A5100352299- Acupuncture Treatment Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Liver Disease Diagnosis and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Traditional Chinese Medicine Analysis
- Spine and Intervertebral Disc Pathology
- X-ray Diffraction in Crystallography
- Ginseng Biological Effects and Applications
- Neurological disorders and treatments
- Crystallization and Solubility Studies
- Neurological Disease Mechanisms and Treatments
- Sports Performance and Training
- Psychosomatic Disorders and Their Treatments
- Metabolomics and Mass Spectrometry Studies
- Medical Research and Treatments
- Muscle activation and electromyography studies
- Complementary and Alternative Medicine Studies
- Cardiac Fibrosis and Remodeling
- Natural product bioactivities and synthesis
- Neuroscience and Neuropharmacology Research
- Cardiovascular and exercise physiology
- Alcohol Consumption and Health Effects
- Gastrointestinal motility and disorders
- Hereditary Neurological Disorders
Guangzhou University
2022-2025
Guangzhou University of Chinese Medicine
2021-2025
Lanzhou University
2023-2024
Suzhou Municipal Hospital
2024
Nanjing Medical University
2024
Dalian Medical University
2023-2024
First Affiliated Hospital of Dalian Medical University
2023-2024
Binzhou University
2019-2024
Southwest University
2024
Peking University
2008-2024
Importance One of the ordinary manifestations Parkinson disease (PD) is anxiety, which remains untreated. Anxiety closely associated with accelerated progression PD. Efficacy acupuncture for anxiety has been reported. However, to date, there are no data on acupuncture’s effectiveness patients Objective To investigate effect vs sham treating in Design, Setting, and Participants This randomized, double-blinded, clinical trial enrolled between June 20, 2021, February 26, 2022. Final follow-up...
Importance Poor sleep quality greatly impairs of life and accelerates deterioration in patients with Parkinson disease (PD), but current remedies remain limited. Acupuncture, used as an adjunctive therapy anti-Parkinson medications, has shown positive effects PD. However, high-quality clinical evidence to support the effectiveness acupuncture for PD poor is lacking. Objective To assess safety efficacy real (RA) vs sham (SA) who have quality. Design, Setting, Participants This single-center...
Immune checkpoint therapy with PD-1 blockade has emerged as an effective for many advanced cancers; however, only a small fraction of patients achieve durable responses. To date, there is no validated blood-based means predicting the response to blockade. We report that Bim downstream signaling molecule pathway, and its detection in T cells significantly associated expression effector cell markers. High levels circulating tumor-reactive (PD-1+CD11ahiCD8+) were prognostic poor survival...
We have previously demonstrated the anticancer effect of anthocyanins. In this study, we explored biological activities delphinidin, most common anthocyanidin monomers, that were related to autophagy in HER-2 positive breast cancer MDA-MB-453 and BT474 cells. The effects various doses delphinidin on proliferation apoptosis cells analysed. Autophagy was identified as a critical factor influenced chemotherapy, autophagic mechanism delphinidin-treated investigated. inhibitors, 3-MA BA1, used...
The goal of our study was to investigate the heterogeneity cardiac macrophages (CMφs) in mice with transverse aortic constriction (TAC) via single-cell sequencing and identify a subset associated heart injury.We selected all CMφs from CD45+ cells using mRNA data. Through dimension reduction, clustering, enrichment analyses, CD72hi were identified as pro-inflammatory macrophages. pseudo-time trajectory ChIP-Seq analyses Rel key transcription factor that induces CMφ differentiation. KD Rel-/-...
Aging is one of the most prominent risk factors for heart failure. Myeloid-derived suppressor cells (MDSCs) accumulate in aged tissue and have been confirmed to be associated with various aging-related diseases. However, role MDSCs aging remains unknown. Through RNA-seq biochemical approaches, we found that granulocytic (G-MDSCs) accumulated significantly compared monocytic (M-MDSCs). Therefore, explored effects G-MDSCs on heart. We adoptive transfer mice young hearts resulted cardiac...
The relationship between dietary total antioxidant capacity (DTAC) and death risk among CKD populations remains unclear.Based on vitamin C equivalent (VCEAC) the component index (CDAI) indices, we analyzed two cohorts to investigate association of DTAC with all-cause CVD mortality in patients using data from National Health Nutrition Examination Survey (2007-2018). VCEAC (n = 6330) CDAI 6300) follow-up available through 2018 were included. Cox models restricted cubic splines was used model...
Objective To evaluate the efficacy of acupuncture in treating Parkinson’s disease-related constipation (PDC). Materials and methods This was a randomized, controlled trial which patients, outcome assessors, statisticians were all blinded. Seventy-eight eligible patients randomly assigned to either manual (MA) or sham (SA) groups received 12 sessions treatment over 4-week period. Following treatment, monitored until eighth week. The primary change weekly complete spontaneous bowel movements...
