemia strokes. Here, we demonstrate an in situ synthetic strategy bioactive zeolitic imidazolate framework-8–capped ceria nanoparticles (CeO2@ZIF-8 NPs) achieve enhanced catalytic activities improved stroke therapeutic efficacy. This nanosystem exhibits prolonged blood circulation time, reduced clearance...
Designing translational antioxidative agents that could scavenge free radicals produced during reperfusion in brain ischemia stroke and alleviate neurologic damage is the main objective for ischemic treatment. Herein, we explored simply synthesized a biomimic Mn3O4 nanoenzyme (HSA-Mn3O4) to constrain reperfusion-induced nervous system injury. This nanosystem exhibits reduced levels of inflammation prolonged circulation time potent ROS scavenging activities. As expected, HSA-Mn3O4 effectively...
Herein, novel multifunctionalized selenium nanoparticles have been rationally designed to reverse oxidative stress-induced spinal cord injury by attenuating ROS overproduction and mitochondria dysfunction<italic>via</italic>inactivation of p53 MAPK pathways.
Abstract Developing radiosensitizers based on the characteristics of tumor microenvironment can improve effectiveness and overcome bottleneck cervical cancer radiotherapy. Herein, an in situ synthesis strategy is demonstrated by using a highly bioactive zeolitic imidazolate framework to cap Mn 3 O 4 folic acid as targeting molecules (FA‐Mn @ZIF‐8) achieve enhanced radiosensitization against cancer. As expected, ZIF‐8 surface responds more effectively X‐rays. Meanwhile, facilitating presence...
Low persistence, metabolic dysfunction in microenvironment, and tumor-derived immunosuppression of Natural killer (NK) cells patients are greatly limited the successful clinical application NK cell-based cancer immunotherapy. Interestingly, herein that human serum albumin-encapsulated black phosphorus quantum dots (BPQDs@HSA) can effectively augment antitumor efficacy patients-derived cell immunotherapy is found. As donor phosphate group, BPQDs@HSA binds with protein phosphatidylinositol...
Abstract Abnormal expression of transmembrane mucin 16 (MUC16) in ovarian cancer (OC) can promote progression epithelial–mesenchymal transformation, enhance tumor cell proliferation, migration, and invasion. Therefore, herein a targeted therapeutic high‐valence selenium (Se) nanomedicine (MUC16‐SeMnf@Res) is designed, which target MUC16 to recognize OC simultaneously inhibit achieve efficient treatment OC. The valence bidirectional editing strategy used design synthesize Se nanosystem...
This study demonstrates the high efficacy of PTR-SeNPs for therapy colorectal cancer and reveals important role autophagy in promoting apoptosis cell cycle arrest to induce death.
Systemic lupus erythematosus (SLE) is characterized by the production of pathogenic autoantibodies, particularly antidouble‐stranded (ds) DNA antibodies, which contribute to multiorgan damage (lupus nephritis, LN). Hence, there an urgent need recognize and eliminate SLE‐specific anti‐ds antibodies enhance SLE treatment. Herein, mesoporous silica (MSNs) loaded with SeC surface‐modified ctDNA are constructed effectively specific bind anti‐dsDNA for treatment in 125 plasm enabling swift LN...
Abstract Reconstructing the tumor immune microenvironment is an effective strategy to enhance therapeutic efficacy limited by immunosuppression in non‐small‐cell lung cancer (NSCLC). In this study, it found that selenium (Se) depletion and dysfunction are present patients with advanced NSCLC compared healthy volunteers. Surprisingly, Se deficiency resulted decreased immunity accelerated rapid growth mice model, which further reveals correlation between micronutrient progression. This...
ABSTRACT Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function vivo. As selenium‐rich organ, the central nervous system can express all 25 kinds of which protect neurons by reducing oxidative stress and inflammatory response. However, decreased Se levels are prevalent variety neurological disorders, not conducive to treatment prognosis patients. Thus, biological study has emerged as focal point investigating pivotal role trace elements...
In the present work, an iridium (Ir) complex loaded theranostic nanoplatform was designed for high-efficiency triple-negative breast cancer (TNBC) therapy. For this purpose, Ir firstly on a photothermal agent of gold nanostars (GNS) by simply mixing followed functionalization using urokinase-type plasminogen activator receptor (uPAR) targeted polyetherimide-AE105 peptide conjugate (P-AE105) with formation GNS@Ir@P-AE105. It demonstrated that resultant GNS@Ir@P-AE105 multifunctional...
Cervical Cancer-Targeting Radiosensitization In article number 2213364, Xueqiong Zhu, Tianfeng Chen, and co-workers report zeolitic imidazolate framework-capped Mn3O4 nanoparticles modified with folic acid X-ray response properties. This nanoparticle possesses a high oxygen vacancies rate Mn3+ ratio, promoting H2O2 glutathione degradation, producing more singlet under X-ray, increasing reactive species level, alleviating hypoxia within the tumor microenvironment. It shows promising potential...
Abstract Rationale: Hoffa fracture is a rare confined to the coronal-plane involving femoral condyles. This occurs simultaneously with rotational dislocation of knee joint extremely rare. Up now, there no valid recommendation for treatment fracture. Patient concerns: A 50-year-old female patient broke her while skiing, experiencing severe pain in right knee, which was swollen. She presented limited function and movement upon arrival emergency room. Diagnosis: Comminuted associated...
Eriodictyol, a flavonoid distributed in citrus fruits, has been known to exhibit anti-inflammatory activity. In this study, destabilized medial meniscus (DMM)-induced OA model was used investigate the protective role of eriodictyol on OA. Meanwhile, we an IL-1β-stimulated human osteoarthritis chondrocytes mechanism The production nitric oxide detected by Griess reaction. productions MMP1, MMP3, and PGE2 were ELISA. expression LXRα, ABCA1, PI3K, AKT, NF-κB measured western blot analysis....
Radioresistance has been the main obstacle of cervical cancer radiotherapy. Hence, it's urgent need to develop effective radiosensitizers for improving radiotherapeutic efficacy. MoSe 2 recognized as a promising therapeutic nanoplatform in radio/photo-mediated therapy, due its narrow bandgap and good photoelectric/photothermal conversion capabilities, while these physical properties biological performance can be various depending on structure. Herein, radiosensitization nanosystems based two...