A5048955337- Polysaccharides and Plant Cell Walls
- Fungal Biology and Applications
- Ginseng Biological Effects and Applications
- Polysaccharides Composition and Applications
- Seaweed-derived Bioactive Compounds
- Microbial Metabolites in Food Biotechnology
- Plant-based Medicinal Research
- Atrial Fibrillation Management and Outcomes
- Phytochemistry and Biological Activities
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Cardiovascular Health and Risk Factors
- Moringa oleifera research and applications
- Cardiovascular Disease and Adiposity
- Ginger and Zingiberaceae research
- RNA Interference and Gene Delivery
- Phytochemical Studies and Bioactivities
- Berberine and alkaloids research
- Natural product bioactivities and synthesis
- Mitochondrial Function and Pathology
- Nanoplatforms for cancer theranostics
- Pharmaceutical and Antibiotic Environmental Impacts
Xinxiang Medical University
2019-2025
Sichuan Agricultural University
2016-2024
Fudan University
2022-2024
Nanjing University of Chinese Medicine
2022-2024
Nanjing Drum Tower Hospital
2022-2024
Zhongshan Hospital
2022-2024
Central South University
2024
Fujian Agriculture and Forestry University
2024
Third Xiangya Hospital
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Based on previous studies about microflora regulation and immunity enhancement activities of polysaccharides from Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen (CPP), there is little study intestinal mucosal immunity, which a possible medium for contacting immunity. In the present study, BALB/c mice were divided into five groups (eight in each group), including normal group (Con), model control (Model), that administered CPP (50, 100, 200 mg/kg/d) orally day seven days after...
Roots of Aconitum carmichaelii are used in Asian countries due to its content bioactive alkaloids. In the production root preparations, tons leaves usually discarded, leading a huge waste herbal material. The aim this study is investigate polysaccharides these unutilized leaves. A neutral polysaccharide (AL-N) appeared be mixture heteromannans, and two purified acidic (AL-I-I AL-I-II) were shown pectins containing homogalacturonan backbone substituted with terminal β-Xylp-units. AL-I-I...
Metastasis leads to the vast majority of breast cancer mortality. Increasing evidence has shown that N6-methyladenosine (m6A) modification and its associated regulators play a pivotal role in metastasis. Here, we showed overexpression m6A reader IGF2BP1 was clinically correlated with metastasis patients. Moreover, promoted distant vitro vivo. Mechanistically, first identified USP10 as deubiquitinase. can bind to, deubiquitinate, stabilize IGF2BP1, resulting higher expression level cancer....
The industrial processing of Aconitum carmichaelii roots for use in Traditional Chinese Medicine generates a high amount waste material, especially leaves. An acidic polysaccharide fraction isolated from these unutilized leaves, AL-I, was our previous work shown to contain pectic polysaccharides. This study aimed investigate the protective effect AL-I on ulcerative colitis possible application A. leaves treatment intestinal inflammatory diseases. found alleviate symptoms and colonic...
To analyze the imaging and clinical features of fetal cardiac tumors, to explore relationship between tuberous sclerosis complex (TSC) rhabdomyoma in fetus.Fifty-three women pregnant with a fetus affected by tumor(s) were examined standardized echocardiography (FE), fetuses, mothers fathers, including other relevant family members if necessary, underwent familial TSC genetic testing. Relevant pathological features, findings at examination liveborn infants autopsy terminated cases, noted.Of...
In this study, an acidic polysaccharide from Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen (WCP-I) and its main fragment, WCP-Ia, obtained after pectinase digestion, were structurally elucidated found to consist of a rhamnogalacturonan I (RG-I) region containing both arabinogalactan type (AG-I) II (AG-II) as sidechains. They expressed immunomodulating activity against Peyer’s patch cells. Endo-1,4-β-galactanase degradation gave decrease interleukine 6 (IL-6) production compared...
Epigallocatechin gallate (EGCG) has been regarded as a protective bioactive polyphenol in green tea against nonalcoholic steatohepatitis (NASH), but the mechanism remains poorly deciphered. Herein, we assessed role and of EGCG on gut microbiota metabolism NASH development. Forty-eight male C57BL/6J mice were fed with either methionine-choline-sufficient diet or methionine-choline-deficient (MCD) without administration for 4 weeks. Liver injury, inflammation, lipid accumulation, iron overload...
Aging is a biological process that leads to the progressive deterioration and loss of physiological functions in human body results an increase morbidity mortality, aging-related disease major global problem poses serious threat public health. Polysaccharides have been shown delay aging by reducing oxidative damage, suppressing inflammatory responses, modulating intestinal microbiota. Our previous studies polysaccharide CPP-1 extracted from root Codonopsis pilosula possesses noticeable...
Aging is a biological process of progressive deterioration physiological functions, which poses serious threat to individual health and heavy burden on public systems. As population aging continues, research into anti-aging drugs that prolong life improve particular importance. In this study, the polysaccharide from stems leaves Chuanminshen violaceum was obtained with water extraction alcohol precipitation, then separated purified DEAE anion exchange chromatography gel filtration obtain...
Background Posttranslational modifications of histone lysine (K) have integral connections with cell metabolism, and participate in the carcinogenesis various cancers. This study focuses on evaluating expression H4 lys 5 lactylation (H4K5lac) its clinical role breast cancer (BC). Methods During this research, immunohistochemistry (IHC) immunoblotting, utilizing a specific primary anti-L-lactyl-histone (Lys 5) rabbit monoclonal antibody, were employed to assess H4K5lac BC tissue chips....
The prepared magnetic nanoparticles wrapped in bacterial membranes can promote immunogenic cell death and recruit immune cells to kill tumors.
Abstract Atrial fibrillation (AF) is an increasingly prevalent arrhythmia with significant health and socioeconomic impact. The underlying mechanism of AF still not well understood. In this study, we sought to identify hub genes involved in AF, explored their functions mechanisms based on bioinformatics analysis. Five microarray datasets GEO were used the differentially expressed (DEGs) by Robust Rank Aggregation (RRA), screened out using protein–protein interaction (PPI) network. model was...
Abstract Necroptosis, a novel programmed cell death, plays critical role in the development of fibrosis, yet its atrial fibrillation (AF) remains elusive. Mounting evidence demonstrates that aerobic exercise improves AF‐related symptoms and quality life. Therefore, we explored necroptosis AF pathogenesis exercise‐conferred cardioprotection. A mouse model was established either by calcium chloride acetylcholine (CaCl 2 ‐Ach) administration for 3 weeks or high‐fat diet (HFD) feeding 12 weeks,...
An inulin (CPPF), isolated from a traditional Chinese herbal medicine Codonopsis pilosula, was characterized and demonstrated with potential prebiotic activity in vitro before. Based on its non-digested feature, the intestinal mucosa microbiota modulatory effects vivo immunosuppressed mice were investigated after oral administration of 200, 100 50 mg/kg CPPF for 7 days. It that secretions sIgA mucin 2 (Muc2) ileum improved by CPPF, anti-inflammatory activities different intestine parts...