A5101667379- Seaweed-derived Bioactive Compounds
- Natural Compounds in Disease Treatment
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Gastrointestinal motility and disorders
- Microbial Natural Products and Biosynthesis
- Polysaccharides and Plant Cell Walls
- Cytokine Signaling Pathways and Interactions
- Fungal Biology and Applications
- Pharmacological Effects of Natural Compounds
- NF-κB Signaling Pathways
- Rheumatoid Arthritis Research and Therapies
- Gut microbiota and health
- interferon and immune responses
- RNA modifications and cancer
- MicroRNA in disease regulation
- Synthesis and biological activity
- Bioinformatics and Genomic Networks
- Autoimmune and Inflammatory Disorders Research
- Bone Metabolism and Diseases
- Cutaneous lymphoproliferative disorders research
- Parasites and Host Interactions
- Microbial Community Ecology and Physiology
- Systemic Lupus Erythematosus Research
- Clostridium difficile and Clostridium perfringens research
Fujian Medical University
2019-2025
First Affiliated Hospital of Fujian Medical University
2019-2025
Fudan University
2024
Chinese PLA General Hospital
2023-2024
Nankai University
2023-2024
Xi'an Jiaotong University
2017-2023
Shanghai Veterinary Research Institute
2021-2023
Chinese Academy of Agricultural Sciences
2021-2023
Ministry of Agriculture and Rural Affairs
2023
Hunan University
2023
Triptolide (TP), an active component isolated from Tripterygiumwilfordii Hook F, has therapeutic potential against rheumatoid arthritis (RA). However, the underlying molecular mechanism not been fully elucidated. The aim of this study is to investigate mechanisms TP acting on RA by combining bioinformatics analysis with experiment validation. human protein targets and genes were found in PubChem database NCBI, respectively. These two dataset then imported into Ingenuity Pathway Analysis...
Anxiety and depression are complications in Irritable bowel syndrome (IBS) patients. In this study, we recruited 18 IBS patients with mild-modest anxiety behaviors, after the screening, defined FMT treatment group (n = 9) control 9). The symptom severity scale (IBS-SSS), Hamilton Rating Scale (HAM-A), Depression (HAM-D), Bowel Syndrome Quality of Life (IBS-QOL) Bristol stool (BSS) were evaluated one week before (baseline), one-week-, one-month-, two-month-, three-month-following FMT....
MicroRNAs (miRNAs) have been explored in many critical cellular processes, including proliferation and apoptosis. The purpose of this study was to detect the biological function regulation miR-99b-5p miR-203a-3p gastric cancer (GC). Here, we demonstrated that miR-99b-5p/203a-3p were downregulated both GC tissues cell lines. MiR-99b-5p/203a-3p overexpression reduced cycle progression vitro. Notably, combined bioinformatics tools with validation assays demonstrate insulin-like growth factor 1...
Purpose: This study aimed to explore underlying action mechanism of Wu-Tou decoction (WTD) in rheumatoid arthritis (RA) through network pharmacology prediction and experimental verification. Methods: Chemical compounds human target proteins WTD as well RA-related genes were obtained from TCM Database @ Taiwan, PubChem GenBank, respectively. Subsequently, molecular networks canonical pathways presumably involved the treatment on RA generated by ingenuity pathway analysis (IPA) software....
This study investigated the clinical characteristics and dynamic changes of intestinal bacterial community to evaluate curative effect fecal microbiota transplantation (FMT) on irritable bowel syndrome with predominant diarrhea (IBS-D) comorbid anxiety depression. Total two treatments were designed in randomize-controlled trial includes oral FMT capsules 1 week (A1), 8 weeks (A2), 12 (A3), as well empty (B1), (B2), (B3) control for comparison. The positive therapeutic effects occurred...
Objectives The present study was conducted to reappraise the prognostic value of decoy receptor 3 (DcR3) for patients with sepsis and septic shock according latest Sepsis-3 definitions. Methods Subjects suffering from or were enrolled within 6 h admission. Sequential Organ Failure Assessment (SOFA) score plasma levels DcR3, C-reactive protein, procalcitonin, interleukin-6 measured. Group comparisons made based on survival status day 28 after onset. Predictors mortality assessed using Cox...
Yupingfeng San (YPFS) is a representative Traditional Chinese Medicine (TCM) formula with accepted therapeutic effect on Asthma. However, its action mechanism still obscure. In this study, we used network pharmacology to explore potential of YPFS asthma. Nucleotide-bindling oligomerization domain (NOD)-like receptor pathway was shown be the top one shared signaling associated both and addition, NOD-like family pyrin domain-containing 3 (NLRP3) inflammasome treated as target protein in...
