A5089684709- Fluoride Effects and Removal
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Drug-Induced Hepatotoxicity and Protection
- Autophagy in Disease and Therapy
- Bacterial biofilms and quorum sensing
- Nanoparticles: synthesis and applications
- Traditional Chinese Medicine Analysis
- Tea Polyphenols and Effects
- Antimicrobial Peptides and Activities
- Microbial infections and disease research
- Inflammation biomarkers and pathways
- Drug Transport and Resistance Mechanisms
- Antibiotic Resistance in Bacteria
- Anesthesia and Neurotoxicity Research
- Pharmacological Effects of Natural Compounds
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Biochemical and Structural Characterization
- Tryptophan and brain disorders
- Biomarkers in Disease Mechanisms
- Healthcare and Venom Research
- Veterinary medicine and infectious diseases
- Metabolomics and Mass Spectrometry Studies
- Medicinal Plants and Neuroprotection
Tianjin People's Hospital
2024-2025
Sichuan Agricultural University
2015-2024
Tianjin Medical University
2023-2024
Second Hospital of Tianjin Medical University
2023-2024
Sichuan University
2022
Chengde Medical University
2020
Chengdu University
2018
Sichuan Animal Science Academy
2018
In-Q-Tel
2018
Southwest University
2013
Copper (Cu) is an essential trace element involved in the normal physiological processes of animals. However, excessive exposure to Cu can produce numerous detrimental impacts. The aim this study was investigate effects on oxidative stress and apoptosis as well their relationship mouse liver. Four-week-old ICR mice (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>240</mml:mn></mml:math>) were randomly assigned different...
The current study was conducted to investigate the effect of sodium fluoride (NaF) on oxidative stress and apoptosis as well their relationship in mouse liver by using methods flow cytometry, quantitative realtime polymerase chain reaction (qRT-PCR), western blot, biochemistry experimental pathology.240 fourweek-old ICR mice were randomly divided into 4 groups exposed different concentration NaF (0 mg/kg, 12 24 mg/kg 48 mg/kg) for a period 42 days.The results showed that caused...
Although nano-copper is currently used extensively, the adverse effects on liver cytochrome P450 (CYP450) enzymes after oral exposure are not clear. In this study, we determined and mechanisms of action nano- micro-copper expression activity CYP450 in rat liver. Rats were orally exposed to (400 mg/kg), Cu ion (100 or (100, 200 400 mg/kg) daily for seven consecutive days. Histopathological, inflammatory oxidative stress measured livers all rats. The mRNA levels enzymes, as well select nuclear...
Research has shown that nano-copper (nano-Cu) can cause damage to the spleen and immune system yet their mechanisms of cytotoxicity are poorly understood. Our aim is explore potential immunotoxicity in rats after nano-Cu exposure. The results hematologic parameters, lymphocyte subsets, immunoglobulins, histopathology indicated copper obviously changed function spleen. levels antioxidants (SOD, CAT, GSH-Px), oxidants (iNOS, NO, MDA), anti-oxidative signalling pathway Nrf2 (Nrf2 HO-1) were...
At present, there are few studies focused on the relationship between copper (Cu) and oxidative stress, apoptosis, or inflammatory responses in animal human lungs. This study was conducted to explore effects of Cu pulmonary apoptosis mice orally administered with 0 mg/kg (control), 10 mg/kg, 20 40 CuSO4 for 42 days. The results showed that increased ROS production, MDA, 8-OHdG NO contents as well iNOS activities mRNA expression levels. Meanwhile, reduced levels antioxidant enzymes (GSH-Px,...
With the prevalence of multidrug-resistant bacteria and clinical -acquired pathogenic infections, development quorum-sensing (QS) interfering agents is one most potential strategies to combat bacterial infections antibiotic resistance. Chinese herbal medicines constitute a valuable bank resources for identification QS inhibitors. Accordingly, in this research, some compounds were tested inhibition using indicator strains. Paeonol phenolic compound, which can effectively reduce production...
