A5100752427- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Health and Risk Factors
- Multiple and Secondary Primary Cancers
- Diet and metabolism studies
- Acute Lymphoblastic Leukemia research
- Peripheral Artery Disease Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Dementia and Cognitive Impairment Research
- Neurological disorders and treatments
- Nutritional Studies and Diet
- Drug Solubulity and Delivery Systems
- Acute Myeloid Leukemia Research
- Anorectal Disease Treatments and Outcomes
- Blood transfusion and management
- Advancements in Transdermal Drug Delivery
- Bone and Joint Diseases
- Stroke Rehabilitation and Recovery
- Schizophrenia research and treatment
- Colorectal Cancer Surgical Treatments
- Hepatitis B Virus Studies
- Health and Lifestyle Studies
- Advanced Drug Delivery Systems
Peking University
2018-2025
Zhejiang University
2024-2025
Shaanxi Provincial People's Hospital
2025
Shanxi Medical University
2025
Xi'an Jiaotong University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2024
Chongqing Medical University
2021-2024
Shandong First Medical University
2022-2024
Shandong Provincial Hospital
2022-2024
University of Connecticut
2024
Despite medical advances, there remains an unmet need for better treatment of obesity. Itaconate, a product the decarboxylation tricarboxylic acid cycle intermediate cis-aconitate, plays regulatory role in both metabolism and immunity. Here, we show that itaconate, as endogenous compound, counteracts high-fat-diet (HFD)-induced obesity through leptin-independent mechanisms three mouse models. Specifically, itaconate reduces weight gain, reverses hyperlipidemia, improves glucose tolerance...
Background: The frequency of take-out food consumption has increased rapidly among Chinese college students, which contributed to high obesity prevalence. However, the relationships between consumption, body mass index (BMI), and other individual factors influencing eating behavior students are still unclear. This study explored association with gender, BMI, physical activity, preference for high-fat high-sugar (HFHS) food, major category, degree level students. Methods: Cross-sectional data...
Peripheral arterial disease (PAD) affects approximately 236 million people worldwide. Therefore, this study aimed to investigate the relationship between CYP2C19 genotype polymorphisms and clopidogrel resistance (CR) following revascularization in patients with PAD.
BACKGROUND The surgical management of rectal cancer is continuously advancing, with a current emphasis on minimising the need for permanent stoma. Understanding risk factors influencing sphincter preservation crucial guiding clinical decision-making and optimising preoperative patient evaluation. AIM To examine in laparoscopic radical surgery. METHODS A retrospective analysis demographics, intraoperative data, pathological findings 179 patients who underwent surgery at our hospital between...
Background: A century ago, a mystery between virus and Parkinson's disease (PD) was described. Owing to the limitation of human brain biopsy challenge electron microscopy in observing virions tissue, it has been difficult study viral etiology PD. Recent discovery virobiota reveals that viruses coexist with humans as symbionts. Newly developed transcriptomic sequencing novel bioinformatic approaches for mining encrypted virome transcriptome make possible relationship symbiotic Nevertheless,...
Background This research aims to investigate the relationship between Life’s Essentials 8 (LE8), American Heart Association’s latest indicator, and periodontitis. The purpose is provide guidance on preventative measures. Methods Data for our investigation were obtained from National Health Nutrition Examination Survey (NHANES) 2009–2014, with a total of 8,784 participants eligible. LE8 scores compiled index (the score each component diet, physical activity, nicotine exposure, sleep duration,...
Abstract Immune checkpoint inhibitor (ICI) has reshaped the landscape of cancer therapy and improved prognosis a number malignancies. However, considerable proportion patients fail to benefit from ICI treatment. The main reason for failure is poor infiltration lymphocytes due immunosuppressive milieu that dictates “cold” tumor microenvironment. ubiquitin-proteasome system plays crucial roles in many cellular processes including progression immune evasion. USP25 USP28, two homologous...
