A5100448425- Gut microbiota and health
- Influenza Virus Research Studies
- Clostridium difficile and Clostridium perfringens research
- Air Quality and Health Impacts
- Atmospheric chemistry and aerosols
- Immune Response and Inflammation
- Diet and metabolism studies
- Parasites and Host Interactions
- Probiotics and Fermented Foods
- Global Maternal and Child Health
- Animal Disease Management and Epidemiology
- COVID-19 epidemiological studies
- Land Rights and Reforms
- Animal Virus Infections Studies
- Sepsis Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Inflammatory Bowel Disease
- Tryptophan and brain disorders
- Vitamin D Research Studies
- Hydrogen's biological and therapeutic effects
- Liver Disease Diagnosis and Treatment
- Air Quality Monitoring and Forecasting
- Thyroid Disorders and Treatments
- Microbial metabolism and enzyme function
- Seaweed-derived Bioactive Compounds
Huashan Hospital
2024-2025
Fudan University
2014-2025
Guangdong Ocean University
2022-2025
Foshan University
2025
Comprehensive Clinical Research
2024
Zhongnan Hospital of Wuhan University
2021-2024
Wuhan University
2021-2024
Shanghai Jiao Tong University
2022-2024
Renji Hospital
2024
Sichuan Agricultural University
2023
Gut dysbiosis and oxidative stress may trigger senile osteoporosis. Fructus Ligustri Lucidi (FLL) has bone-preserving properties affects the intestinal microecology. However, mechanism of anti-osteoporotic effect FLL its link to gut microbiota remains be elucidated. Here, we demonstrated that sustained exposure ICR mice D-galactose / sodium nitrite for 90 days causes aging-related osteoporosis reduced cognitive performance. The aging phenotype is also characterized by increased in serum....
Background. Of all intestinal microbiome-derived metabolites, trimethylamine N-oxide (TMAO) has received increasing attention because of its potent role in colorectal cancer development. Accumulating evidence suggests that TMAO generated by the gut microbiota is a new and important player etiological process cancer. Nevertheless, carcinogenic mechanism remains unclear. In this study, induced cell proliferation produced higher vascular endothelial growth factor A (VEGFA) levels vitro. vivo,...
The microbial community performs vital functions in the intestinal system of animals. Modulation gut microbiota structure can indirectly or directly affect health and host metabolism. Aohan fine-wool sheep grow semi-desert grasslands China show excellent stress tolerance. In this study, we amplified 16S rRNA gene to investigate dynamic distribution adaptability microbiome duodenum, jejunum, ileum, cecum, colon, rectum seven at 12 months. results showed that composition diversity ileum large...
Certain antibiotics detected in urine are associated with childhood obesity. In the current experimental study, we investigated two representative urine, florfenicol and azithromycin, for their early effects on adipogenesis, gut microbiota, short-chain fatty acids (SCFAs), bile mice. Thirty C57BL/6 mice aged four weeks were randomly divided into three groups (florfenicol, azithromycin control). The administered or at 5 mg/kg/day weeks. Body weight was measured weekly. composition of body...
Abstract. We developed a two-stage model called the random-forest–generalised additive (RF–GAM), based on satellite data, meteorological factors, and other geographical covariates, to predict surface 8 h O3 concentrations across remote Tibetan Plateau. The 10-fold cross-validation result suggested that RF–GAM showed excellent performance, with highest R2 value (0.76) lowest root-mean-square error (RMSE) (14.41 µg m−3), compared seven machine-learning models. predictive performance of...
Microbiome research based on high-throughput sequencing has grown exponentially in recent years, but methodological variations can easily undermine the reproducibility across studies. To systematically evaluate comparability of results 16S rRNA gene (16Ss)- and shotgun metagenomic (SMs)-based microbial community profiling laboratories under routine conditions. We designed a multicenter study 35 participating China using mock communities homogenized fecal samples. A wide range practices...
Abstract. The rapid response to the COVID-19 pandemic led unprecedented decreases in economic activities, thereby reducing pollutant emissions. A random forest (RF) model was applied determine respective contributions of meteorology and anthropogenic emissions changes air quality. result suggested that strict lockdown measures significantly decreased primary components such as Cr (−67 %) Fe (−61 PM2.5 (p<0.01), whereas higher relative humidity (RH) NH3 level lower temperature (T)...
Despite its high mortality, specific and effective drugs for sepsis are lacking. Decoy receptor 3 (DcR3) is a potential biomarker the progression of inflammatory diseases. The recombinant human DcR3-Fc chimera protein (DcR3.Fc) suppresses responses in mice with sepsis, which critical improving survival. Fc region can exert detrimental effects on patient, endogenous peptides highly conducive to clinical application. However, mechanisms underlying DcR3 unknown. Herein, we aimed demonstrate...