Nano-copper has been increasingly employed in various products. In previous studies, we showed that nano-copper caused damage the rat testis, but it remains unclear whether toxic reaction can affect reproductive function. this study, following 28 d of exposure to at a dose 44, 88, and 175 mg/kg/day, there was decrease sperm quality, fructose content, secretion sex hormones. also increased level oxidative stress, malformation rate, induced abnormal structural changes testicular tissue....
Pseudomonas aeruginosa (P. aeruginosa), one of the dangerous multidrug resistance pathogens, orchestrates virulence factors production through quorum sensing (QS). Since exploration QS inhibitors, targeting to circumvent bacterial pathogenesis without causing significant growth inhibition is a promising approach treat P. infections. The present study has evaluated anti-QS and anti-infective activity epigallocatechin-3-gallate (EGCG), bioactive ingredient traditional green tea, against...
Early studies have shown that the gut microbiota is a critical target during cadmium exposure. The prebiotic activity of epigallocatechin-3-gallate (EGCG) plays an essential role in treating intestinal inflammation and damage. However, exact barrier protection mechanism EGCG against exposure remains unclear. In this experiment, four-week-old mice were exposed to (5 mg kg
<title>Abstract</title> <bold>Objective</bold> observe the healthy liver cholesterol-lowering pills for methionine choline lack of feed (Methionine-choline deficient，MCD) diet induced nonalcoholic fatty hepatitis (Nonalcoholic steatohepatitis，NASH) mechanism lipid metabolism and inflammation in mice. <bold>Methods </bold>The mice were randomly divided into control group, model positive drug low, medium high dose groups Jianganjiangzhi pills, 10 each group.The group ate normal diet, other...
Fluoride is widely distributed in the environment and often results adverse health effects on animals human beings. It has been proved that fluoride can induce inflammatory responses vitro. However, very limited reports are focused fluoride-induced vivo. In this study, mice were used to investigate sodium (NaF) induced renal potential mechanism by using methods of pathology, biochemistry, enzyme-linked immunosorbent assay (ELISA), quantitative real-time polymerase chain reaction (qRT-PCR)...
// Qin Luo 1 , Hengmin Cui 1,2 Huidan Deng Ping Kuang Huan Liu Yujiao Lu Jing Fang Zhicai Zuo Junliang Yinglun Li Xun Wang and Ling Zhao College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, China 2 Key Laboratory Animal Diseases Environmental Hazards Province, Agriculture Correspondence to: Cui, email: Keywords : sodium fluoride, oxidative damage, lesion, dysfunction, kidney, Immunology Microbiology Section, Immune response, Immunity Received March 13, 2017...
The widespread use of nano-copper as a feed additive in the absence toxicological studies has potential risks to humans and animals. Toxicity on animals usually exposure from respiratory tract, however, it is necessary study oral toxicity understand its additive. Currently hepatotoxicity mechanism after sub-choronic at equivalent doses 50, 100, 200 mg/kg/day were evaluated rats; micro-copper Cu ions used controls. Nano-copper (200 mg/kg) increased serum alanine aminotransferase aspartate...
Nickel (Ni), an environmental hazard, widely causes allergic contact hypersensitivity worldwide.Despite that Ni-stimulated pro-inflammatory response is vital in allergy, the underlying molecular mechanisms remain largely unclear.Here, we demonstrated NiCl2 activated nuclear factor kappa B (NF-κB), mitogenactivated protein kinases (MAPKs) and interferon regulatory 3 (IRF3) signaling pathways primary bone marrow-derived macrophages (BMDMs), leading to altered transcription levels of...
Abstract Background Breast cancer is the most common malignancy in women, and it also leading cause of death female patients; pathological type BC infiltrating duct carcinoma (IDC). Some nomograms have been developed to predict bone metastasis (BM) patients with breast cancer. However, there are no studies on diagnostic prognostic for BM newly diagnosed IDC patients. Methods from 2010 2016 Surveillance, Epidemiology End Results (SEER) database were reviewed. Multivariate logistic regression...