A5016917968- HIV/AIDS Research and Interventions
- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- HIV Research and Treatment
- Selenium in Biological Systems
- HIV, Drug Use, Sexual Risk
- Robotics and Sensor-Based Localization
- Seaweed-derived Bioactive Compounds
- HIV/AIDS drug development and treatment
- Advanced Vision and Imaging
- HIV-related health complications and treatments
- Hepatitis C virus research
- Protein Hydrolysis and Bioactive Peptides
- Microbial Metabolites in Food Biotechnology
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Polysaccharides Composition and Applications
- Phytochemicals and Antioxidant Activities
- Phytoestrogen effects and research
- Moringa oleifera research and applications
- Adolescent Sexual and Reproductive Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Algal biology and biofuel production
- Food composition and properties
- Nanoplatforms for cancer theranostics
Hong Kong Polytechnic University
2016-2025
Department of Health
2009-2024
Shenzhen Polytechnic
2019-2023
Queen Elizabeth Hospital
2007-2023
Fujian University of Traditional Chinese Medicine
2003-2023
Kaiser Permanente South San Francisco Medical Center
2019-2020
Hospital Authority
2020
Chinese University of Hong Kong
2001-2017
Prince of Wales Hospital
2017
Hung Yen University of Technology and Education
2016
There are inconsistencies in the literature regarding prevalence and assessment of chemotherapy-induced peripheral neuropathy (CIPN). This study explored CIPN natural history its characteristics patients receiving taxane- platinum-based chemotherapy. Multi-country multisite prospective longitudinal observational study. Patients were assessed before commencing three weekly during chemotherapy for up to six cycles, at 6,9, 12 months using clinician-based scales (NCI-CTCAE; WHO-CIPN criterion),...
Dental caries, a highly prevalent oral disease, impacts significant portion of the global population. Conventional approaches that indiscriminately eradicate microbes disrupt natural equilibrium microbiota. In contrast, biointervention strategies aim to restore this balance by introducing beneficial microorganisms or inhibiting cariogenic ones. Over past three decades, microbial preparations have garnered considerable attention in dental research for prevention and treatment caries. However,...
By using mushroom polysaccharides–protein complexes (PSP) as the capping agent, size controllable and highly stable selenium nanoparticles (SeNPs) have been successfully created in a simple redox system of sodium selenite ascorbic acid. SeNPs were capped with PSP through strong physical adsorption hydroxyl groups polysaccharides imino proteins on surface SeNPs. decoration significantly enhanced cellular uptake endocytosis. Treatment PSP–SeNPs inhibited growth MCF-7 human breast cacinoma...
Surface-capping agents play key roles in cellular uptake and biological activity of functional nanomaterials. In the present study, functionalized selenium nanoparticles (SeNPs) have been successfully synthesized using Polyporus rhinocerus water-soluble polysaccharide–protein complexes (PRW) as capping agent during reduction salts. The acquired monodisperse, spherical PRW-SeNPs presented desirable size distribution stability solution. Moreover, PRW surface decoration significantly enhanced...
Herein, we demonstrated a new and facial synthesis of highly uniformed SeNPs using glucose as the reductant surface decorator. Glu–SeNPs induced cancer cell apoptosis<italic>via</italic>induction apoptosis by triggering intracellular ROS overproduction mitochondrial dysfunction.
Selenium nanoparticles (SeNPs) are recently emerging as promising anticancer agents because of their high bioavailability, low toxicity and remarkable activities. However, the effects surface physicochemical properties on biological actions remain elusive. Herein we decorated SeNPs with various water-soluble polysaccharides extracted from mushrooms, to compare physical characteristics profile these SeNPs. The results showed that prepared spherical displayed particle sizes at 91-102 nm, kept...
Ruthenium polypyridyl complexes inhibit cancer growth by targeting TrxR and promote the intracellular ROS generation, ultimately triggering mitochondria-mediated cell apoptosis.
This study demonstrates the high efficacy of PTR-SeNPs for therapy colorectal cancer and reveals important role autophagy in promoting apoptosis cell cycle arrest to induce death.
ABSTRACT In this article, highly stable selenium nanoparticles (SeNPs) were padded onto fabric to obtain, for the first time, antifungal and antibacterial fabric. SeNPs are prepared from a simple food‐grade redox system by using polysaccharide–protein complexes (PSPs) isolated mushroom sclerotia of Pleurotus tuber‐regium (tiger milk mushroom) as modifier or stabilizer. The novel PSP–SeNPs stable, size‐controllable, water‐dispersible. Different amounts applied pad–dry–cure method. It was...
Abstract Owing to the highly malignant and invasive innate character of triple‐negative breast cancers (TNBCs), it is easy relapse after chemotherapy; thus, there are still no effective specific targeted therapies. In this study, a carbon nanotube (CNT)‐based nanosystem Se@CNTs with surface charge flipping ability rationally designed successfully synthesized for precise chemo‐photothermal synergistic therapy TNBCs. The acid‐labile β‐carboxylic acid group used reversibly functionalize amine...
Abstract Using immunofluorescence and neutralization assays, we detected antibodies to human severe acute respiratory syndrome–associated coronavirus (SARS-CoV) and/or animal SARS-CoV–like virus in 17 (1.8%) of 938 adults recruited 2001. This finding suggests that a small proportion healthy persons Hong Kong had been exposed SARS-related viruses at least 2 years before the recent SARS outbreak.
Herein we provide a strategy for facile and large-scale manufacturing of SeNPs with reduced toxicity enhanced anticancer activity <italic>via</italic> oral administration through the regulation surface properties.
Selenium nanoparticles (SeNPs) are a novel elemental form selenium and often reported to possess beneficial bioactivities such as anticancer, promoting bone growth immunomodulation. Our previous study demonstrated that chitosan-stabilized SeNPs have strong activity in However, the mechanism underlying immunomodulation of is still unknown. The aim this identify molecular mechanisms involved SeNP-induced Using zebrafish, common immunological animal model with highly conserved other...