A5075209123- Gut microbiota and health
- Probiotics and Fermented Foods
- Animal Nutrition and Physiology
- Clostridium difficile and Clostridium perfringens research
- Fluoride Effects and Removal
- Antimicrobial Peptides and Activities
- Aquaculture disease management and microbiota
- Viral gastroenteritis research and epidemiology
- Pharmacological Effects of Natural Compounds
- Oral microbiology and periodontitis research
- Rabbits: Nutrition, Reproduction, Health
- Bacteriophages and microbial interactions
- Gout, Hyperuricemia, Uric Acid
- Diet and metabolism studies
- Animal Virus Infections Studies
- Tryptophan and brain disorders
- Barrier Structure and Function Studies
- Protein Hydrolysis and Bioactive Peptides
- Anesthesia and Neurotoxicity Research
- Molecular Biology Techniques and Applications
- Genomics and Phylogenetic Studies
- Bone and Dental Protein Studies
- Biochemical effects in animals
- Liver Disease Diagnosis and Treatment
- Moringa oleifera research and applications
Sichuan Agricultural University
2016-2025
Ministry of Education of the People's Republic of China
2023
Jinan University
2019
Along with banning of antibiotics, necrotic enteritis (NE), especially subclinical NE (SNE) whereby no clinical signs are present in chicks, has become one the most threatening problems poultry industry. Therefore, increasing attention been focused on research and application effective probiotic strains, as an alternative to prevent SNE broilers. In study, we evaluated effects Lactobacillus johnsonii BS15 prevention Specifically, assessment determined growth performance indexes related...
Necrotic enteritis (NE) is a severe intestinal disease, which can change gut microbiota and result in high cost for the poultry industry worldwide. However, little known regarding how of NE chicken ileum are changed by Bacillus licheniformis. This study was conducted to investigate structure B. licheniformis broiler chickens challenged with Clostridium perfringens-induced through Illumina MiSeq sequencing. The broilers were randomly separated into four groups: negative control group (NC),...
Clostridium perfringens can induce necrotic enteritis of chickens, which causes large economic losses every year. Bacillus licheniformis, a probiotic, inhibit the growth pathogenic bacteria such as perfringens, thereby improving health status chickens. However, from microbial ecology perspective, mechanisms by alterations to gut microbiota improve remain unknown. In this study, we used Illumina MiSeq sequencing investigate cecal negative control group (NC), C. and Eimeria challenge with...
Chinese Mongolian sheep are an important ruminant raised for wool and meat production. However, little is known about the microbiota of gastrointestinal tract (GIT) sheep. To increase our understanding microbial community composition in GIT sheep, five investigate first time using Illumina MiSeq platform. High diversity was obtained from GIT, exhibited a higher biodiversity stomach large intestine than small intestine. Firmicutes (44.62%), Bacteroidetes (38.49%), Proteobacteria (4.11%) were...
Fluoride is a common contaminant of groundwater and agricultural commodity, which poses challenges to animal human health. A wealth research has demonstrated its detrimental effects on intestinal mucosal integrity; however, the underlying mechanisms remain obscure. This study aimed investigate role cytoskeleton in fluoride-induced barrier dysfunction. After sodium fluoride (NaF) treatment cultured Caco-2 cells, both cytotoxicity cytomorphological changes (internal vacuoles or massive...
Nickel (Ni) is an important and widely hazardous chemical industrial waste. Excessive Ni exposure could cause multi-organs toxicity in human animals. Liver the major target organ of accumulation toxicity, however, precise mechanism still unclear. In this study, nickel chloride (NiCl2 )-treatment induced hepatic histopathological changes mice, and, transmission electron microscopy results showed mitochondrial swollen deformed hepatocyte. Next, damages including biogenesis, dynamics, mitophagy...
Background Hyperuricemia (HUA) is a prevalent metabolic disorder whose development associated with intestinal microbiota. Therefore, probiotics have emerged as potential and safe approach for lowering uric acid (UA) levels. However, the underlying mechanisms of many effective probiotic strains remain unknown. Methods results C57BL/6 mice were randomly divided into two groups: control model groups. The group received 12 weeks potassium oxonate. Through 16s sequencing we found that HUA...