The use of oral agents that can modify the gut microbiota (GM) could be a novel preventative or therapeutic option for Parkinson's disease (PD). Maslinic acid (MA), pentacyclic triterpene with GM-dependent biological activities when it is taken orally, has not yet been reported to effective against PD. present study found both low and high dose MA treatment significantly prevented dopaminergic neuronal loss in classical chronic PD mouse model by ameliorating motor functions improving...
Background: Rapidly growing healthcare demand associated with global population aging has spurred the development of new digital tools for assessment cognitive performance in older adults. Objective: To develop a fully automated Mini-Mental State Examination (MMSE) model and validate model’s rating consistency. Methods: The Automated Assessment Model MMSE (AAM-MMSE) was an about 10-min computerized screening tool containing same questions as traditional paper-based Chinese MMSE. validity...
Introduction Diabetic foot ulcer (DFU) stands as a severe diabetic lower extremity complication, characterized by high amputation rates, mortality, and economic burden. We propose using Mendelian randomization studies to explore shared distinct risk factors for complications. Research design methods selected uncorrelated genetic variants associated with 85 phenotypes in five categories at the genome-wide significance level instrumental variables. Genetic associations DFU, polyneuropathy...
The increasing prevalence of obesity has resulted in demands for the development new effective strategies treatment. Withaferin A (WA) shows a great potential prevention by sensitizing leptin signaling hypothalamus. However, mechanism underlying weight- and adiposity-reducing effects WA remains to be elucidated. In this study, we report that treatment induced white adipose tissue (WAT) browning, elevated energy expenditure, decreased respiratory exchange ratio, prevented high-fat...
Abstract The RII β subunit of cAMP‐dependent protein kinase A (PKA) is expressed in the brain and adipose tissue. ‐knockout mice show leanness increased UCP1 brown authors have previously reported that reexpression hypothalamic GABAergic neurons rescues leanness. However, whether white tissue (WAT) browning contributes to ‐PKA these governs WAT are unknown. Here, this work reports ‐KO exhibit a robust browning. dorsal median (DMH neurons) abrogates Single‐cell sequencing, transcriptome...
Abstract Background: A century ago, a mystery between virus and Parkinson’s disease (PD) was described. Owing to the limitation of human brain biopsy challenge electron microscopy in observing virions tissue, it has been difficult study viral etiology PD. Recent discovery virobiota reveals that viruses coexist with humans as symbionts. Newly-developed transcriptomic sequencing novel bioinformatic approaches for mining encrypted virome transcriptome make possible relationship symbiotic...
Abstract The cyclic-AMP dependent protein kinase A (Protein A, PKA) regulates dopaminergic function in the substantia nigra pars compacta (SNc). However, whether PKA is involved pathogenesis of Parkinson’s disease (PD) unknown. Here, by collecting and analyzing current worldwide SNc transcriptomic datasets PD patients, we found a decline PKA-RIIβ subunit level patients. decreased was positively correlated with dopamine synthesis increased oxidative stress expressed striatum SNc. gene...
BACKGROUND Laparoscopic anatomical liver resection has become more challenging because some subsegmental Glissonean pedicles are hard to dissect. Here, we introduce how dissect every (sub) segmental pedicle from the first porta hepatis and perform standardized segmentectomy [from segment 1 (S1) S8]. AIM To summarize our methods of laparoscopic resection. METHODS The Glisson sheath capsule were separated along Laennec membrane. could be isolated transected with little or no parenchymal damage...
Abstract Background Triple-negative breast cancer (TNBC) has pronounced stemness that is associated with relapse. N 6 -methyladenosine (m A) plays a crucial role in shaping cellular behavior by modulating transcript expression. However, the of m A TNBC stemness, as well mechanisms governing its abundance, yet to be elucidated. Methods We analyzed proteomic and transcriptomic data derived from cohorts, an emphasis on regulators. To unravel TNBC, we employed RNA sequencing, methylated...