Aims: Estrogen plays a protective role in atherosclerosis. Our preliminary work demonstrated that the active conformation of Tanshinone IIA(TanIIA) is similar to 17ß-estradiol and it can bind estrogen receptor. Here, we hypothesized IIA might have anti-inflammatory anti-oxidative effects atherosclerosis, mediated through receptor activation. Methods: Subjects for this study were 120 apoE-/- female mice 20 C57/BL mice. The ovariectomized (OVX) sham ovariectomized. OVX maintained on normal...
Liver fibrosis is a common symptom of non-alcoholic steatohepatitis (NASH) and worldwide clinical issue. The miR-122/HIF-1α signalling pathway believed to play an important role in the genesis progressive fibrosis. Isochlorogenic acid B (ICAB), naturally isolated from Laggera alata, verified have antioxidative hepatoprotective properties. aim this study was investigate effect ICAB on liver NASH its potential protective mechanisms. induced mouse model with methionine- choline-deficient (MCD)...
Background Parkinson’s disease (PD) often necessitates immediate medical intervention following diagnosis. In recent years, there has been a noticeable increase in clinical investigations assessing the efficacy of acupuncture PD, with many studies reporting positive outcomes. Ethical guidelines commonly endorse pharmaceutical therapies for leading ongoing research to combine standard drug-based treatments. At present, is conspicuous absence dedicated exclusively examining independent impact...
In health, most large language model (LLM) research has focused on clinical tasks. However, mobile and wearable devices, which are rarely integrated into such tasks, provide rich, longitudinal data for personal health monitoring. Here we present Personal Health Large Language Model (PH-LLM), fine-tuned from Gemini understanding reasoning over numerical time-series data. We created curated three datasets that test 1) production of personalized insights recommendations sleep patterns, physical...
The paper introduces Professor ZHUANG Lixing's academic thought on Daoqi Tongjing (directing qi to preserve essence) needling technique and the clinical experience. Based Huangdi Neijing (the Yellow Emperor's Inner Classic), Dongyuan JIN Rui 's method, by inheriting valuable experience from ancient masters associating with his own practices, Lixing fully displayes characteristics of principles, methods, formulas, acupoints techniques acupuncture in diagnosis treatment diseases. He integrates...
The incidence of acute ischemic stroke has been rising steadily in China and globally, with its high mortality disability rates significantly affecting quality life. As an important adjunct therapy, acupuncture widely implemented management. Emerging studies have investigated the effects DU meridian Chong Mai on hemiparesis; however, vascular protective mechanisms electroacupuncture therapy targeting these meridians require further elucidation rehabilitation research. This prospective cohort...
Astragalosides (AGs), as one of the main active ingredients in Astragali Radix (AR), have a series biological activities. Previous studies only qualitatively identified metabolites AGs AR, resulting lack quantification. In present study, original material was selected from 12 origins based on levels 4 by high-performance liquid chromatography (HPLC). The prototype components and total (TAGs) feces, urine, plasma samples rats were thoroughly screened characterized ultra-high-performance...
Cervical spondylotic radiculopathy is a common spinal disease. The traditional surgical treatment consists of anterior cervical decompression and fusion (ACDF), but it presents problems such as trauma complications. Percutaneous posterior endoscopic discectomy (PPECD) new minimally invasive technology that has produced good clinical outcome, further biomechanical comparisons are needed to guide the work. goal this study was compare characteristics two methods by finite element analysis. On...
The role of gut-brain axis in the pathogenesis Parkinson’s disease (PD) have become a research hotspot, appropriate animal model to study PD is yet be confirmed. Our employed classical mice achieved by chronic MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) injection concurrent changes dopaminergic neurons midbrain and colon mice. results showed such exhibited apparent locomotor deficits but not gastrointestinal dysfunction. Tyrosine hydroxylase expressions dopamine content reduced...
The use of oral agents that can modify the gut microbiota (GM) could be a novel preventative or therapeutic option for Parkinson's disease (PD). Maslinic acid (MA), pentacyclic triterpene with GM-dependent biological activities when it is taken orally, has not yet been reported to effective against PD. present study found both low and high dose MA treatment significantly prevented dopaminergic neuronal loss in classical chronic PD mouse model by ameliorating motor functions improving...
Ficus pandurata Hance (FPH) is a traditional Chinese herbal medicine, which commonly used for liver protection in the folk of Southeast China. However, medicinal part and pharmacological mechanism have not been clarified yet.This study aims to investigate FPH uncover potential mechanism.Acute alcoholic damage (ALD) mice model induced by intragastric administration with 50% alcohol was evaluate FPH. Different parts FPH, including root (FPHR), stem (FPHS), leaf (FPHL), whole plant (FPHWP),...