Introduction Carrageenan oligosaccharides are of significant interest due to their diverse bioactivities, necessitating efficient methods for production. To this day, the discovery and isolation microorganisms capable effectively degrading carrageenan is still crucial production oligosaccharides. In addition, there no current reports bacteria genus Photobacterium secreting κ-carrageenanase or carrageenan. Methods study, strain GDSX-4 was obtained from Gracilaria coronopifolia after...
Objectives The present study was conducted to reappraise the prognostic value of decoy receptor 3 (DcR3) for patients with sepsis and septic shock according latest Sepsis-3 definitions. Methods Subjects suffering from or were enrolled within 6 h admission. Sequential Organ Failure Assessment (SOFA) score plasma levels DcR3, C-reactive protein, procalcitonin, interleukin-6 measured. Group comparisons made based on survival status day 28 after onset. Predictors mortality assessed using Cox...
The enzyme/protein immobilized monolithic capillary combined with liquid chromatography-mass spectrometry is an efficient screening strategy for the corresponding agonist/antagonist. LasR potential therapeutic target since it plays a vital role in colonization and invasion of Pseudomonas aeruginosa (P. aeruginosa). Therefore, reagents that inhibit may be effective against P. aeruginosa. To screen find inhibitors rapidly, LasR-immobilized column was prepared characterized. Firstly,...
Gut microbiota is closely related to age. Studies from Europe and the U.S. identified featured in different age groups for elderly. Asian studies mainly focused on people living longevity areas. Featured elderly of groups, especially centenarian general population, has not been well investigated China.We conducted a comparative study by including 198 subjects three (65-70, 90-99, 100+ years) East China. Information regarding age, sex, height, weight, waist circumference, hip food preference,...
Novel avian influenza viruses (AIVs) of H7N9, H10N8, and H5N6 are currently circulating in China's poultry flocks, occasionally infecting human other mammals. Human infected AIV China during 2014–2015 is believed to be a triple reassortant originated from H6N6 two clades H5 viruses. The current report suggests that its reassortment history more complicated. Genomes isolates were searched the NCBI Influenza Virus Sequence Database Global Initiative on Sharing Avian Data. Sequences shared high...
Schistosomiasis remains a major public health problem and causes substantial economic impact in east China, particularly along the Yangtze River Basin. Disease forecasting surveillance can assist development implementation of more effective intervention measures to control disease. In this study, we applied Bayesian hierarchical spatio-temporal model describe trends schistosomiasis risk Anhui Province, using annual parasitological environmental data for period 1997-2010. A computationally...
Abstract No effective method has been developed to distinguish sperm cells originating from different men in multi-suspect sexual assault cases. Here we combined MACS and FACS isolate single donor forensic mixture samples including female vaginal epithelial multiple contributors. Sperms swab were isolated by using FITC-conjugated A kinase anchor protein 3 (AKAP3) antibody; target individual involving two or three donors separated FITC-labeled blood group A/B antigen antibody. This procedure...
Objectives: Although the association between thyroid stimulating hormone (TSH) and obesity in children has been investigated several cross-sectional studies, no study evaluated this among girls during puberty, which were a key period closely related to fluctuations of hormones development obesity. Therefore, we conducted cohort investigate general abdominal with TSH puberty. Setting participants: A 481 school-aged puberty was conduct four cities East Coast China, baseline survey 2017...
Objective: Cirrhosis and other chronic liver diseases (generally referred to as cirrhosis in this article) are major causes of morbidity mortality China. The disease pattern caused by different etiologies has been changing due economic development changes lifestyle. Methods: Prevalence, incidence, disability-adjusted life-years, data were retrieved from the Global Burden Disease study, 2019. Estimated annual percentage change was used quantify trends age-standardized prevalence rate number...
Abstract Atherosclerosis (AS) is associated with high morbidity and mortality, thus imposing a growing burden on modern society. Herb‐derived bicyclol (BIC) versatile bioactive compound that can be used to treat AS. However, its efficacy in AS not yet described. Here, it shown BIC normalizes gut microflora dysbiosis induced by fat diet Apoe (−/−) mice. Metagenome‐wide association study analysis verifies the modulation carbohydrate‐active enzymes short‐chain fatty acid generating genes flora...
Background: Inflammatory bowel disease (IBD) is a global gastrointestinal characterized by relapsing and remitting inflammatory conditions. Flos Puerariae (the flower of Pueraria lobata [Willd.] Ohwi P. thomsonii Benth.) Hovenia dulcis Thunb. (Rhamnaceae) are traditional Chinese medicines. This medicinal pair has been used to treat various diseases due its excellent anti-oxidant anti-inflammatory activity. However, the effects extracts from these plants on dextran sulfate sodium...