Euglena is a new super health food resource that rich in the natural polysaccharide paramylon, linear β-1,3-glucan with various biological activities including activity on immune system different cell lines and animals. Despite these reports, regulation mechanism of paramylon still unclear.
Abstract BACKGROUND D‐psicose is a rare sugar and exists in extremely small quantities nature. It has important physiological functions allowed to be used as an ingredient foods dietary supplements. The aim of this study develop the biotransformation, separation purification methods for highly efficient mass production d‐psicose. RESULTS First, gene d‐psicose 3‐epimerase (DPE) from Ruminococcus sp. was cloned overexpressed food‐grade microorganism Bacillus pumilus , recombinant protein...
Hepatocellular carcinoma (HCC), one of the most common aggressive tumors worldwide has a relatively high mortality rate among malignant tumors. MicroRNAs (miRNAs), acting as tumor suppressors, are involved in regulation invasion, metastasis, and angiogenesis cells. However, potential role for miR-203a HCC not been described yet. In this study, we show that markedly suppresses cell migration, angiogenesis. addition, transcription factor HOXD3 appears to be direct target miR-203a. knockdown...
Necrotizing enterocolitis (NEC) is a life-threatening disease for premature infants with low body weight. Due to its fragile gut microbiome and successful treatment of fecal microbiota transplantation (FMT) intestinal disease, we aimed reveal the multiple-omics changes after FMT and/or sulperazone treatment. In this study, 2-week-old newborn rabbits were used simulate NEC model grouped into healthy control, NEC, treatment, FTM combination We evaluated pathology survival define benefit from...
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by infiltrating inflammatory cells and demyelinating lesions, T helper (Th) play critical roles in pathogenesis MS. There still lack effective treatments currently. Pien Tze Huang (PZH), a traditional Chinese medicine formula, has been proved to have anti-inflammatory, neuroprotective, immunoregulatory effects. However, whether PZH can be used treat MS obscure. This study aimed investigate...
Gastric cancer (GC), one of the most common malignant tumors and second leading cause cancer-related death worldwide, is a biologically heterogeneous disease accompanied by various genetic epigenetic alterations. However, molecular mechanisms underlying this are complex not completely understood. Increasing studies have shown that aberrant microRNA (miRNA) expression associated with GC tumorigenesis growth. MiR-1297 has been confirmed to be suppressor in diverse humans. date, function...
<bold>G03</bold> is a novel anticancer agent with unusual microtubule-stabilizing effects.
We have recently reported computational models for prediction of cell-based anticancer activity using machine learning methods.
Triptolide (TPL) is a diterpenoid triepoxide derived from the Chinese herb Tripterygium wilfordii and possesses anti-tumor activity against range of cancer cells.However, effect TPL on prostate cells its potential to overcome multidrug resistance (MDR) have not been explored.Therefore, in this study we used cell line DU145 as experimental model established DU145/ADM resistant adriamycin (ADM).Our results showed that inhibited proliferation induced cycle arrest apoptosis dose time dependent...
Rheumatoid arthritis (RA) is a type of chronic systemic inflammatory disease; it has very complicated pathogenesis, and multiple pathological changes are implicated. Traditional Chinese medicine (TCM) like Tripterygium wilfordii Hook. F. or Sinomenium acutum (Thunb.) Rehd et Wils. been extensively used for centuries in the treatment arthritic diseases reported effective relieving severity RA. Hei-Gu-Teng Zhuifenghuoluo granule (HGT) which contains Periploca forrestii Schltr. , Wils.,...
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). There still lack commercially viable treatment currently. Pien Tze Huang (PZH), traditional Chinese medicine, has been proved to have anti-inflammatory, neuroprotective, and immunoregulatory effects. This study investigated possible therapeutic effects PZH on experimental autoimmune encephalomyelitis (EAE) rats, classic animal model MS. Male Lewis rats were immunized with myelin basic...
Abstract Rheumatoid arthritis (RA) is a chronic disease with complex molecular network of pathophysiology, single drug usually not full satisfactory because it almost impossible to target the whole disease. Drug combinations that act synergistically each another an effective strategy in RA therapy. In this study, we aimed establish new search synergized compounds from Chinese herbal medicine (CHM) used RA. Based on multi-information integrative approaches, imperatorin (IMP) and β-sitosterol...