A5039551773- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- Natural product bioactivities and synthesis
- Toxin Mechanisms and Immunotoxins
- Connexins and lens biology
- Liver physiology and pathology
- Metabolism, Diabetes, and Cancer
- Peptidase Inhibition and Analysis
- Flavonoids in Medical Research
- Advanced Glycation End Products research
- Phytochemistry and Biological Activities
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plants and Bioactive Compounds
- FOXO transcription factor regulation
- Ginseng Biological Effects and Applications
- Photosynthetic Processes and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Virus-based gene therapy research
China Pharmaceutical University
2014-2025
Affiliated Hospital of Hangzhou Normal University
2025
Chengdu Medical College
2018-2022
The University of Queensland
2021
Zhejiang Hisun Pharmaceutical (China)
2017
Liuyang City Maternal and Child Health Hospital
2015
National Yang Ming University Hospital
2014
Boston Children's Hospital
2014
National Yang Ming Chiao Tung University
2014
Nanyang Medical College
2011
Abstract Pancreatic adenocarcinoma (PDA) is one of the most lethal human malignancies and unresponsive to current chemotherapies. Here we investigate therapeutic potential phycocyanin as an anti-PDA agent in vivo vitro . Phycocyanin, a natural product purified from Spirulina, effectively inhibits pancreatic cancer cell proliferation xenograft tumor growth Phycocyanin induces G2/M cycle arrest, apoptotic autophagic death PANC-1 cells. Inhibition autophagy by targeting Beclin 1 using siRNA...
We have previously demonstrated the anticancer effect of anthocyanins. In this study, we explored biological activities delphinidin, most common anthocyanidin monomers, that were related to autophagy in HER-2 positive breast cancer MDA-MB-453 and BT474 cells. The effects various doses delphinidin on proliferation apoptosis cells analysed. Autophagy was identified as a critical factor influenced chemotherapy, autophagic mechanism delphinidin-treated investigated. inhibitors, 3-MA BA1, used...
The mechanism of C-PC in improving glucose homoeostasis is to activate the IRS/PI3 K/Akt and SIRT1/LKB1/AMPK signaling pathway insulin resistant hepatocytes.
Context: Phycocyanin (PC) has been proven to have many therapeutic properties, but its effects on diabetes not investigated.Objective: Antidiabetic activity of PC isolated from Spirulina platensis was evaluated in this study.Materials and methods: Oral administration (100 mg/kg, once per day for 3 weeks) KKAy mice were investigated by monitoring the changes body weight, food intake, fasting plasma glucose level, 24 h random blood levels, oral tolerance tests (OGTTs), glycosylated serum...
G protein-coupled receptors (GPCRs) are important potential drug targets for the treatment of metabolic disorders. The D2 dopamine receptor (DRD2), a GPCR receptor, is member family. However, role DRD2 in regulating lipid metabolism, especially hepatic steatosis, unclear. Eight-week male mice were fed HFHC/MCD to induce MASH model. AAV2/8 containing TBG promoter was used knock down and overexpress mouse liver. Co-immunoprecipitation, Western lotting, immunofluorescence, immunohistochemistry...
ABSTRACT The accurate diagnosis of tumors is crucial for improving treatment outcomes. To precisely delineate the nucleus regions tumor cells in hematoxylin and eosin (H&E) stained tissue images reduce computational overhead, we propose a novel encoder‐decoder architecture named Convolution focused linear attention fusion UNet (CLA‐UNet), which integrates depthwise separable convolution convolution‐focused into U‐Net network. innovation this study reflected following three aspects:...
Introduction Poultry production remains an important aspect of food systems because it provides supplementary income and a cheap source protein. Backyard has been growing lately due to many factors like urbanization, population increase, increases in levels at household levels. However, there is paucity information on the characteristics backyard broiler Zambia. Methods This study using structured online questionnaire was administered 444 respondents all 10 provinces Zambia provide...
Hedgehog signaling pathway plays a critical role in the initiation and development of pancreatic ductal adenocarcinoma (PDA) represents an attractive target for PDA treatment. Lithium, clinical mood stabilizer mental disorders, potently inhibits activity glycogen synthase kinase 3β (GSK3β) that promotes ubiquitin-dependent proteasome degradation GLI1, important downstream component hedgehog signaling. Herein, we report lithium cell proliferation, blocks G1/S cell-cycle progression, induces...
Methylglyoxal (MG) is a reactive dicarbonyl compound, whose abnormal accumulation in diabetic patients exerts deleterious effects on cells and tissues. The β-cell the main target cell of Type 2 diabetes, its insulin secretion injury apoptosis can be due to mitochondrial dysfunction. Previous studies have demonstrated MG induced apoptosis. However, little known about effect Phycocyanin (PC) has been possess various biological activities including models vivo. aim this study was determine...
The emergence of NDM-1 containing multi-antibiotic resistant "Superbugs" necessitates the needs developing novel NDM-1inhibitors. In this study, we report discovery inhibitors by multi-step virtual screening. From a 2,800,000 drug-like compound library selected from ZINC database, generated focused inhibitor 298 compounds which 44 chemical were purchased and evaluated experimentally for their ability to inhibit in vitro. Three with micromolar IC50 values validated. most potent inhibitor,...
The present study aims to investigate the pharmacological effect of exopolysaccharides from Aphanothece halophytica GR02 (EPSAH) on HeLa human cervical cancer cell line. cells were cultured in RPMI-1640-10% FBS medium containing with or without different concentrations EPSAH. Cell viability was assessed by methylthiazol tetrazolium (MTT) assay. apoptosis elevated Wright-Giemsa staining, AO/EB double and DNA fragmentation Apoptosis-associated molecules quantified using Western blot analysis....
Delphinidin is an anthocyanidin monomer, commonly found in vegetables and fruits, has demonstrated antitumor effects the HER-2-positive MDA-MB-453 breast cancer cell line, with low cytotoxicity on normal cells. However, direct functional mechanisms underlying effect of delphinidin cells not been fully characterized. In present study, it was that could induce G2/M phase cycle arrest by inhibiting protein expression level cyclin B1 Cdk1 lines. addition, promoted mitochondrial apoptosis pathway...
The lacto-ghrestatin derived nonapeptide (LGP9), a bioactive peptide from in bovine milk with the sequence of LIVTQTMKG, was investigated to determine its effects on islet β-cell dedifferentiation and associated mechanisms type 2 diabetes mellitus (T2DM). On animal level, type-2-diabetic (T2D) mice were generated by high-fat-diet (HFD) streptozocin (STZ). LGP9 given T2D for four weeks at doses 1 mg kg-1, 3 9 kg-1. A variety techniques (immunohistochemistry, western blot, QPCR, ELISA)...