A5011270539- Animal Virus Infections Studies
- Herpesvirus Infections and Treatments
- Viral Infections and Immunology Research
- Aquaculture disease management and microbiota
- Selenium in Biological Systems
- Trace Elements in Health
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Virus-based gene therapy research
- Phytoestrogen effects and research
- Parkinson's Disease Mechanisms and Treatments
- Animal Nutrition and Physiology
- Heavy Metal Exposure and Toxicity
- Cytomegalovirus and herpesvirus research
- Polysaccharides and Plant Cell Walls
- Animal Disease Management and Epidemiology
- Mycotoxins in Agriculture and Food
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Toxin Mechanisms and Immunotoxins
- Adipose Tissue and Metabolism
Sichuan Agricultural University
2016-2025
First Affiliated Hospital of Hebei Medical University
2020-2024
Hebei Medical University
2020-2024
Beijing Tongren Hospital
2022
Capital Medical University
2022
Second Military Medical University
2016-2021
Chengdu University
2018
Zhejiang Cancer Hospital
2017
Changhai Hospital
2016
Maternal and Child Health Hospital of Sichuan Province
2010
Abstract A comprehensive transcriptomic survey of pigs can provide a mechanistic understanding tissue specialization processes underlying economically valuable traits and accelerate their use as biomedical model. Here we characterize four transcript types (lncRNAs, TUCPs, miRNAs, circRNAs) protein-coding genes in 31 adult pig tissues two cell lines. We uncover the variability among 47 skeletal muscles, six adipose depots linked to different origins, metabolism, composition, physical...
The aim of this study was to investigate the possible protective role sodium selenite on aflatoxin B1-induced oxidative stress and apoptosis in spleen broilers. Two hundred one-day-old male broilers, divided into five groups, were fed with basal diet (control group), 0.3 mg/kg AFB1 (AFB1 + 0.2 Se (+Se group I), 0.4 II) 0.6 III), respectively. According biochemical assays, significantly decreased activities glutathione peroxidase, total superoxide dismutase, reductase, catalase level hormone,...
The purpose of the present study was to investigate oxidative damage and apoptosis induced by aflatoxin B 1 (AFB ) in spleen broilers. A total 200 one-day-old avian male broilers were randomly divided into 4 equal groups 50 each fed for 21 days as follows: a control diet three AFB diets containing 0.15, 0.3, 0.6 mg /kg diet. Consumption stress chicken evidenced reduced glutathione peroxidase, reductase, catalase activities, decreased contents, increased malondialdehyde contents explaining...
Background: The damage to intestinal barrier function plays an important role in the development of obesity and associated diseases. Soy isoflavones are effective natural active components for controlling reducing level blood lipid. Here, we explored whether these effects soy were with function. Methods Results: obese rat models established by high fat diet feeding. Then, those rats supplemented at different doses 4 weeks. Our results showed that induced expressions pro-inflammatory...
Aflatoxin B1 is known as a mycotoxin that develops various health problems of animals, the effects AFB1 on thymus and bursa Fabricius in chickens are not clear. The objective this study was to investigate apoptosis broilers fed with . Two hundred Avian were randomly divided into four groups 50 each, namely control group three 0.15 mg, 0.3 0.6 mg /kg diet, respectively. In study, flow cytometer immunohistochemical approaches used determine percentage apoptotic cells expression Bax, Bcl-2,...
Hepatic oxidative stress, as one important mechanism of cadmium (Cd)-induced hepatic toxicity, could, known, be ameliorated by vitamin E (VE). However, the underlying remains to elucidated. To investigate whether antioxidant can protect against Cd-induced sub-chronic liver injury associated with stress and nuclear factor erythrocyte 2-related 2 (Nrf2) pathway, male Sprague-Dawley rats (nine-week-old) were randomly divided into four groups (eight rats/group), namely, control, VE (100 mg/kg...
Despite decades of research into the pathology mechanisms Parkinson's disease (PD), disease-modifying therapy PD is scarce.Thus, searching for new drugs or more effective neurosurgical treatments has elicited much interest.Clioquinol (CQ) been shown to have therapeutic benefits in rodent models neurodegenerative disorders.However, it's neuroprotective role and primate patients, especially advanced stages, are not fully understood.Furthermore, issues such as spontaneous recovery motor...
<b><i>Background/Aims:</i></b> The aminolycoside Gentamicin is a widely used antibiotic, applied in equine medicine. Despite its clinical use, concerns remain regarding the potential toxic side-effects, such as nephrotoxicity. Early detection of renal damage critical preclinical drug development. This study was aimed to determine whether kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) may be early indicators assessment...
We conducted a systematic review and meta-analysis of observational case-control studies to evaluate markers oxidative stress in seminal plasma patients with male infertility.Current evidence links infertility, which multiple have been widely detected, publishing inconsistent results regard the role evaluation infertility. Therefore, on this issue is necessary.From 1024 articles initially retrieved, 65 were included our 11 markers, containing 3819 infertility 2012 controls. The...
This study was conducted to investigate the effects of aflatoxin B1 (AFB1) on T-cell subsets and mRNA expression cytokines in small intestine broilers. One hundred fifty-six one-day-old healthy Cobb broilers were randomly divided into control group (0 mg/kg AFB1) AFB1 (0.6 with three replicates per 26 birds replicate for 21 days, respectively. At 7, 14, days age, duodenum, jejunum ileum sampled analyzing T cell (CD3+, CD3+CD4+ CD3+CD8+) by flow cytometry as well IL-2, IL-4, IL-6, IL-10,...
The high recurrence frequency of gliomas but deficiency effective treatment and prevalent chemoresistance have elicited interests in exploring developing new agents. Paris polyphyllins are monomers extracted from rhizome polyphylla var. yunnanensis. Here, we first reported that polyphyllin VII (PP7) exhibited cytotoxic effect on glioma cells. PP7 significantly suppressed the viability induced cell death U87-MG U251 cells after 24 h, with IC50 values <mml:math...
Nickel (Ni), a widely distributed metal, is an important pollutant in the environment. Although kidney crucial target of Ni toxicity, information on autophagy and potential mechanisms Ni-induced renal toxicity are still poorly described. As we discovered, NiCl2 could induce damage including decrease weight, histological alterations, function injury. According to obtained results, obviously increase autophagy, which was characterized by LC3 expression p62 expression. Meanwhile, result...
Colon cancer is a common malignant tumor of the digestive tract, and it considered among biggest killers. Scientific reasonable treatments can effectively improve survival rate patients if performed in early stages. Polyphyllin I (PPI), pennogenyl saponin isolated from Paris polyphylla var. yunnanensis, has exhibited strong anti-cancer activities previous studies. Here, we report that PPI exhibits cytotoxic effect on colon cells. suppressed cell viability induced autophagic death SW480 cells...