Examples of probiotics that can promote host health by improving its intestinal microbial balance and immunity belong to the genus Lactobacillus. Bursin (BS) is a peptide isolated from bursa Fabricius for use as an adjuvant variety immunogens. To investigate synergistic effects Lactobacillus plantarum (LP) dietary supplementation BS immunization on production performance, immune characteristics, antioxidant status, microflora in broilers, we randomly allocated 200 1-day-old broilers mixed...
The probiotic strain Lactobacillus johnsonii BS15 could exert beneficial effects on growth performance, lipid metabolism, and intestinal microflora in healthy broilers those afflicted with subclinical necrotic enteritis (SNE). In particular, prevents SNE by enhancing immunity. To further understand the immune regulatory mechanism of BS15, we evaluated its overall immunity determining blood parameters broilers. this study, two experiments were conducted. Experiment 1 involved a 42-day...
Though the underlying mechanism remains elusive, a close relationship between psychological stress and intestinal inflammation has been widely accepted. Such link is very important to set basis for our understanding of critical role gut-brain axis (GBA) in homeostatic processes health disease. Probiotics that could confer benefits mental through GBA are referred as “psychobiotics”. This study aimed further determine whether potential psychobiotic strain, Lactobacillus johnsonii BS15 prevent...
Introduction In recent years, a large number of studies have shown that Bacillus velezensis has the potential as an animal feed additive, and its probiotic properties been gradually explored. Methods this study, Illumina NovaSeq PE150 Oxford Nanopore ONT sequencing platforms were used to sequence genome TS5, fiber-degrading strain isolated from Tibetan sheep. To further investigate B. TS5 strain, in vivo experiments conducted using 40 five-week-old male specific pathogen-free C57BL/6J mice....
Bacillus subtilis, a probiotic bacterium with engineering potential, is widely used for the expression of exogenous proteins. In this study, we utilized integrative plasmid pDG364 to integrate hemagglutinin–neuraminidase (HN) gene from Newcastle disease virus (NDV) into genome B. subtilis 168 model strain. We successfully constructed recombinant strain (designated RH) that displays truncated HN antigen fragment on surface its spores and further evaluated immunogenic effects in mice. Using...
Abstract Brevibacillus laterosporus is a strain of probiotic bacteria that has been widely used in pest control, cash crop, and other production areas. However, few studies have conducted on its use as feed additive animals. Therefore, the potential B. PBC01 was evaluated by characterizing hydrophobicity, auto‐aggregation activity, bile salt simulated gastrointestinal fluid tolerance, bienzymatic, antibacterial activity. Antibiotic susceptibility, hemolysis assays, supplemental feeding mice...
To assess the potential of essential oils and structurally related synthetic food additives in inhibiting growth Clostridium perfringens for control necrotic enteritis chickens.The antimicrobial activity oils/compounds was measured by determining inhibition bacterial growth. Thirty-three 66 exhibited > or =80% inhibition. Seven with highest potency were further studied. The had MIC(95) values between 167 425 microg ml(-1). Most them tolerant to low pH (2.0) minor no Lactobacillus isolates...
To determine whether Lactobacillus johnsonii BS15 supplementation improves the growth performance and meat quality of broilers, 450 1-day-old male chicks (Cobb 500) were randomly divided into three groups: control group (basal corn-soybean diet), L-BS15 diet + 1 × 105 colony-forming unit BS15/g as feed), H-BS15 106 feed). These diets fed for 42 days. Abdominal fat decreased (P < 0.05) concentration increased. significantly increased pH at 24 h after sacrifice drip loss shearing force...
Researchers are attempting to harness the advantages of gut–brain axis prevent neurocognitive disorders by enhancing intestinal health. In this study, four groups ICR mice were orally gavaged with either phosphate buffered saline (control and CW groups) or probiotic strain Lactobacillus johnsonii BS15 (P PW group; daily amounts 2×108 colony-forming units) for 28 days. From day 22 28, in subjected water avoidance stress (WAS). The issue whether psychological stress-induced memory dysfunction...
Fluoride which is widespread in our environment and food due to its geological origin industrial pollution has been identified as a developmental neurotoxicant. Gut-brain axis provides new insight into brain-derived injury. We previously found the psychoactive effects of probiotic strain, Lactobacillus johnsonii BS15 against fluoride-induced memory dysfunction mice by modulating gut-brain axis. In this study, we aimed detect link between reconstruction gut microbiota through alleviate...