A5006929447- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Temporomandibular Joint Disorders
- Orthodontics and Dentofacial Orthopedics
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Prion Diseases and Protein Misfolding
- Anesthesia and Sedative Agents
- Inflammation biomarkers and pathways
- Memory and Neural Mechanisms
- Dental materials and restorations
- Hydrocarbon exploration and reservoir analysis
- Porphyrin and Phthalocyanine Chemistry
- Mesoporous Materials and Catalysis
- Catalytic C–H Functionalization Methods
- Seed and Plant Biochemistry
- Nonlinear Optical Materials Studies
- Cancer, Lipids, and Metabolism
- Nonlinear Optical Materials Research
- Liver Disease Diagnosis and Treatment
- Hydraulic Fracturing and Reservoir Analysis
- Advanced Algebra and Geometry
- Peroxisome Proliferator-Activated Receptors
- COVID-19 Clinical Research Studies
- Pregnancy and Medication Impact
Chongqing Three Gorges University
2019-2025
China Pharmaceutical University
2025
TEDA International Cardiovascular Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Guangdong Medical College
2002-2024
Leshan Normal University
2024
Zhejiang Chinese Medical University
2023-2024
Xijing Hospital
2024
Air Force Medical University
2024
Research Institute of Petroleum Exploration and Development
2020-2024
How ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) lower plasma lipid levels is incompletely understood. We previously showed that marine PUFAs (docosahexaenoic acid [DHA] eicosapentaenoic acid) stimulate a novel pathway, post-ER presecretory proteolysis (PERPP), degrades apolipoprotein B100 (ApoB100), thereby reducing lipoprotein secretion from liver cells. To identify signals stimulating PERPP, we examined known actions of PUFA. In rat hepatoma or primary rodent hepatocytes incubated with...
Abstract Singlet oxygen ( 1 O 2 ) has a potent anticancer effect, but photosensitized generation of is inhibited by tumor hypoxia and limited light penetration depth. Despite the potential chemodynamic therapy (CDT) to circumvent these issues exploration ‐producing catalysts, engineering efficient CDT agents still formidable challenge since most catalysts require specific pH function become inactivated upon chelation glutathione (GSH). Herein, we present catalytic microenvironment‐tailored...
The impact of posterior tooth loss on the temporomandibular joint (TMJ) is controversial. Existing studies mainly rely clinical observation, lacking biomechanical research. This study recruited 10 healthy volunteers (Control group) and 20 patients with (PTL group). Three-dimensional maxillofacial models were reconstructed. Finite element analysis showed stress concentration in PTL group, magnitudes much higher than Control especially tooth-missing side. Posterior causes asymmetric TMJ...
G protein-coupled receptors (GPCRs) are important potential drug targets for the treatment of metabolic disorders. The D2 dopamine receptor (DRD2), a GPCR receptor, is member family. However, role DRD2 in regulating lipid metabolism, especially hepatic steatosis, unclear. Eight-week male mice were fed HFHC/MCD to induce MASH model. AAV2/8 containing TBG promoter was used knock down and overexpress mouse liver. Co-immunoprecipitation, Western lotting, immunofluorescence, immunohistochemistry...
Insulin-resistant apoB/BATless mice have hypertriglyceridemia because of increased assembly and secretion very low density apolipoprotein B (apoB) triglycerides compared with expressing only apoB (Siri, P., Candela, N., Ko, C., Zhang, Y., Eusufzai, S., Ginsberg, H. Huang, L. S. (2001) J. Biol. Chem. 276, 46064-46072). Despite lipoprotein secretion, fatty livers. We found that hepatic mRNA levels key lipogenic enzymes, acetyl-CoA carboxylase, fatty-acid synthase, stearoyl-CoA desaturase-1...
The SnO<sub>2</sub>@graphene nanocomposite shows an enhanced sensing response to HCHO, suggesting it is effective material for formaldehyde detection.
Fluoride is capable of inducing developmental neurotoxicity, yet its mechanisms remain elusive. We aimed to explore the possible role and mechanism autophagic flux blockage caused by abnormal lysosomal pH in fluoride-induced focusing on V-ATPase regulating neuronal pH. Using Sprague-Dawley rats exposed sodium fluoride (NaF) from gestation through delivery until neonatal offspring reached six months age as an vivo model. The results showed that NaF impaired cognitive abilities rats. In...
The in vivo effects of increased delivery fatty acids (FA) to the liver are poorly defined. Therefore, we compared infusing either 6 mM oleic acid (OA) bound albumin, 0.5-20% Intralipid, or saline for 3 h into male C57BL/6J mice. Infusions were followed by studies triglyceride (TG) and apoB secretion. Although plasma FA levels similarly after 20% Intralipid OA, TG secretion only infusion 4-20% Intralipid; was unchanged OA. By contrast, 6-h infusions OA each from primary hepatocytes ex vivo....
The aim of this study was to evaluate stress distributions in the temporomandibular joints (TMJs) with disorders (TMDs) for comparison healthy TMJs. A model mandible and normal TMJs developed according CT images. interfaces between discs articular cartilages were treated as contact elements. Nonlinear cable elements used simulate disc attachments. Based on model, seven models various TMDs established. maximum stresses anterior, posterior, medial lateral displacement (ADD, PDD, MDD LDD)...
The aim of this study is to compare the differences in stress distributions temporomandibular joints (TMJs) patients with facial asymmetry before and after bilateral sagittal split ramus osteotomy (BSSRO) under symmetric occlusions using three-dimensional (3D) finite element method.Ten (Preoperative group, age 24.6 ± 4.8 years) 10 asymptomatic subjects (Control 26.8 4.9 were recruited. After underwent BSSRO, they further assigned as Postoperative group. 3D geometries models mandible, disc,...
Contacts used in finite element (FE) models were considered as the best simulation for interactions temporomandibular joint (TMJ). However, precision of simulations should be validated through experiments. Three-dimensional (3D) printing with high geometric and loading similarities individuals validation. This study aimed to validate FE TMJ using 3D models. Five asymptomatic subjects recruited this study. mandible, disc, maxilla reconstructed according cone-beam CT (CBCT) image data. PLA was...
Objective: Patient-derived xenograft (PDX) models have shown great promise in preclinical and translational applications, but theirconsistency with primary tumors phenotypic, genetic, pharmacodynamic heterogeneity has not been well-studied. This studyaimed to establish a PDX repository for non-small cell lung cancer (NSCLC) further elucidate whether it could preserve theheterogeneity within between patients. Methods: A total of 75 surgically resected NSCLC specimens were implanted into...